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INJECTION

CRITICAL MATERIAL CONSIDERATIONS FOR DRUG CONTAINMENT
PREFILLED SYRINGES
Richard Molin
CRITICAL MATERIAL CONSIDERATIONS FOR DRUG CONTAINMENT
Dick Molin highlights some of the hazards that arise through the use of traditional lubricious coatings in parenteral delivery devices. Particular focus is paid to the problems of protein aggregation and trace impurities leaching from elastomeric components before describing how the polymer Parylene, applied as a very thin coating using SCS’ unique deposition method, avoids them.
STEVEN R KAUFMAN, BESPAK
INTERVIEW
Steven Kaufman
Bespak
STEVEN R KAUFMAN, BESPAK
Steven Kaufman is Global Business Development Lead at Bespak Europe Ltd, responsible for business development activities related to injectable devices such as auto-injectors and wearable injection systems.
USING POLYMERIC PDC TECHNOLOGY TO IMPROVE AUTO-INJECTOR DESIGN
PREFILLED SYRINGES
Jonathan Lawson
SMC Ltd
USING POLYMERIC PDC TECHNOLOGY TO IMPROVE AUTO-INJECTOR DESIGN
The limitations of using glass-based auto-injectors, such as contamination, and the need for delivering complex, viscous preparations, have led to a new approach that uses polymeric PDC technology instead. Jonathan Lawson, Jonathan Bradshaw and Susie White look at what polymeric PDCs can offer in making auto-injectors truly patient-centric.
DESIGN VALIDATION TESTING – DRUG DELIVERY DEVICES
EXPERT VIEW
Mark Turner
DESIGN VALIDATION TESTING – DRUG DELIVERY DEVICES
From a regulatory perspective, Mark Turner provides a summary of the current requirements of parenteral device manufacturers in the area of design validation testing.
COMPLEX DEVICES, SIMPLE PATIENT CARE
PREFILLED SYRINGES
Adrien Tisserand
Nemera
COMPLEX DEVICES, SIMPLE PATIENT CARE
Adrien Tisserand explains how the recent granting of German Pharmaceutical Drug Manufacturing Authorisation for Nemera’s facility in Neuenburg enhances the company’s offering to industry, before going on to discuss the Safelia® auto-injector and Safe’n’Sound® safety device platforms.
WEARABLE INJECTOR PLATFORM: THE CASE FOR EARLY PARTNERING
WEARABLES
Dr Jeannie Joughin
Enable Injections
WEARABLE INJECTOR PLATFORM: THE CASE FOR EARLY PARTNERING
Jeannie Joughin describes how significant factors and developments have converged leading to the rise of patient-centric healthcare and self-administration, the wearable injector at the cutting edge. Also showing that early clinical partnership with a platform wearable device company is beneficial across numerous criteria, and how this was a key design consideration for Enable’s wearable technology.
PUTTING PATIENTS FIRST: INNOVATING DRUG CONTAINMENT AND DELIVERY
WEARABLES
Chris Henshall
West Pharmaceutical Services
PUTTING PATIENTS FIRST: INNOVATING DRUG CONTAINMENT AND DELIVERY
Innovations in self-administered drug delivery systems are transitioning care out of hospitals and clinical settings into the home. To ensure patient compliance with treatment is maintained, an easy-to-use self-administration system can be key. Chris Henshall discusses the factors manufacturers should consider to ensure self-injected therapies meet patients’ needs and therefore improve patient outcomes.
HOW LUBRICANT CHOICE AFFECTS DOSE ACCURACY IN INSULIN PUMPS
WEARABLES
Dr Jackson Thornton
HOW LUBRICANT CHOICE AFFECTS DOSE ACCURACY IN INSULIN PUMPS
The development of fully automated, closed-loop glucose monitoring and insulin delivery systems can closely mimic a real pancreas. However, since the patient is not directly involved in administering the dose, these devices depend on one key factor - dosing accuracy. Jackson Thornton and Vinay Sakhrani examine how lubricant selection in the insulin cartridge, typically an afterthought, can make the delivery device more accurate.
DEVICE TRAINING AND ONBOARDING CONSIDERATIONS FOR ON-BODY DELIVERY SYSTEMS
WEARABLES
Joe Reynolds
Noble
DEVICE TRAINING AND ONBOARDING CONSIDERATIONS FOR ON-BODY DELIVERY SYSTEMS
New delivery systems for larger volume and more complex drugs, such as wearable injectors, are revolutionising patient treatment. However, research has shown that patients need to receive quality training and onboarding to ensure they use the devices properly and retain the information. Joe Reynolds explores the factors that need to be considered in developing optimal training devices for patients.
REDUCING THE COMPLEXITY OF LARGE-VOLUME SELF-INJECTION FOR PHARMA COMPANIES & PATIENTS
WEARABLES
Ian Thompson
Ypsomed
REDUCING THE COMPLEXITY OF LARGE-VOLUME SELF-INJECTION FOR PHARMA COMPANIES & PATIENTS
Ian Thompson updates us on YpsoDose, a new prefilled, large-volume patch injector platform, and how it is designed to simplify the approach to wearable injectors for both pharma companies and patients.
FROM VIAL TO WEARABLE INJECTOR
WEARABLES
Dr Kate Hudson-Farmer
FROM VIAL TO WEARABLE INJECTOR
While autoinjectors are often the delivery method of choice for patient self-administration, there are occasions when a vial and syringe format is required. To overcome the problems associated with this method, Medicom has developed a flexible, wearable patch pump which can accept a simple glass vial and provide a fully automated injection system. Hans Jensen and Kate Hudson-Farmer explain how it works.
GETTING TO KNOW SENSILE MEDICAL
INTERVIEW
Derek Brandt
GETTING TO KNOW SENSILE MEDICAL
Chief Executive Officer Derek Brandt and three of his colleagues – Christoph Lüdi, Head of Systems Engineering, Alex Perrier, Senior Technology Manager, and Marco Drüssel, Mechanical Engineering Manager – have all been a part of Sensile Medical for the past ten years, and here reflect on the company’s past and discuss the future.
BEYOND CONNECTIVITY: ENABLE & FLEX ANNOUNCE THE ENABLE SMART DEVICE
CONNECTIVITY
Matthew Huddleston
Enable Injections
BEYOND CONNECTIVITY: ENABLE & FLEX ANNOUNCE THE ENABLE SMART DEVICE
Matthew J Huddleston and Angela Wright talk about integrating Bluetooth connectivity into Enable’s latest Smart On-Body Delivery Device, describing how the Flex/Enable partnership has also been expanded to encompass Flex’s Digital Health Platform.
ADDRESSING EVOLVING HEALTHCARE NEEDS WITH DIGITAL HEALTH: CONNECTING DRUG DELIVERY
CONNECTIVITY
Dr Sundeep Kankanala
BD (Becton Dickinson & Company)
ADDRESSING EVOLVING HEALTHCARE NEEDS WITH DIGITAL HEALTH: CONNECTING DRUG DELIVERY
Sundeep Kankanala, Dave Icke and Chris Franzese explain how BD is moving towards providing solutions rather than products, particularly in the field of diabetes, discussing two frameworks created to improve the impact of the connected solutions.
SAFEGUARDING USER NEEDS: THE LONG-TERM LEGACY OF SHL’S PATIENT-CENTRIC DESIGNS
INJECTION
Jochen Ratjen
SHL Medical
SAFEGUARDING USER NEEDS: THE LONG-TERM LEGACY OF SHL’S PATIENT-CENTRIC DESIGNS
Jochen Ratjen talks about his personal experiences, what patient-centricity means to SHL, and how SHL’s designs are moving ahead with the changing trends.
FAST-TO-MARKET LARGE VOLUME INJECTOR FOR SELF-ADMINISTRATION
INJECTION
Bjørn Knud Andersen
FAST-TO-MARKET LARGE VOLUME INJECTOR FOR SELF-ADMINISTRATION
In response to a set of very specific device objectives Bjørn Knud Andersen and Bjarne Sørensen present an electronic, connected large-volume injector concept for self-administration as the ideal solution.
CONTINUOUS GROWTH & INNOVATION IN COMBINATION PRODUCT MARKET PRESENTS CHALLENGES & OPPORTUNITIES
PREFILLED SYRINGES
Paul Sullivan
Noble
CONTINUOUS GROWTH & INNOVATION IN COMBINATION PRODUCT MARKET PRESENTS CHALLENGES & OPPORTUNITIES
Paul Sullivan describes how smart, error-detecting training devices that are true to the form and function of the actual device deliver the most promising impact on adherence and compliance for patient self-injection.
NEEDLE-FREE JET INJECTION IN WORKPLACE INFLUENZA CLINICS
EXPERT VIEW
Tara Miller
NEEDLE-FREE JET INJECTION IN WORKPLACE INFLUENZA CLINICS
Tara Miller, Chris Galloway, and William E Gannon Jr evaluate an unmet need for increasing immunisation coverage in workplace influenza clinics by offering needle-free injection technology.
READY-TO-USE COMPONENTS
INJECTION
Joël Cotten
Aptar Pharma
READY-TO-USE COMPONENTS
Joël Cotten discusses the importance of sterile transfer in parenteral combination product manufacturing and Aptar Pharma’s gamma sterilisation suitable ready-to-use delivery device components.
INJECTABLE DRUG DELIVERY: DEVICES MEET NEXT-GENERATION FORMULATIONS
EXPERT VIEW
Dr Iulia Karlsson
INJECTABLE DRUG DELIVERY: DEVICES MEET NEXT-GENERATION FORMULATIONS
Iulia Karlsson, discusses a new technology called BeloGal which allows drugs to be delivered in high doses to the right organ and avoids the problems of low water solubility that hamper many modern formulations.
YPSODOSE WEARABLE DEVICE FOR THE LARGE-VOLUME INJECTION OF BIOLOGICS
WEARABLES
Ian Thompson
Ypsomed
YPSODOSE WEARABLE DEVICE FOR THE LARGE-VOLUME INJECTION OF BIOLOGICS
Ian Thompson describes self-injection device trends for larger injection volumes and introduces YpsoDose, a new prefilled large-volume wearable injector being developed by Ypsomed Delivery Systems.
ADJUSTING & CONTROLLING INJECTION SPEED BY DESIGN: IMPACT ON PAIN PERCEPTION
PREFILLED SYRINGES
Isabelle Delcroix
Nemera
ADJUSTING & CONTROLLING INJECTION SPEED BY DESIGN: IMPACT ON PAIN PERCEPTION
Isabell Delcroix and Pascal Dugand describe a study of the multi-award-winning Safelia® auto-injector platform, which showed how varying and slowing injection speed could reduce pain perception.
TONY BRATT, NORDIC PHARMA
INTERVIEW
Tony Bratt
TONY BRATT, NORDIC PHARMA
Tony Bratt discusses Nordic Pharma’s specialised market focused business model and how he believes drug delivery systems, in particular the platform device concept, can play an important role in this niche product field.
AUTO-INJECTOR DESIGN: MANAGING DRUG TEMPERATURE VARIATIONS
EXPERT VIEW
Jake Cowperthwaite
AUTO-INJECTOR DESIGN: MANAGING DRUG TEMPERATURE VARIATIONS
Jake Cowperthwaite examines the impact of environmental and drug temperature variation on auto-injector performance and describes techniques for managing this variation on modern auto-injectors.
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