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Novel Oral Delivery Systems77

Issue No #77  July 1st, 2017


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Issue 77 - July 2017

Inside the magazine

ADVANCED APPROACHES FOR DELAYED-RELEASE FORMULATIONS
GI/ORAL
Dr Maria Montero Mirabet
Evonik
ADVANCED APPROACHES FOR DELAYED-RELEASE FORMULATIONS
Maria Montero Mirabet and Brigitte Skalsky, both of Evonik Health Care, review advances in delayed-release technology including advances in enteric-coating applications and the use of pulsatile technology to provide tailored lag times.
MEETING THE CHALLENGES OF PAEDIATRIC DOSING
GI/ORAL
Don Barbieri
MEETING THE CHALLENGES OF PAEDIATRIC DOSING
Although paediatric drugs are traditionally administered in a liquid formulation, recent studies suggest that orally disintegrating mini-tablets may be a more accurate, convenient and less messy dosage form. Don Barbieri explores this method and reviews two case studies looking at whether quality standards can be met and the importance of taste in paediatric formulations.
EVALUATING A NEW MICROSPHERE BASED CONTROLLED-RELEASE DELIVERY SYSTEM
EXPERT VIEW
Dr S Mohan Mohanraj
EVALUATING A NEW MICROSPHERE BASED CONTROLLED-RELEASE DELIVERY SYSTEM
S Mohan Mohanraj and Meir Kende discuss the development of a microsphere based delivery system for an orally administered anthrax vaccine.
THE PRESCRIPTION ABUSE EPIDEMIC: DESIGNING A SOLUTION
GI/ORAL
Aia Malik
THE PRESCRIPTION ABUSE EPIDEMIC: DESIGNING A SOLUTION
Aia Malik and Gemma Budd discuss the journey behind Lucideon’s proprietary iCRTdeter technology which provides tamper-proofing and enhanced safety of pharmaceuticals. It has been used to give abuse-deterrent features to formulations of opioids and highly potent compounds.
ORALLY DISINTEGRATING FILMS FOR THE DELIVERY OF BIOTHERAPEUTICS & NANO / MICROPARTICLE FORMULATIONS
GI/ORAL
Dr Carmen Popescu
Roquette
ORALLY DISINTEGRATING FILMS FOR THE DELIVERY OF BIOTHERAPEUTICS & NANO / MICROPARTICLE FORMULATIONS
Carmen Popescu summarises the benefits and applications of orally dissolving film dosage forms, with claims supported by two case studies, one demonstrating the suitability of ODFs for the delivery of micro and nanoparticles, the other showing how this property of ODFs exhibits promise as a next-generation immunisation system.
SINGLE-STEP FUNCTIONAL COATINGS FOR INCREASED EFFICIENCIES
GI/ORAL
Dr Nathan Dormer
SINGLE-STEP FUNCTIONAL COATINGS FOR INCREASED EFFICIENCIES
In this article about oral drug innovation, Cory Berkland and Nathan Dormer focus on how enterics and reverse enterics are applied into dosage forms, and discuss the future of this class of drug formulation technology.
OPPORTUNITIES & INNOVATIONS IN COLONIC DRUG DELIVERY
GI/ORAL
Dr Sejal R Ranmal
OPPORTUNITIES & INNOVATIONS IN COLONIC DRUG DELIVERY
Sejal R Ranmal, Vipul Yadav and Abdul W Basit describe recent insights into the physiology of the colon, advantages of targeting drug release to the colon and introduce Phloral®, Intract’s unique system for achieving drug release in the colon successfully and consistently.
TECHNOLOGIES & CLINICAL STUDIES FOR THE ORAL DELIVERY OF CALCITONIN
EXPERT VIEW
Dr Nozer Mehta
TECHNOLOGIES & CLINICAL STUDIES FOR THE ORAL DELIVERY OF CALCITONIN
Nozer Mehta, James P Gilligan and William Stern summarise the different technologies that have been in development for oral delivery of peptides through the gastro-intestinal mucosal surfaces via the transcellular or the paracellular pathways and describe the results of several long-term clinical studies on the oral delivery of salmon calcitonin.
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