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Prefilled Syringes & Injection Devices138

Issue No #138 Oct 2022 October 11th, 2022

Inside the magazine

THE NEW YPSOMATE™ 5.5 – TAKING HANDHELD SELF-INJECTION BEYOND VOLUMES OF 2 ML

THE NEW YPSOMATE™ 5.5 – TAKING HANDHELD SELF-INJECTION BEYOND VOLUMES OF 2 ML

Reto Jost introduces YpsoMate 5.5, the staked-needle-syringe-based, two-step autoinjector for injection volumes in the 2.0–5.5 mL range, and discusses the drivers of the demand for high-volume, high-rate subcutaneous drug delivery using handheld autoinjectors.

INDUSTRIALISATION OF CUSTOMISABLE PRODUCT PLATFORMS IN LIFE SCIENCES

INDUSTRIALISATION

Umit Ismail Tsavous

INDUSTRIALISATION OF CUSTOMISABLE PRODUCT PLATFORMS IN LIFE SCIENCES

Umit Ismail Tsavous, Carsten Köhler and Tom Nägele discuss customisation of product platforms in the life sciences field.

ENLARGING THE VOLUME OF AUTOINJECTORS: TRAVERSING INJECTION BOUNDARIES

Gary Calderwood

ENLARGING THE VOLUME OF AUTOINJECTORS: TRAVERSING INJECTION BOUNDARIES

Gary Calderwood, Raluca Ganea and Gene Rhode Fuensalida Pantig review how the parenteral space has transformed over the past decade and reports how the company’s portfolio of autoinjector technologies has evolved to deliver subcutaneous parenteral drugs of varying formulations, including higher administration volumes.

DEVELOPING, MANUFACTURING AND DELIVERING A FILL-FINISH PILOT LINE FOR TUB-BASED PREFILLED SYRINGES

INDUSTRIALISATION

DEVELOPING, MANUFACTURING AND DELIVERING A FILL-FINISH PILOT LINE FOR TUB-BASED PREFILLED SYRINGES

Jake Canner discusses the latest project arising out of 3P innovation’s partnership with Cambridge Pharma and its sister company Oval Medical Technologies – including the challenges involved and how they were overcome.

ADVANCED DELIVERY DEVICE TECHNOLOGY TO SIMPLIFY THE RECONSTITUTION OF LYOPHILISED DRUGS

Dr Fred Metzmann

ADVANCED DELIVERY DEVICE TECHNOLOGY TO SIMPLIFY THE RECONSTITUTION OF LYOPHILISED DRUGS

Fred Metzmann and Chris Muenzer present Haselmeier’s innovative approach to the development of reconstitution devices that allow easy and convenient administration of freeze-dried biologics.

Interview with Biocorp’s Arnaud Guillet

Interview with Biocorp’s Arnaud Guillet

In this exclusive interview, Arnaud Guillet of Biocorp talks with ONdrugDelivery about connectivity in the injectables space, sharing some of the insights Biocorp has gained from its decade of experience in developing connected drug delivery devices.

ISO 11608: WHAT THE NEW STANDARD MEANS FOR NIS MANUFACTURERS

Cambridge Design Partnership

ISO 11608: WHAT THE NEW STANDARD MEANS FOR NIS MANUFACTURERS

Steve Augustyn looks at ISO 11608 and what it means for needle-based injection device manufacturers.

REALISING REDUCTIONS IN DEAD VOLUMES WITHIN PREFILLED SYRINGES: A MANUFACTURER’S PERSPECTIVE

PREFILLED SYRINGES

Enrico Barichello

Stevanato Group

REALISING REDUCTIONS IN DEAD VOLUMES WITHIN PREFILLED SYRINGES: A MANUFACTURER’S PERSPECTIVE

Enrico Barichello considers the benefits of prefilled syringes, including cost and waste reduction, and looks at the impact and challenges of dead volume within the syringe.

SILICONE-OIL-FREE, COATING-FREE, TUNGSTEN-FREE PREFILLABLE SYRINGES

PREFILLED SYRINGES

SILICONE-OIL-FREE, COATING-FREE, TUNGSTEN-FREE PREFILLABLE SYRINGES

Taras Bredel and Bernd Zeiss present the studies, development, performance and benefits of the Injecto lubrigone plunger stopper combined with the Gerresheimer RTF^® glass syringe – a silicone-oil-free, coating-free, tungsten-free, low-particle prefilled syringe solution for sensitive drug products.

IT’S TIME TO LEVEL UP LYO – INTRODUCING A SWIFT SHIFT IN DUAL-CHAMBER AUTOINJECTOR TECHNOLOGY

Dr Brent Buchine

Windgap Medical

IT’S TIME TO LEVEL UP LYO – INTRODUCING A SWIFT SHIFT IN DUAL-CHAMBER AUTOINJECTOR TECHNOLOGY

Brent Buchine discusses the need for automated, easy-to-use reconstitution devices, especially in lyophilised medications, and introduces Windgap Medical’s technology platforms, which rise to the challenge.

DESIGN STRATEGY & CONSIDERATIONS FOR COMPRESSED GAS-POWERED DEVICE APPLICATIONS

DESIGN STRATEGY & CONSIDERATIONS FOR COMPRESSED GAS-POWERED DEVICE APPLICATIONS

Jack Auld discusses the potential of compressed gas as a power source for drug delivery devices, and explains how Altaviz can empower drug developers with the expertise to make full use of this exciting technology.

UNLIMITED POSSIBILITIES BY USING A GAS-PRODUCING DRY CELL

UNLIMITED POSSIBILITIES BY USING A GAS-PRODUCING DRY CELL

Marc Beutler and Matthias Meier discuss the myriad advantages of using a gas-producing dry cell as a drive system for injectable drug delivery devices, as compared with spring-based and electromechanical drives.

A HIGH-QUALITY AND ROBUST SAFETY SYSTEM FOR HIGH-VOLUME BIOLOGICS AT HOME

PREFILLED SYRINGES

A HIGH-QUALITY AND ROBUST SAFETY SYSTEM FOR HIGH-VOLUME BIOLOGICS AT HOME

Audrey Chandra and Cécile Gross discuss Nemera’s development of a new product for the safe delivery of high-volume biologics at home.

REACHING A NEW ZENITH IN PROTECTING LARGER-VOLUME SENSITIVE MOLECULES, FROM FILLING TO SELF-ADMINISTRATION

PREFILLED SYRINGES

Victoria Morgan

West Pharmaceutical Services

REACHING A NEW ZENITH IN PROTECTING LARGER-VOLUME SENSITIVE MOLECULES, FROM FILLING TO SELF-ADMINISTRATION

Victoria Morgan and Eric Kurtz, discuss how West Pharmaceutical Services' Daikyo Crystal Zenith™ insert needle prefilled syringe system meets the needs presented by the healthcare sector’s shift to home-based care and the increasing prevalence of biologics in the pharmaceutical pipeline.

OVERCOMING THE CHALLENGES OF ULTRA-LARGE-VOLUME SUBCUTANEOUS INFUSIONS

KORU Medical Systems

OVERCOMING THE CHALLENGES OF ULTRA-LARGE-VOLUME SUBCUTANEOUS INFUSIONS

Rob Limouze looks at the obstacles facing ultra-large-volume subcutaneous infusion drug delivery and highlights how the KORU Freedom infusion system meets these challenges.

AUTOINJECTORS: HISTORICAL ACHIEVEMENTS & COMPELLING NEEDS DRIVING NEXT-GENERATION DEVICES

Richard Whelton

AUTOINJECTORS: HISTORICAL ACHIEVEMENTS & COMPELLING NEEDS DRIVING NEXT-GENERATION DEVICES

Richard Whelton and Philip Green summarise the history of autoinjectors, highlight success stories to date, review the unmet needs that remain and consider emerging needs that could drive continued innovation in autoinjectors to ensure safety, patient satisfaction and pharma commercial success.

COMPANY SHOWCASE: Owen Mumford Pharmaceutical Services

PREFILLED SYRINGES

COMPANY SHOWCASE: Owen Mumford Pharmaceutical Services

Owen Mumford Pharmaceutical Services specialises in the design, development and manufacture of injectable drug delivery systems for the pharma, biotech and generics industries. Its trusted devices are used daily in the delivery of various medications for a multitude of conditions across the globe.

Technology Showcase: Investigation into the Feasibility of a 2 mL Needle-Free Injector

Portal Instruments

Technology Showcase: Investigation into the Feasibility of a 2 mL Needle-Free Injector

Portal Instruments showcases its Prime needle-free drug delivery platform, and makes the case that there is a significant opportunity to transform the patient experience with a reusable and connected needle-free injector.

Technology Showcase: I-Platform from CCBio – How to Upgrade a Device in One Platform

Technology Showcase: I-Platform from CCBio – How to Upgrade a Device in One Platform

CCBio showcases its I-Platform injectable drug delivery solution comprising: delivery units, including the electronic, connected Tesla device; containers and adapters; and safety needles.

PRODUCT SHOWCASE: Aktiv Pharma’s ARAI Autoinjector Platform

Aktiv Pharma Group

PRODUCT SHOWCASE: Aktiv Pharma’s ARAI Autoinjector Platform

Aktiv Pharma showcases its ARAI autoinjector platform, which is powered by pressurised CO₂ and incorporates the company's proprietary glass-free flexible primary container made from high-barrier films, in a form of blister package, named ARCH.

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