2023_Jun_Particle_Works_leaderboard

NASAL

NASAL DRUG DELIVERY: OVERCOMING CHALLENGES WITH A ROBUST PLATFORM STRATEGY

Richard Johnson explores the changing nasal delivery landscape, highlighting challenges in nasal drug formulation and potential methods to overcome them.

UNLOCKING THE POTENTIAL OF INTRANASAL DRUG DELIVERY

Allan Houston, Marcel Sachs and Heiko Rolland discuss the healthcare potential of intranasal drug delivery systems and the necessary steps for bringing these solutions to market.

SPRAY DELIVERY: TARGETING PATIENT NEEDS AND EXPECTATIONS WITH PRECISION

Gladys Corrons-Bouis

SPRAY DELIVERY: TARGETING PATIENT NEEDS AND EXPECTATIONS WITH PRECISION

Gladys Corrons-Bouis and Cyril Le Loc’h discuss the use of spray delivery for precise targeting of patient medication.

CHALLENGES BESIDES DRUG TARGETING – REGULATORY HURDLES FOR MULTIDOSE NASAL SPRAYS

Dr Marie-Christine Klein

CHALLENGES BESIDES DRUG TARGETING – REGULATORY HURDLES FOR MULTIDOSE NASAL SPRAYS

Marie-Christine Klein, Andreas Bilstein and Rouven Kraus, discuss recent regulatory changes affecting drug-device combination products, using the example of a multidose nasal spray.

BENEFITS OF INNOVATIVE COMPRESSED GAS-POWERED INTRANASAL DRUG DELIVERY DEVICES

BENEFITS OF INNOVATIVE COMPRESSED GAS-POWERED INTRANASAL DRUG DELIVERY DEVICES

Albie Lavin discusses the exciting potential of propellant-driven systems for intranasal delivery, and how Picocyl’s Pico-Cylinders provide the ideal mechanism to take advantage of this potential.

TAKING A DRUG TO FIRST-IN-HUMAN TRIALS IN A BESPOKE DEVICE FOR TARGETED INTRANASAL DELIVERY

TAKING A DRUG TO FIRST-IN-HUMAN TRIALS IN A BESPOKE DEVICE FOR TARGETED INTRANASAL DELIVERY

Mark Allen, Andrew Fiorini and Shai Assia discuss the need to develop delivery devices early when formulating nasally delivered drugs for systemic and local action, and a method by which the route to clinic can be made easier, faster and cheaper.

SPRAYTEC LASER DIFFRACTION: ROBUST, REPRODUCIBLE DROPLET SIZE DATA

Malvern Panalytical

SPRAYTEC LASER DIFFRACTION: ROBUST, REPRODUCIBLE DROPLET SIZE DATA

Anne Virden discusses the benefits and applications of Malvern Panalytical's Spraytec laser diffraction system for the measurement of spray particles and droplets.

INTERVIEW: RDD EUROPE 2023 REVIEW & RDD 2024 PREVIEW

CONFERENCE SHOWCASE

INTERVIEW: RDD EUROPE 2023 REVIEW & RDD 2024 PREVIEW

Respiratory Drug Delivery talks with ONdrugDelivery, reviewing highlights of the successful RDD Europe 2023 event, which took place in Antibes, France last May, then describing what’s ahead for RDD 2024, which will take place in Tuscon, AZ, US, next May, including some of the key upcoming deadlines for participants.

CUSTOMISABLE MESH NEBULISER PLATFORMS: VALUE IN COMBINATION PRODUCT DEVELOPMENT

Edgar Hernan Cuevas Brun

HCmed Innovations

CUSTOMISABLE MESH NEBULISER PLATFORMS: VALUE IN COMBINATION PRODUCT DEVELOPMENT

Edgar Hernan Cuevas Brun and Yuan-Ming Hsu look at the advantages of customisable nebuliser platforms for new combination products.

DEVELOPING AN INHALABLE FORMULATION OF THE FIRST GENERATIVE AI DRUG

Insilico Medicine

DEVELOPING AN INHALABLE FORMULATION OF THE FIRST GENERATIVE AI DRUG

Brita Belli introduces Insilico Medecine’s inhalable formulation of its AI-designed therapy for the treatment of idiopathic pulmonary fibrosis, its progression through clinical trials and the company’s approach to generative AI in the pharmaceutical space more broadly.

ACCELERATING THE GO-TO-MARKET OF NASAL COMBINATION PRODUCTS WITH INTEGRATED SOLUTIONS

Séverine Duband

ACCELERATING THE GO-TO-MARKET OF NASAL COMBINATION PRODUCTS WITH INTEGRATED SOLUTIONS

Séverine Duband and Audrey Chandra discuss emerging trends in the ear, nose and throat market and how Nemera can assist in bringing new devices to market.

NAVIGATING THE CHALLENGES OF BRINGING INTRANASAL DRUG FORMULATIONS & DEVICES TO PATIENTS

NAVIGATING THE CHALLENGES OF BRINGING INTRANASAL DRUG FORMULATIONS & DEVICES TO PATIENTS

Joe Neale and Ross Errington explore the obstacles and opportunities facing the intranasal drug delivery market and how manufacturers can overcome them by harnessing innovative platforms like Unidose^® Xtra.

THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES

Dr Marie-Christine Klein

THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES

Marie-Christine Klein, Andreas Bilstein and Caroline Hoffmann discuss the underlying techniques involved in the use of metered pump-based soft mist devices and their application diversity.

THE POTENTIAL AND THE CHALLENGES OF NASAL VACCINATION

THE POTENTIAL AND THE CHALLENGES OF NASAL VACCINATION

Julie Suman and Nektaria Karavas discuss the challenges and opportunities of intranasal vaccination – showcasing current understanding for both liquid and powder products. Experimental studies highlight critical issues, the performance of commercially available devices and developments in formulation practice.

STEPS TO SUCCESS IN NOSE-TO-BRAIN DRUG DELIVERY

STEPS TO SUCCESS IN NOSE-TO-BRAIN DRUG DELIVERY

Reenal Gandhi and Gemma Budd consider the multiple hurdles associated with developing nasal drug delivery solutions, current understanding of the associated biology and the advantages of alternative device designs and state-of-the-art formulation practice.

THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION

THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION

James Silk discusses the importance of accounting for uncertainty when characterising the extractables profile of a medication, with particular reference to the ISO 10993 standard.

ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE

INDUSTRIALISATION

Drew Jelgerhuis

Scherdel Medtec North America

ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE

Drew Jelgerhuis looks at how a design-for-excellence (DFX) systematic approach can help manufacturers achieve their objectives.

TAKING THE STING OUT OF VACCINES

Dr Heather Jameson

TAKING THE STING OUT OF VACCINES

Heather Jameson, Juliette Ngan and Omar Shah discuss the potential advantages and challenges of intranasal and inhaled vaccines in the context of global respiratory pandemics.

SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS

SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS

Paul Kippax discusses the analytical techniques used for in vitro characterisation of nasal sprays, and how their use can accelerate and de-risk both innovator and generic nasal drug development.

NASAL DELIVERY – A GALAXY NOT SO FAR AWAY… A BRIEF MARKET HISTORY OF THE NASAL DELIVERY LANDSCAPE

NASAL DELIVERY – A GALAXY NOT SO FAR AWAY… A BRIEF MARKET HISTORY OF THE NASAL DELIVERY LANDSCAPE

Mark Ignaczak provides an insight into the history of nasal drug delivery and looks at the advantages of the nasal delivery route.

HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS

INDUSTRIALISATION

HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS

Mark Tunkel and Niyati Sapatnekar discuss Nemera’s holistic approach to development and industrialisation.

A GAME CHANGER FOR HIGH-RISK MEDICATIONS VIA AN INTRANASAL DELIVERY PLATFORM

A GAME CHANGER FOR HIGH-RISK MEDICATIONS VIA AN INTRANASAL DELIVERY PLATFORM

Marcel Botha, Andreas Bilstein, Houssam Elghobary and Rouven Kraus discuss the benefits of the Validose digital health platform for the safe delivery of high-value and/or high-risk products.

ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY

ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY

William Welch considers the evolution of compressed gas alternatives to spring power for single-use drug delivery devices.

NANOTECHNOLOGY: A NEXT-GENERATION TOOL FOR PULMONARY & NASAL DELIVERY

Frédérique Bordes-Picard

NANOTECHNOLOGY: A NEXT-GENERATION TOOL FOR PULMONARY & NASAL DELIVERY

Frédérique Bordes-Picard looks at the role of nanotechnology in the nasal and pulmonary routes of drug delivery and explains how nanoparticle explains how nanoparticle solutions could transform patient comfort and compliance.

WAITING WITH BATED BREATH – WHAT’S IN STORE FOR 2022

WAITING WITH BATED BREATH – WHAT’S IN STORE FOR 2022

Rob Udale and Heather Jameson discuss the exciting developments taking place in the design of inhalation devices and share their predictions for the top five inhalation trends to watch as 2022 unfolds, and beyond.

NOSE-TO-BRAIN DRUG ADMINISTRATION AND A NOVEL APPROACH WITH AN OLD FAMILIAR

Dr Marie-Christine Klein

NOSE-TO-BRAIN DRUG ADMINISTRATION AND A NOVEL APPROACH WITH AN OLD FAMILIAR

Marie-Christine Klein, Andreas Bilstein and Rouven Kraus look at the advantages of the nose-to-brain route and soft mist nasal sprays for drug administration.

INTERVIEW: JON LENN & JON VOLMER, MEDPHARM

INTERVIEW: JON LENN & JON VOLMER, MEDPHARM

Jon Lenn and Jon Volmer talked with Guy Furness about the importance of nasal modelling, focusing on MedPharm’s own nasal cavity modelling technology, MedCast, its unique characteristics and benefits and the value it brings to the company’s offering for nasally delivered products.

AN INVITATION TO PARTICIPATE IN STANDARDISATION OF PARTICLE MEASUREMENTS FOR PHARMACEUTICALS

Dr Caterina Minelli

AN INVITATION TO PARTICIPATE IN STANDARDISATION OF PARTICLE MEASUREMENTS FOR PHARMACEUTICALS

Caterina Minelli discusses the importance of co-operation between metrology institutes and the pharmaceutical industry in the pursuit of improving analytical techniques and standards for the characterisation of particle attributes in drug development.

NASAL DELIVERY SYSTEM EXPANDS PUBLIC AND PATIENT ACCESS TO NALOXONE TO MITIGATE THE OPIOID OVERDOSE EPIDEMIC

NASAL DELIVERY SYSTEM EXPANDS PUBLIC AND PATIENT ACCESS TO NALOXONE TO MITIGATE THE OPIOID OVERDOSE EPIDEMIC

Todd D Pizitz and Donald R Mealing discuss the ongoing US opioid epidemic, the CounterAct cap containing a single dose of naloxone to be attached to prescribed opioids, and a recent pilot market study done to gauge public enthusiasm for this life-saving technology.

ADDRESSING SYSTEMIC DELIVERY WITH A UNIT-DOSE NASAL SPRAY

ADDRESSING SYSTEMIC DELIVERY WITH A UNIT-DOSE NASAL SPRAY

Audrey Chandra and Raphaële Audibert discuss the benefits of a unit-dose nasal spray for rapid treatment in an emergency.

BREACHING THE BLOOD-BRAIN-BARRIER WITH PARTICLE-BASED NASAL DELIVERY SYSTEMS

BREACHING THE BLOOD-BRAIN-BARRIER WITH PARTICLE-BASED NASAL DELIVERY SYSTEMS

Tom French talks about the advantages of the nasal drug delivery route and crossing the blood-brain-barrier to treat central nervous system diseases.

ADDRESSING THE CHALLENGES OF NASAL BIOTHERAPEUTIC DRUG DELIVERY

ADDRESSING THE CHALLENGES OF NASAL BIOTHERAPEUTIC DRUG DELIVERY

Robert Lee discusses the benefits of administering drugs to the nasal cavity, as well as the main challenges in formulation for this route and the strategies that can be applied to overcome them.

IMPROVING IN VITRO TEST METHODS FOR NASAL DRUG PRODUCTS

Copley Scientific

IMPROVING IN VITRO TEST METHODS FOR NASAL DRUG PRODUCTS

Mark Copley and Anna Sipitanou look at how in vitro testing is being refined for greater repeatability to maximise its value as a low-cost tool for product development, including an assessment of the role of automation in improving the sensitivity of in vitro testing.

DELIVERING ON THE PROMISES OF INTRANASAL VACCINATION

DELIVERING ON THE PROMISES OF INTRANASAL VACCINATION

Julie Suman and Nektaria Karavas review intranasal delivery as a method of vaccine administration and consider the challenges and benefits of intranasal delivery.

SUCCESSFULLY BALANCING THE NEEDS OF THE PLANET WITH THE NEEDS OF THE PATIENT

SUCCESSFULLY BALANCING THE NEEDS OF THE PLANET WITH THE NEEDS OF THE PATIENT

Christophe Marie, Taylor Price and Julien Storz chart the commitments and progress made to date by Aptar in achieving its sustainability targets. The authors also provide examples of integrated, circular economy initiatives undertaken by Aptar Pharma at a product solution level and comment on concrete commitments that can be made to further progress towards sustainability.

THE CRITICAL ROLE OF TRAINING IN THE USE OF NASAL RESCUE THERAPIES

THE CRITICAL ROLE OF TRAINING IN THE USE OF NASAL RESCUE THERAPIES

Tim McLeroy discusses the role of nasally administered rescue treatments in preventing deaths from opioid overdose or misuse – highlighting the importance of training and treatment availability.

SPRAY CHARACTERISATION TESTING FOR ORALLY INHALED AND NASAL DRUG PRODUCTS

Francois Billard

SPRAY CHARACTERISATION TESTING FOR ORALLY INHALED AND NASAL DRUG PRODUCTS

Francois Billard and Lei Mao look at measurement systems for spray pattern and plume geometry dispensed by orally inhaled and nasal drug products.

BIOCOMPATIBILITY OF MEDICINAL PRODUCT MEDICAL DEVICE COMBINATIONS FOR AIRWAY DELIVERY

BIOCOMPATIBILITY OF MEDICINAL PRODUCT MEDICAL DEVICE COMBINATIONS FOR AIRWAY DELIVERY

Mark Turner discusses biocompatibility testing for inhaled medical products, with particular reference to ISO 18562, and what Medical Engineering Technologies has learned from three years of breathing component biocompatibility testing.

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