WEARABLES

WEARABLES

A NEW FRONTIER: SELF-ADMINISTRATION OF LYOPHILISED, LARGE-VOLUME SUBCUTANEOUS BIOLOGICS

Mehul Desai and Daniel Waites discuss the pros and cons of lyophilisation for biologic injectable drugs, and how Enable Injections’ enFuse device can provide an answer to the challenges of self-injection of large-volume and lyophilised biologics.

WEARABLES

CHRONIC PATIENTS AT THE CENTRE OF LARGE-VOLUME SC DELIVERY WITH A SUSTAINABLE ON-BODY INJECTOR

Cécile Gross and Mark Tunkel discuss the role of patient-centricity in the development of Nemera’s sustainable on-body injector platform.

EXPERT VIEW

Paramesh Natarajan

HOW LIFECYCLE ASSESSMENT SUPPORTS INSIGHT-DRIVEN SUSTAINABLE DESIGN

Paramesh Natarajan, Shadi Bavar and Charlie Dean present the case for using screening lifecycle assessments to lead into more detailed targeted and comprehensive lifecycle assessments focused on the areas of greatest environmental impact, using a screening lifecycle assessment of a hypothetical body-worn injector as an example.

EXPERT VIEW

Tom Oakley

“A CHILD IS NOT A SMALL ADULT”: CHALLENGES AND SOLUTIONS IN DEVELOPING DRUG DELIVERY DEVICES FOR CHILDREN

Tom Oakley and Heather Jameson consider the main differences in developing therapies and drug delivery devices for children and babies when compared with adults.

WEARABLES

Christian Esser Wiesemann

Ypsomed

YPSODOSE – THE CLINIC-READY 10 ML PATCH INJECTOR

Christian Esser Wiesemann provides the latest insights into the prefilled and pre-assembled YpsoDose patch injector, which is now available for clinical trials.

WEARABLES

Heiko Haller

ZwickRoell

PRODUCT SHOWCASE: COMPLETE SYSTEM FOR STANDARD-COMPLIANT TESTING OF WEARABLE INJECTORS

Specifically tailored to on-body delivery systems (OBDSs) / wearable injectors, ZwickRoell showcases its customised, comprehensive solution for performing functional tests in accordance with the ISO 11608-6 standard.

SUSTAINABILITY

Maike Wolf

Gerresheimer

SUSTAINABLE DESIGN OF A DRUG DELIVERY DEVICE FOR BIOPHARMACEUTICALS

Maike Wolf and Marie Stockton discuss how sustainability is a fundamental strategic priority for Gerresheimer. They also highlight how eco-design principles have been applied to the development of an on-body injector for subcutaneous delivery of biopharmaceuticals.

WEARABLES

Thomas Mayer

Sonceboz

COMPARISON OF MECHATRONIC VS MECHANICAL WEARABLE DRUG DELIVERY SYSTEMS

Thomas Mayer, Nicolas Bailo and Martin Liniger highlight some of the key challenges that mechanical and mechatronic drug delivery systems must overcome when delivering large volumes of biologics subcutaneously and explain the solutions that Sonceboz has considered during the development process of the company’s large-volume injector.

WEARABLES

Dr Iris Schnitzler

LTS

EXTENDING PATIENT-FRIENDLY DRUG DELIVERY TO HIGH-VOLUME WEARABLE DEVICES

Iris Schnitzler discusses the benefits of on-body delivery systems, including the flexibility and convenience they bring to patients managing chronic conditions, and how the Sorrel platform overcomes some of the inherent complexities and challenges of developing such a device. Dr Schnitzler then goes on to speak with Bas van Buijtenen and Andrei Yosef about the Sorrel platform and how its integration within LTS supports the company’s fundamental objectives of enabling partners and empowering patients.

WEARABLES

Dr Adam Stops

Stevanato Group

THE VERTIVA™ ON-BODY DELIVERY SYSTEM: EXPANDING OPPORTUNITIES IN HOME-BASED CARE

Adam Stops introduces Vertiva™, Stevanato Group’s next-generation on-body delivery system platform, and discusses how it meets the needs of pharma companies looking to deliver large-volume doses in a patient-centric manner.

CONNECTIVITY

Jimmy Fan

CC Bio

Technology Showcase: CCBio’s Felice Dose – Simplifying Subcutaneous Infusion

CCBio showcases Felice Dose, a revolutionary on-body injector (OBI) designed to address the challenges of traditional IV injections and SC drug administration.

EXPERT VIEW

Roger Bohannan

INJECTING INNOVATIVE SOLUTIONS INTO CONNECTED DELIVERY DEVICES

Roger Bohannan discusses the capabilities and design challenges of connected drug delivery devices.

EXPERT VIEW

Dave Beckstoffer

INCORPORATING MOTION DESIGN AT EARLY STAGES OF WEARABLE INJECTOR DEVELOPMENT

Dave Beckstoffer discusses the often overlooked importance of including motion system design considerations from the very earliest stages of wearable injector development, and how doing so can reduce costs, shorten timelines and improve patient outcomes.

EXPERT VIEW

Matt Parker

DIRECTIONS FOR WEARABLE ON-BODY INJECTOR SYSTEMS AND BEYOND

Matt Parker, Karthik Chellappan and David Cottenden discuss the current state of play for large-volume injection and look into the challenges that on-body delivery systems currently in development will need to overcome to find success in a changing marketplace.

EXPERT VIEW

Malcolm Boyd

WOULD YOU LIKE TO GO LARGE? KEY CONSIDERATIONS FOR LARGE-VOLUME INJECTORS

Malcolm Boyd discusses the factors that need to be considered early in the development of large-volume injectors, which will have a major influence on the performance, usability and cost of a device.

EXPERT VIEW

Thomas James

REUSABLE WEARABLE INJECTORS: LESSONS FROM IN VITRO DIAGNOSTICS

Thomas James explores how insights from the development of successful in vitro diagnostic instruments can help guide the evolution of wearable injectors.

WEARABLES

Beth McBride DiLauri

BD (Becton Dickinson & Company)

BD INNOVATION FOR SUBCUTANEOUS DELIVERY OF LARGE-VOLUME COMPLEX BIOLOGICS

Beth McBride DiLauri summarises the results of a clinical study on the BD Libertas™ Wearable Injector. The results position the device as a viable alternative to traditional intravenous administration.

INTERVIEW

Julien Martins

Paragon Medical

Interview with Julien Martins & David Philbrick

Julien Martins and David Philbrick talk exclusively with ONdrugDelivery's Guy Furness. They discuss a wide range of topics, including the services Paragon Medical provides the drug delivery industry, its wider business operations, the company’s expanded facilities in the US and Europe, and its new Advanced Surgical Innovation Center.

CONNECTIVITY

Fallyn Flaherty-Earp

Celanese

LESSONS FROM MARKETED MEDICAL DEVICES TO ENHANCE CONNECTED DRUG DELIVERY

Fallyn Flaherty-Earp looks at what medical device manufacturers can learn from connected devices already on the market and discusses the opportunities electronic inks can provide for the development of innovative therapies for the treatment of chronic diseases.

INJECTION

Dr Andreas Schneider

Ypsomed

HOW PATIENT & TREATMENT FACTORS SHAPE SUBCUTANEOUS DOSING PREFERENCES

Andreas Schneider highlights the importance of understanding the drivers of dosing preferences when it comes to choosing the right injection device for patients. Specifically, the research summarised here studies whether and how patient characteristics and treatment attributes influence the decision to use prefilled handheld autoinjectors or large-volume wearable injectors.

WEARABLES

Dr Andrei Yosef

Eitan Medical

ENABLING DRUG DEVELOPMENT THROUGH DRUG DELIVERY MANUFACTURING

Andrei Yosef looks at the role of manufacturing in the development of drug delivery devices and highlights the benefits of the company’s Sorrel device, which enables pharma companies to experiment during clinical trials to ensure that drugs produced are safe and cost-effective.

INDUSTRIALISATION

Peter Schmidt

ZwickRoell

PRODUCT SHOWCASE: New Requirements for Injection Devices Make Advanced Testing Solutions Necessary

ZwickRoell showcases its advanced testing solutions for injection devices including pens, autoinjectors and on-body delivery systems.

INTERVIEW

Guy Furness

Kymanox

Interview: Kymanox Executive Advisors Mathias Romacker, Fran DeGrazio & Paul Jansen

Mathias Romacker, Fran DeGrazio and Paul Jansen sit down with Guy Furness, to discuss what it is that has driven Kymanox’s rapid rise in the drug delivery space and what makes the consulting company’s model so successful, as well as to share their expertise on a variety of topics in an illuminating discussion, including connectivity, how large and small drug developers engage with consultancies, 5 mL autoinjectors and the interface between drug primary packaging and delivery devices.

WEARABLES

Jesper Roested

Subcuject

LOW-COMPLEXITY, EASY-TO-USE WEARABLE INJECTION PLATFORM

Jesper Roested discusses the increasing prevalence of biologics formulated for large-volume injections in drug development and how wearable devices, including Subcuject’s offering, may be a better solution for delivering these drugs than scaled-up conventional autoinjectors.

WEARABLES

Dr Mehul Desai

Enable Injections

REDUCE PHARMA DEVELOPMENT TIME: LARGE-VOLUME SUBCUTANEOUS DELIVERY WITH THE ENFUSE^®

Mehul Desai discusses how Enable Injections' enFuse^® delivery system provides a flexible alternative for subcutaneous administration of high-volume therapeutics.

PREFILLED SYRINGES

Dr Andrea Allmendinger

ten23 health

ANTICIPATING & MITIGATING CHALLENGES IN THE COMMERCIALISATION OF PREFILLED SYRINGES & INJECTION DEVICES – A TECHNICAL DRUG PRODUCT PERSPECTIVE

Andrea Allmendinger and Hanns-Christian Mahler both at ten23 health, provide an insight into the challenges of integrated development of drug product and device design and fill-finish manufacturing operations.

INJECTION

Victoria Morgan

West Pharmaceutical Services

BEING PREPARED FOR PHARMA INNOVATION IS KEY IN 2023

Victoria Morgan and Ana Marques Kuschel discuss three recent innovations that West Pharmaceutical Services has introduced to enable its partners to respond to specific market-driven challenges, from pandemic-driven pressures on fill-finish productivity to the underlying shift towards biologics and the accelerated growth of home-based treatment.

CONNECTIVITY

Mark Tunkel

Nemera

PATIENT JOURNEY AS THE FOUNDATION FOR HOLISTIC CONNECTED DEVICE DEVELOPMENT

Mark Tunkel and Cécile Gross consider the development of connected drug delivery devices and identify how understanding the patient journey from diagnosis to treatment can be used as an early-stage decision-making tool.

CONNECTIVITY

Dr Haykel Ben Jamaa

Sensirion

DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS

Haykel Ben Jamaa explores why modern society needs digital health and how it is organised and implemented, with a focus on sensing technologies empowering digital health technologies.

INDUSTRIALISATION

Drew Jelgerhuis

Scherdel Medtec North America

ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE

Drew Jelgerhuis looks at how a design-for-excellence (DFX) systematic approach can help manufacturers achieve their objectives.

INJECTION

Steve Augustyn

Cambridge Design Partnership

ISO 11608: WHAT THE NEW STANDARD MEANS FOR NIS MANUFACTURERS

Steve Augustyn looks at ISO 11608 and what it means for needle-based injection device manufacturers.

INJECTION

Jack Auld

Altaviz

DESIGN STRATEGY & CONSIDERATIONS FOR COMPRESSED GAS-POWERED DEVICE APPLICATIONS

Jack Auld discusses the potential of compressed gas as a power source for drug delivery devices, and explains how Altaviz can empower drug developers with the expertise to make full use of this exciting technology.

INJECTION

Marc Beutler

simatec

UNLIMITED POSSIBILITIES BY USING A GAS-PRODUCING DRY CELL

Marc Beutler and Matthias Meier discuss the myriad advantages of using a gas-producing dry cell as a drive system for injectable drug delivery devices, as compared with spring-based and electromechanical drives.

WEARABLES

Cecile Gross

Nemera

OFFERING A SMART AND SUSTAINABLE ON-BODY INJECTOR FOR CHRONICALLY ILL PATIENTS

Cécile Gross discusses the unmet drug delivery needs in chronic diseases, and details how Nemera’s answer – the Symbioze^® on-body injector – fulfils these needs.

WEARABLES

Lauren Orme

West Pharmaceutical Services

THE EVOLUTION OF WEARABLES – REPRESENTING THE VOICE OF THE ENTIRE ECOSYSTEM

Lauren Orme, Victoria Morgan and Shari Krusniak consider the current landscape for on-body delivery systems and discuss how West Pharmaceutical Services is responding to the demands of various stakeholders.

EXPERT VIEW

Tom Oakley

ON-BODY DELIVERY SYSTEMS – NEWS AND TRENDS

Tom Oakley discusses the current state of play in the on-body delivery system space, reviews recent milestones and proposes directions for the future.

WEARABLES

Paolo Golfetto

Stevanato Group

DEVELOPING AN ON-BODY PLATFORM FOR EFFECTIVE POST-OPERATIVE PAIN MANAGEMENT

Paolo Golfetto and Sheldon Moberg discuss a collaboration between Stevanato Group and Bexson Biomedical that meets an urgent unmet patient need.

WEARABLES

Dr Jiunn-Ru Lai

MicroMED Co Ltd

A NEW MEMS ENGINE FOR LARGE-VOLUME SUBCUTANEOUS INJECTORS

Jiunn-Ru Lai, Tsung-Chieh Cheng and Brian Li discuss how MicroMED’s Primary Actuator technology for driving high-volume, high-viscosity injection devices compares with current spring and motor technologies.