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Pulmonary & Nasal Drug Delivery154

Issue No #154 Nov 2023  November 13th, 2023


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Inside the magazine

SMART SCALING FOR SUCCESSFUL CAPSULE-BASED DRY POWDER INHALER FILLING USING DRUM TECHNOLOGIES
PULMONARY
Carolyn Berg
Catalent
SMART SCALING FOR SUCCESSFUL CAPSULE-BASED DRY POWDER INHALER FILLING USING DRUM TECHNOLOGIES
Carolyn Berg, William Chin and Patrick Goncalves discuss the considerations for filling capsules for dry powder inhalers across the various stages of clinical trials and commercialisation, and how to tackle the challenges of scaling up filling processes.
SPRAY DELIVERY: TARGETING PATIENT NEEDS AND EXPECTATIONS WITH PRECISION
PULMONARY
Gladys Corrons-Bouis
Eveon
SPRAY DELIVERY: TARGETING PATIENT NEEDS AND EXPECTATIONS WITH PRECISION
Gladys Corrons-Bouis and Cyril Le Loc’h discuss the use of spray delivery for precise targeting of patient medication.
FUTURE-PROOFING pMDI DESIGN TO FIT A CHANGING MARKET
EXPERT VIEW
Ross Errington
FUTURE-PROOFING pMDI DESIGN TO FIT A CHANGING MARKET
Ross Errington explores how pharmaceutical companies can evolve their pMDI drug products to make them fit for the future considering the several recent regulatory changes that are transforming the landscape of inhalation drugs.
CHALLENGES BESIDES DRUG TARGETING – REGULATORY HURDLES FOR MULTIDOSE NASAL SPRAYS
NASAL
Dr Marie-Christine Klein
URSATEC
CHALLENGES BESIDES DRUG TARGETING – REGULATORY HURDLES FOR MULTIDOSE NASAL SPRAYS
Marie-Christine Klein,  Andreas Bilstein and Rouven Kraus, discuss recent regulatory changes affecting drug-device combination products, using the example of a multidose nasal spray.
THE END OF THE ROAD FOR pMDIs?
EXPERT VIEW
Finn Heraghty
THE END OF THE ROAD FOR pMDIs?
Finn Heraghty and Heather Jameson explore the extent to which the healthcare needs of a population could be covered by the combined use of soft mist inhalers and dry powder inhalers, and discuss the factors that will impact the continued importance of pressurised metered dose inhalers going forward.
BENEFITS OF INNOVATIVE COMPRESSED GAS-POWERED INTRANASAL DRUG DELIVERY DEVICES
PULMONARY
Albie Lavin
Picocyl
BENEFITS OF INNOVATIVE COMPRESSED GAS-POWERED INTRANASAL DRUG DELIVERY DEVICES
Albie Lavin discusses the exciting potential of propellant-driven systems for intranasal delivery, and how Picocyl’s Pico-Cylinders provide the ideal mechanism to take advantage of this potential.
TAKING A DRUG TO FIRST-IN-HUMAN TRIALS IN A BESPOKE DEVICE FOR TARGETED INTRANASAL DELIVERY
EXPERT VIEW
Dr Mark Allen
TAKING A DRUG TO FIRST-IN-HUMAN TRIALS IN A BESPOKE DEVICE FOR TARGETED INTRANASAL DELIVERY
Mark Allen, Andrew Fiorini and Shai Assia discuss the need to develop delivery devices early when formulating nasally delivered drugs for systemic and local action, and a method by which the route to clinic can be made easier, faster and cheaper. 
NASAL DRUG DELIVERY: OVERCOMING CHALLENGES WITH A ROBUST PLATFORM STRATEGY
EXPERT VIEW
Dr Richard Johnson
NASAL DRUG DELIVERY: OVERCOMING CHALLENGES WITH A ROBUST PLATFORM STRATEGY
Richard Johnson explores the changing nasal delivery landscape, highlighting challenges in nasal drug formulation and potential methods to overcome them.
UNLOCKING THE POTENTIAL OF INTRANASAL DRUG DELIVERY
NASAL
Allan Houston
Silgan Dispensing
UNLOCKING THE POTENTIAL OF INTRANASAL DRUG DELIVERY
Allan Houston, Marcel Sachs and Heiko Rolland discuss the healthcare potential of intranasal drug delivery systems and the necessary steps for bringing these solutions to market. 
PERFECT TIMING FOR THE AUTOMATION OF OINDP TESTING
PULMONARY
Adam Smith
Copley Scientific
PERFECT TIMING FOR THE AUTOMATION OF OINDP TESTING
Adam Smith and Clair Brooks take a look at the benefits of automation, focusing on the actuation of metered dose inhalers and multidose nasal sprays/aerosols.
SPRAYTEC LASER DIFFRACTION: ROBUST, REPRODUCIBLE DROPLET SIZE DATA
PULMONARY
Dr Anne Virden
Malvern Panalytical
SPRAYTEC LASER DIFFRACTION: ROBUST, REPRODUCIBLE DROPLET SIZE DATA
Anne Virden discusses the benefits and applications of Malvern Panalytical's Spraytec laser diffraction system for the measurement of spray particles and droplets.
INTERVIEW: RDD EUROPE 2023 REVIEW & RDD 2024 PREVIEW
CONFERENCE SHOWCASE
RDD
INTERVIEW: RDD EUROPE 2023 REVIEW & RDD 2024 PREVIEW
Respiratory Drug Delivery talks with ONdrugDelivery, reviewing highlights of the successful RDD Europe 2023 event, which took place in Antibes, France last May, then describing what’s ahead for RDD 2024, which will take place in Tuscon, AZ, US, next May, including some of the key upcoming deadlines for participants.
EXPLORING THE PERFORMANCE OF LOW-GWP PROPELLANTS
SUSTAINABILITY
Grant Thurston
Proveris Scientific
EXPLORING THE PERFORMANCE OF LOW-GWP PROPELLANTS
Grant Thurston and Lynn Jordan discusses the performance of pressurised metered dose inhaler propellants with a low global warming potential.
CUSTOMISABLE MESH NEBULISER PLATFORMS: VALUE IN COMBINATION PRODUCT DEVELOPMENT
PULMONARY
Edgar Hernan Cuevas Brun
HCmed Innovations
CUSTOMISABLE MESH NEBULISER PLATFORMS: VALUE IN COMBINATION PRODUCT DEVELOPMENT
Edgar Hernan Cuevas Brun and Yuan-Ming Hsu look at the advantages of customisable nebuliser platforms for new combination products.
DEVELOPING AN INHALABLE FORMULATION OF THE FIRST GENERATIVE AI DRUG
PHARMA INSIGHT
Brita Belli
Insilico Medicine
DEVELOPING AN INHALABLE FORMULATION OF THE FIRST GENERATIVE AI DRUG
Brita Belli introduces Insilico Medecine’s inhalable formulation of its AI-designed therapy for the treatment of idiopathic pulmonary fibrosis, its progression through clinical trials and the company’s approach to generative AI in the pharmaceutical space more broadly.
THE IMPORTANCE OF THE BREATHING MANOEUVRE IN NEBULISED THERAPIES
EXPERT VIEW
Carolina Dantas
THE IMPORTANCE OF THE BREATHING MANOEUVRE IN NEBULISED THERAPIES
Carolina Dantas and Ulf Krueger highlight the importance of the breathing manoeuvre in nebulised therapies – and describe a small study designed to test the effectiveness of patient feedback technology when it comes to guiding the inhalation manoeuvre. 
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