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NASAL

NASAL
NAVIGATING THE CHALLENGES OF BRINGING INTRANASAL DRUG FORMULATIONS & DEVICES TO PATIENTS
Joe Neale and Ross Errington explore the obstacles and opportunities facing the intranasal drug delivery market and how manufacturers can overcome them by harnessing innovative platforms like Unidose® Xtra.
NASAL
THE POTENTIAL AND THE CHALLENGES OF NASAL VACCINATION
Julie Suman and Nektaria Karavas discuss the challenges and opportunities of intranasal vaccination – showcasing current understanding for both liquid and powder products. Experimental studies highlight critical issues, the performance of commercially available devices and developments in formulation practice.
ACCELERATING THE GO-TO-MARKET OF NASAL COMBINATION PRODUCTS WITH INTEGRATED SOLUTIONS
NASAL
Séverine Duband
Nemera
ACCELERATING THE GO-TO-MARKET OF NASAL COMBINATION PRODUCTS WITH INTEGRATED SOLUTIONS
Séverine Duband and Audrey Chandra discuss emerging trends in the ear, nose and throat market and how Nemera can assist in bringing new devices to market.
THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES
PULMONARY
Dr Marie-Christine Klein
URSATEC
THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES
Marie-Christine Klein, Andreas Bilstein and Caroline Hoffmann discuss the underlying techniques involved in the use of metered pump-based soft mist devices and their application diversity.
STEPS TO SUCCESS IN NOSE-TO-BRAIN DRUG DELIVERY
NASAL
Reenal Gandhi
Aptar Pharma
STEPS TO SUCCESS IN NOSE-TO-BRAIN DRUG DELIVERY
Reenal Gandhi and Gemma Budd consider the multiple hurdles associated with developing nasal drug delivery solutions, current understanding of the associated biology and the advantages of alternative device designs and state-of-the-art formulation practice.
THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION
EXPERT VIEW
James Silk
THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION
James Silk discusses the importance of accounting for uncertainty when characterising the extractables profile of a medication, with particular reference to the ISO 10993 standard.
ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE
INDUSTRIALISATION
Drew Jelgerhuis
Scherdel Medtec North America
ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE
Drew Jelgerhuis looks at how a design-for-excellence (DFX) systematic approach can help manufacturers achieve their objectives.
TAKING THE STING OUT OF VACCINES
EXPERT VIEW
Dr Heather Jameson
TAKING THE STING OUT OF VACCINES
Heather Jameson, Juliette Ngan and Omar Shah discuss the potential advantages and challenges of intranasal and inhaled vaccines in the context of global respiratory pandemics.
SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS
EXPERT VIEW
Dr Paul Kippax
SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS
Paul Kippax discusses the analytical techniques used for in vitro characterisation of nasal sprays, and how their use can accelerate and de-risk both innovator and generic nasal drug development.
NASAL DELIVERY – A GALAXY NOT SO FAR AWAY… A BRIEF MARKET HISTORY OF THE NASAL DELIVERY LANDSCAPE
EXPERT VIEW
Mark Ignaczak
NASAL DELIVERY – A GALAXY NOT SO FAR AWAY… A BRIEF MARKET HISTORY OF THE NASAL DELIVERY LANDSCAPE
Mark Ignaczak provides an insight into the history of nasal drug delivery and looks at the advantages of the nasal delivery route.
HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS
INDUSTRIALISATION
Mark Tunkel
Nemera
HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS
Mark Tunkel and Niyati Sapatnekar discuss Nemera’s holistic approach to development and industrialisation.
A GAME CHANGER FOR HIGH-RISK MEDICATIONS VIA AN INTRANASAL DELIVERY PLATFORM
CONNECTIVITY
Marcel Botha
Aero Pump
A GAME CHANGER FOR HIGH-RISK MEDICATIONS VIA AN INTRANASAL DELIVERY PLATFORM
Marcel Botha, Andreas Bilstein, Houssam Elghobary and Rouven Kraus discuss the benefits of the Validose digital health platform for the safe delivery of high-value and/or high-risk products.
ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY
INJECTION
Bill Welch
Picocyl
ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY
William Welch considers the evolution of compressed gas alternatives to spring power for single-use drug delivery devices.
NANOTECHNOLOGY: A NEXT-GENERATION TOOL FOR PULMONARY & NASAL DELIVERY
EXPERT VIEW
Frédérique Bordes-Picard
NANOTECHNOLOGY: A NEXT-GENERATION TOOL FOR PULMONARY & NASAL DELIVERY
Frédérique Bordes-Picard looks at the role of nanotechnology in the nasal and pulmonary routes of drug delivery and explains how nanoparticle explains how nanoparticle solutions could transform patient comfort and compliance.
WAITING WITH BATED BREATH – WHAT’S IN STORE FOR 2022
EXPERT VIEW
Rob Udale
WAITING WITH BATED BREATH – WHAT’S IN STORE FOR 2022
Rob Udale and Heather Jameson discuss the exciting developments taking place in the design of inhalation devices and share their predictions for the top five inhalation trends to watch as 2022 unfolds, and beyond.
NOSE-TO-BRAIN DRUG ADMINISTRATION AND A NOVEL APPROACH WITH AN OLD FAMILIAR
NASAL
Dr Marie-Christine Klein
Aero Pump
NOSE-TO-BRAIN DRUG ADMINISTRATION AND A NOVEL APPROACH WITH AN OLD FAMILIAR
Marie-Christine Klein, Andreas Bilstein and Rouven Kraus look at the advantages of the nose-to-brain route and soft mist nasal sprays for drug administration.
INTERVIEW: JON LENN & JON VOLMER, MEDPHARM
INTERVIEW
Dr Jon Lenn
MedPharm
INTERVIEW: JON LENN & JON VOLMER, MEDPHARM
Jon Lenn and Jon Volmer talked with Guy Furness about the importance of nasal modelling, focusing on MedPharm’s own nasal cavity modelling technology, MedCast, its unique characteristics and benefits and the value it brings to the company’s offering for nasally delivered products.
AN INVITATION TO PARTICIPATE IN STANDARDISATION OF PARTICLE MEASUREMENTS FOR PHARMACEUTICALS
EXPERT VIEW
Dr Caterina Minelli
AN INVITATION TO PARTICIPATE IN STANDARDISATION OF PARTICLE MEASUREMENTS FOR PHARMACEUTICALS
Caterina Minelli discusses the importance of co-operation between metrology institutes and the pharmaceutical industry in the pursuit of improving analytical techniques and standards for the characterisation of particle attributes in drug development.
NASAL DELIVERY SYSTEM EXPANDS PUBLIC AND PATIENT ACCESS TO NALOXONE TO MITIGATE THE OPIOID OVERDOSE EPIDEMIC
NASAL
Dr Todd Pizitz
CounterAct
NASAL DELIVERY SYSTEM EXPANDS PUBLIC AND PATIENT ACCESS TO NALOXONE TO MITIGATE THE OPIOID OVERDOSE EPIDEMIC
Todd D Pizitz and Donald R Mealing discuss the ongoing US opioid epidemic, the CounterAct cap containing a single dose of naloxone to be attached to prescribed opioids, and a recent pilot market study done to gauge public enthusiasm for this life-saving technology.
ADDRESSING SYSTEMIC DELIVERY WITH A UNIT-DOSE NASAL SPRAY
NASAL
Audrey Chandra
Nemera
ADDRESSING SYSTEMIC DELIVERY WITH A UNIT-DOSE NASAL SPRAY
Audrey Chandra and Raphaële Audibert discuss the benefits of a unit-dose nasal spray for rapid treatment in an emergency.
BREACHING THE BLOOD-BRAIN-BARRIER WITH PARTICLE-BASED NASAL DELIVERY SYSTEMS
NASAL
Tom French
3P Innovation
BREACHING THE BLOOD-BRAIN-BARRIER WITH PARTICLE-BASED NASAL DELIVERY SYSTEMS
Tom French talks about the advantages of the nasal drug delivery route and crossing the blood-brain-barrier to treat central nervous system diseases.
ADDRESSING THE CHALLENGES OF NASAL BIOTHERAPEUTIC DRUG DELIVERY
EXPERT VIEW
Robert Lee
ADDRESSING THE CHALLENGES OF NASAL BIOTHERAPEUTIC DRUG DELIVERY
Robert Lee discusses the benefits of administering drugs to the nasal cavity, as well as the main challenges in formulation for this route and the strategies that can be applied to overcome them.
IMPROVING IN VITRO TEST METHODS FOR NASAL DRUG PRODUCTS
NASAL
Mark Copley
Copley Scientific
IMPROVING IN VITRO TEST METHODS FOR NASAL DRUG PRODUCTS
Mark Copley and Anna Sipitanou look at how in vitro testing is being refined for greater repeatability to maximise its value as a low-cost tool for product development, including an assessment of the role of automation in improving the sensitivity of in vitro testing.
DELIVERING ON THE PROMISES OF INTRANASAL VACCINATION
NASAL
Dr Julie Suman
Aptar Pharma
DELIVERING ON THE PROMISES OF INTRANASAL VACCINATION
Julie Suman and Nektaria Karavas review intranasal delivery as a method of vaccine administration and consider the challenges and benefits of intranasal delivery.
SUCCESSFULLY BALANCING THE NEEDS OF THE PLANET WITH THE NEEDS OF THE PATIENT
SUSTAINABILITY
Julien Storz
Aptar Pharma
SUCCESSFULLY BALANCING THE NEEDS OF THE PLANET WITH THE NEEDS OF THE PATIENT
Christophe Marie, Taylor Price and Julien Storz chart the commitments and progress made to date by Aptar in achieving its sustainability targets. The authors also provide examples of integrated, circular economy initiatives undertaken by Aptar Pharma at a product solution level and comment on concrete commitments that can be made to further progress towards sustainability.
THE CRITICAL ROLE OF TRAINING IN THE USE OF NASAL RESCUE THERAPIES
NASAL
Tim McLeroy
Noble
THE CRITICAL ROLE OF TRAINING IN THE USE OF NASAL RESCUE THERAPIES
Tim McLeroy discusses the role of nasally administered rescue treatments in preventing deaths from opioid overdose or misuse – highlighting the importance of training  and treatment availability.
SPRAY CHARACTERISATION TESTING FOR ORALLY INHALED AND NASAL DRUG PRODUCTS
RESPIRATORY
Francois Billard
Recipharm
SPRAY CHARACTERISATION TESTING FOR ORALLY INHALED AND NASAL DRUG PRODUCTS
Francois Billard and Lei Mao look at measurement systems for spray pattern and plume geometry dispensed by orally inhaled and nasal drug products.
BIOCOMPATIBILITY OF MEDICINAL PRODUCT MEDICAL DEVICE COMBINATIONS FOR AIRWAY DELIVERY
EXPERT VIEW
Mark Turner
BIOCOMPATIBILITY OF MEDICINAL PRODUCT MEDICAL DEVICE COMBINATIONS FOR AIRWAY DELIVERY
Mark Turner discusses biocompatibility testing for inhaled medical products, with particular reference to ISO 18562, and what Medical Engineering Technologies has learned from three years of breathing component biocompatibility testing.
HOW EVOLVING PATIENT NEEDS HAVE FUELLED THE DEVELOPMENT OF NASAL DRUG DELIVERY
NASAL
Dr Julie Suman
Next Breath
HOW EVOLVING PATIENT NEEDS HAVE FUELLED THE DEVELOPMENT OF NASAL DRUG DELIVERY
Julie Suman considers how the needs of the patient have driven advances in nasal drug delivery and looks at the latest developments and benefits of this method of drug delivery.
INTEGRATED TURNKEY SOLUTIONS: KEY TO SUCCESSFUL NASAL COMBINATION PRODUCT DEVELOPMENT
RESPIRATORY
Alain Regard
Nemera
INTEGRATED TURNKEY SOLUTIONS: KEY TO SUCCESSFUL NASAL COMBINATION PRODUCT DEVELOPMENT
Alain Regard, Audrey Chandra and Pascale Farjas discuss the use of the nasal route for locally and systemic-acting drug treatments.
NASAL DELIVERY: AN OPPORTUNITY FOR SIGNIFICANT IMPROVEMENTS IN PATIENT CARE
EXPERT VIEW
Dr Stuart Madden
NASAL DELIVERY: AN OPPORTUNITY FOR SIGNIFICANT IMPROVEMENTS IN PATIENT CARE
Stuart Madden discusses the advantages of the nasal route of administration for the systemic delivery of therapeutics.
FORMULATION OPTIONS IN NASAL DRUG DELIVERY
EXPERT VIEW
Dr Richard Johnson
FORMULATION OPTIONS IN NASAL DRUG DELIVERY
Richard Johnson discusses the advantages of nasal delivery and why there is growing interest in this route of administration, as well as considering some of the challenges that may arise during the development of nasal formulations for use in the clinic, and the regulatory and testing requirements associated with them.
ASSESSING THE NASAL DRUG DELIVERY LANDSCAPE
NASAL
Dr Jon Volmer
MedPharm
ASSESSING THE NASAL DRUG DELIVERY LANDSCAPE
Jon Volmer, Jon Lenn and Professor Marc Brown discuss the role of reconstituted nasal epithelium in intranasal drug delivery.
SPRAY CHARACTERISATION TESTING
NASAL
Ann Flodin
Recipharm
SPRAY CHARACTERISATION TESTING
Ann Flodin introduces the company’s SprayVIEW® measurement and automated actuation stations for the development and quality control of container closures and finished products.
TOP FIVE DRUG DELIVERY TRENDS FOR 2021
EXPERT VIEW
Tom Oakley
TOP FIVE DRUG DELIVERY TRENDS FOR 2021
Tom Oakley provides an overview of the top five trends to expect in drug delivery in 2021.
INTRANASAL DELIVERY OF BIOLOGIC THERAPEUTICS AND VACCINES
NASAL
David Ward
Intertek Pharmaceutical Services
INTRANASAL DELIVERY OF BIOLOGIC THERAPEUTICS AND VACCINES
David Ward looks at how the nasal route of drug administration offers the potential to improve the delivery of biologics, even for very complex molecules such as antibodies – and why strategic formulation is required to make this a reality.
INTERVIEW WITH AARON MANN, CHIEF EXECUTIVE OFFICER, KINDEVA
INTERVIEW
Aaron Mann
INTERVIEW WITH AARON MANN, CHIEF EXECUTIVE OFFICER, KINDEVA
In this exclusive interview with ONdrugDelivery, Aaron Mann discusses how Kindeva is positioned to move forward as a major CDMO specialising in inhalation and transdermal dosage forms, having been formed from 3M’s drug delivery in May 2020. We also cover the impact of Covid-19, environmental sustainability, and current challenges faced by the pharmaceutical industry.
POLYMERIC EMI SHIELDING: PROVIDING A MORE SECURE FUTURE FOR PATIENTS
CONNECTIVITY
Marnik Vaes
SABIC
POLYMERIC EMI SHIELDING: PROVIDING A MORE SECURE FUTURE FOR PATIENTS
Marnik Vaes, Leen-Pieter Deurloo and Martin Sas discuss the role of polymeric electromagnetic interference shielding in providing a more secure future for patients in a connected world.
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