Pulmonary & Nasal Drug Delivery50

Issue No #50 June 19th, 2014

Inside the magazine

FORMULATION METHODS & SIZE REDUCTION FOR INHALERS

Hosokawa Micron

FORMULATION METHODS & SIZE REDUCTION FOR INHALERS

Bert Dekens highlights the importance of achieving the correct particle sizes, both for the API and the carrier in formulations for inhalation, and describes some of the available equipment most suited to specific tasks.

THE eFLOW “CLOSED SYSTEM”

THE eFLOW “CLOSED SYSTEM”

Thomas Gallem describes the design and development stages, including the incorporation of human-factors engineering and optimisation for elderly patients, of the company’s eFlow CS nebuliser, which uses a proprietary single-dose drug ampoule as an integral part of the nebuliser handset.

GENERIC PMDI PRODUCT DEVELOPMENT FOR THE US: KEY CONSIDERATIONS

GENERIC PMDI PRODUCT DEVELOPMENT FOR THE US: KEY CONSIDERATIONS

Badre Hammond highlights key considerations and addresses strategies that are believed to reduce risk and ultimately speed up the process for getting a generic pMDI product to the US market.

ARTIFICIAL NEURAL NETWORKS & TISSUE MODELS

Prof Marc Brown

ARTIFICIAL NEURAL NETWORKS & TISSUE MODELS

Marc Brown, Jo Muddle and Professor Clive Page describe the use of artificial neural networks and novel tissue models as methods for formulation candidate screening, selection and characterisation and, in generic product development, for bioequivalence testing.

SCALE-UP & QBD APPROACHES FOR SPRAY-DRIED INHALATION FORMULATIONS

Dr Eunice Costa

SCALE-UP & QBD APPROACHES FOR SPRAY-DRIED INHALATION FORMULATIONS

Eunice Costa, Filipe Neves, Gonçalo Andrade and Conrad Winters describe the strong position of inhalable products in preclinical and clinical pipelines and make the case for formulation-based approaches to enable and enhance pulmonary product development. Spray-drying technology in particular is highlighted as a highly favourable, scalable manufacturing technique for inhalable composite particles.

SCOPING THE DESIGN SPACE FOR GENERIC NASAL SPRAYS

Dr Deborah Huck-Jones

Malvern Panalytical

SCOPING THE DESIGN SPACE FOR GENERIC NASAL SPRAYS

Deborah Huck-Jones and Paul Kippax discuss analytical methods that can be helpful for demonstrating bioequivalence in the development of generic nasal sprays.

RESPIRATORY DRUG DELIVERY (RDD) 2014

CONFERENCE REVIEW

RESPIRATORY DRUG DELIVERY (RDD) 2014

Respiratory Drug Delivery^® celebrated its 25th Anniversary at the El Conquistador Resort in Fajardo, Puerto Rico, from May 4 to May 8, 2014.