RESPIRATORY

PULMONARY

BENEFITS OF INNOVATIVE COMPRESSED GAS-POWERED INTRANASAL DRUG DELIVERY DEVICES

Albie Lavin discusses the exciting potential of propellant-driven systems for intranasal delivery, and how Picocyl’s Pico-Cylinders provide the ideal mechanism to take advantage of this potential.

PULMONARY

SPRAYTEC LASER DIFFRACTION: ROBUST, REPRODUCIBLE DROPLET SIZE DATA

Anne Virden discusses the benefits and applications of Malvern Panalytical's Spraytec laser diffraction system for the measurement of spray particles and droplets.

PULMONARY

Carolyn Berg

Catalent

SMART SCALING FOR SUCCESSFUL CAPSULE-BASED DRY POWDER INHALER FILLING USING DRUM TECHNOLOGIES

Carolyn Berg, William Chin and Patrick Goncalves discuss the considerations for filling capsules for dry powder inhalers across the various stages of clinical trials and commercialisation, and how to tackle the challenges of scaling up filling processes.

PULMONARY

Gladys Corrons-Bouis

Eveon

SPRAY DELIVERY: TARGETING PATIENT NEEDS AND EXPECTATIONS WITH PRECISION

Gladys Corrons-Bouis and Cyril Le Loc’h discuss the use of spray delivery for precise targeting of patient medication.

EXPERT VIEW

Ross Errington

FUTURE-PROOFING pMDI DESIGN TO FIT A CHANGING MARKET

Ross Errington explores how pharmaceutical companies can evolve their pMDI drug products to make them fit for the future considering the several recent regulatory changes that are transforming the landscape of inhalation drugs.

NASAL

Dr Marie-Christine Klein

URSATEC

CHALLENGES BESIDES DRUG TARGETING – REGULATORY HURDLES FOR MULTIDOSE NASAL SPRAYS

Marie-Christine Klein,  Andreas Bilstein and Rouven Kraus, discuss recent regulatory changes affecting drug-device combination products, using the example of a multidose nasal spray.

EXPERT VIEW

Finn Heraghty

THE END OF THE ROAD FOR pMDIs?

Finn Heraghty and Heather Jameson explore the extent to which the healthcare needs of a population could be covered by the combined use of soft mist inhalers and dry powder inhalers, and discuss the factors that will impact the continued importance of pressurised metered dose inhalers going forward.

EXPERT VIEW

Dr Mark Allen

TAKING A DRUG TO FIRST-IN-HUMAN TRIALS IN A BESPOKE DEVICE FOR TARGETED INTRANASAL DELIVERY

Mark Allen, Andrew Fiorini and Shai Assia discuss the need to develop delivery devices early when formulating nasally delivered drugs for systemic and local action, and a method by which the route to clinic can be made easier, faster and cheaper. 

EXPERT VIEW

Dr Richard Johnson

NASAL DRUG DELIVERY: OVERCOMING CHALLENGES WITH A ROBUST PLATFORM STRATEGY

Richard Johnson explores the changing nasal delivery landscape, highlighting challenges in nasal drug formulation and potential methods to overcome them.

NASAL

Allan Houston

Silgan Dispensing

UNLOCKING THE POTENTIAL OF INTRANASAL DRUG DELIVERY

Allan Houston, Marcel Sachs and Heiko Rolland discuss the healthcare potential of intranasal drug delivery systems and the necessary steps for bringing these solutions to market. 

PULMONARY

Adam Smith

Copley Scientific

PERFECT TIMING FOR THE AUTOMATION OF OINDP TESTING

Adam Smith and Clair Brooks take a look at the benefits of automation, focusing on the actuation of metered dose inhalers and multidose nasal sprays/aerosols.

CONFERENCE SHOWCASE

RDD

INTERVIEW: RDD EUROPE 2023 REVIEW & RDD 2024 PREVIEW

Respiratory Drug Delivery talks with ONdrugDelivery, reviewing highlights of the successful RDD Europe 2023 event, which took place in Antibes, France last May, then describing what’s ahead for RDD 2024, which will take place in Tuscon, AZ, US, next May, including some of the key upcoming deadlines for participants.

SUSTAINABILITY

Grant Thurston

Proveris Scientific

EXPLORING THE PERFORMANCE OF LOW-GWP PROPELLANTS

Grant Thurston and Lynn Jordan discusses the performance of pressurised metered dose inhaler propellants with a low global warming potential.

PULMONARY

Edgar Hernan Cuevas Brun

HCmed Innovations

CUSTOMISABLE MESH NEBULISER PLATFORMS: VALUE IN COMBINATION PRODUCT DEVELOPMENT

Edgar Hernan Cuevas Brun and Yuan-Ming Hsu look at the advantages of customisable nebuliser platforms for new combination products.

PHARMA INSIGHT

Brita Belli

Insilico Medicine

DEVELOPING AN INHALABLE FORMULATION OF THE FIRST GENERATIVE AI DRUG

Brita Belli introduces Insilico Medecine’s inhalable formulation of its AI-designed therapy for the treatment of idiopathic pulmonary fibrosis, its progression through clinical trials and the company’s approach to generative AI in the pharmaceutical space more broadly.

EXPERT VIEW

Carolina Dantas

THE IMPORTANCE OF THE BREATHING MANOEUVRE IN NEBULISED THERAPIES

Carolina Dantas and Ulf Krueger highlight the importance of the breathing manoeuvre in nebulised therapies – and describe a small study designed to test the effectiveness of patient feedback technology when it comes to guiding the inhalation manoeuvre. 

SUSTAINABILITY

Marc Severin

H&T Presspart

DRIVING SUSTAINABLE DRUG DELIVERY DEVICES WITH CONTINUOUS IMPROVEMENT PROCESSES

Marc Severin discusses the H&T Excellence programme and how it has been expanded to include methods and training to help H&T Presspart identify environmental impact at a product group level and take co-ordinated action to reduce carbon emissions across the organisation.

EXPERT VIEW

Tom Oakley

“A CHILD IS NOT A SMALL ADULT”: CHALLENGES AND SOLUTIONS IN DEVELOPING DRUG DELIVERY DEVICES FOR CHILDREN

Tom Oakley and Heather Jameson consider the main differences in developing therapies and drug delivery devices for children and babies when compared with adults.

INDUSTRIALISATION

Mark Foster

Oliver Design

WHEN SECONDARY PACKAGING IS A PRIMARY CONCERN

Mark Foster discusses the challenges to optimising primary and secondary packaging for parenteral drug delivery devices, including higher level challenges from the patient perspective, as well as how these challenges present opportunities for device developers to stand out in the market.

EXPERT VIEW

Roger Bohannan

INJECTING INNOVATIVE SOLUTIONS INTO CONNECTED DELIVERY DEVICES

Roger Bohannan discusses the capabilities and design challenges of connected drug delivery devices.

INTERVIEW

Julien Martins

Paragon Medical

Interview with Julien Martins & David Philbrick

Julien Martins and David Philbrick talk exclusively with ONdrugDelivery's Guy Furness. They discuss a wide range of topics, including the services Paragon Medical provides the drug delivery industry, its wider business operations, the company’s expanded facilities in the US and Europe, and its new Advanced Surgical Innovation Center.

EXPERT VIEW

Carolina Dantas

THE POTENTIAL OF CONNECTIVITY AND MONITORING IN MESH NEBULISERS

Carolina Dantas and Ulf Krueger review the current connectivity and remote monitoring capabilities in mesh nebulisers – and their potential to impact patients’ healthcare journeys and the clinical development of inhaled therapies.

EXPERT VIEW

Will Davies

DESIGNING SUSTAINABILITY INTO PHARMACEUTICAL DEVICES

Will Davies discusses in detail how to address the challenges of designing sustainability into pharmaceutical devices.

EXPERT VIEW

Tim Wooller

SUSTAINABILITY IN DRUG DELIVERY: HOW DO WE GET THERE?

Tim Wooller discusses the urgent need to transition away from disposable models of drug delivery device design and move towards reusables, providing insights into the reasons why and the methods by which this can be achieved.

NASAL

Séverine Duband

Nemera

ACCELERATING THE GO-TO-MARKET OF NASAL COMBINATION PRODUCTS WITH INTEGRATED SOLUTIONS

Séverine Duband and Audrey Chandra discuss emerging trends in the ear, nose and throat market and how Nemera can assist in bringing new devices to market.

SUSTAINABILITY

Chris Baron

Aptar Pharma

NAVIGATING pMDI REFORMULATION 2.0

Chris Baron and William Ganley examine possible responses to the environmental impact of pressurised metered dose inhalers use and consider alternative inhaler types, with a focus on the strategies and support that can accelerate the development of the next generation of pMDIs.

NASAL

Joe Neale

Recipharm

NAVIGATING THE CHALLENGES OF BRINGING INTRANASAL DRUG FORMULATIONS & DEVICES TO PATIENTS

Joe Neale and Ross Errington explore the obstacles and opportunities facing the intranasal drug delivery market and how manufacturers can overcome them by harnessing innovative platforms like Unidose^® Xtra.

PULMONARY

Dr Marie-Christine Klein

URSATEC

THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES

Marie-Christine Klein, Andreas Bilstein and Caroline Hoffmann discuss the underlying techniques involved in the use of metered pump-based soft mist devices and their application diversity.

PULMONARY

Dr Orest Lastow

Iconovo

NOVEL INDUSTRIAL-SCALE ELECTROSTATIC CHARGE ELIMINATION METHOD FOR INHALATION PRODUCTS

Orest Lastow describes a novel technique for removing the built-up charge from dry powder inhaler components, offering a potential solution to the issues caused by static charges in these devices, including decreased performance, altered powder properties and increased variability in delivered dose.

PULMONARY

Dr Mirjam Kobler

H&T Presspart

DEVELOPMENT APPROACH FOR A HIGH-PERFORMANCE CAPSULE-BASED DPI

Mirjam Kobler, Ameet Sule and Sunita Sule look at the factors affecting the performance of dry powder inhalers and discuss the company’s development of high-performance prototypes.

PULMONARY

Andy Cleall

3P Innovation

ARE YOU STRUGGLING TO PUT DIFFICULT POWDERS INTO CAPSULES?

Andy Cleall and Ben Smith discuss process optimisation and cutting-edge technology for powder filling, including how 3P’s R500 and R1000 robotic capsule fillers are pushing the boundaries of optimal filling and how its Fill2Weight technology enables increased filling accuracy and improved yields.

NASAL

Dr Julie Suman

Aptar Pharma

THE POTENTIAL AND THE CHALLENGES OF NASAL VACCINATION

Julie Suman and Nektaria Karavas discuss the challenges and opportunities of intranasal vaccination – showcasing current understanding for both liquid and powder products. Experimental studies highlight critical issues, the performance of commercially available devices and developments in formulation practice.

PULMONARY

Dr Rui Churro

Hovione

CAPSULE FILLING FOR DPIs – LINKING PROCESS SCALES THROUGH ADVANCED CHARACTERISATION AND QUALITY BY DESIGN

 Rui Churro, Carolina Lopes and João Pires discuss the value of rheological characterisation of powders to expedite and de-risk the scale-up of DPI capsule-filling processes.

PULMONARY

Dr Jasdip Koner

Aston Particle Technologies

ISOTHERMAL DRY PARTICLE COATING – BACK TO THE FUTURE?

Jasdip Koner, Abdul Ershad and David Wyatt introduce Aston Particle Technologies’ novel dry powder processing technology – isothermal dry particle coating (iDPC™) – explaining how it has the capacity to enhance and broaden the scope of what dry powder formulations can achieve in respiratory medicine.

EXPERT VIEW

Matt Jones

DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION

Matt Jones and Rob Veasey consider the process of matching the drug with the right delivery device and look at the importance of due diligence when “licensing in” technology.

EXPERT VIEW

Mark Parry

CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS

Mark Parry discusses the considerations that need to be made when switching from current pressurised metered dose inhaler propellants to new alternatives with lower global warming potential, including formulation, regulatory and analytical standpoints.

INTERVIEW

Dr Ben Cox

Team Consulting

Pharmapack Expert Panel on Patient-Centric Digital Health: Interview with Ben Cox, Team Consulting

With Pharmapack returning to its traditional February timing in 2023, Team Consulting will be chairing a Day 1 expert panel discussion on patient-centric digital health solutions. Interviewed here, Ben Cox provides insight into trends the panel will discuss, lays out the current status of the industry with respect to digital health and considers what to look forward to at Pharmapack this year.

CONNECTIVITY

Edgar Hernan Cuevas Brun

HCmed Innovations

ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER

Edgar Hernan Cuevas Brun and Yuan-Ming Hsu consider patient adherence and the role HCmed Innovations’ AdheResp mesh nebuliser plays in monitoring adherence.