GI/ORAL

GI/ORAL

CHALLENGES AND ACHIEVEMENTS OF TIO₂ REPLACEMENT IN HARD CAPSULES

Susana Ecenarro Probst looks at the issues arising in replacing TiO₂ in hard capsules and introduces Qualicaps' alternative hard capsule formulation.

GI/ORAL

POWDER CHARACTERISATION FOR PHARMACEUTICALS: BEYOND STANDARDS

Aurélien Neveu, Marco Lupo and Filip Francqui discuss the limitations of current standardised procedures for assessing the properties of pharmaceutical powders and how Granutools’ instruments – GranuPack and GranuHeap – offer a significant improvement.

GI/ORAL

Dr Keat Theng Chow

Roquette

TREATING THE NEXT GENERATION: THE UNTAPPED POTENTIAL OF ORALLY DISPERSIBLE FILMS

Keat Theng Chow explores the latest scientific thinking on orally dispersible film formulation, and how these advancements could open a new chapter in paediatric patient compliance.

GI/ORAL

Dr Bettina Hölzer

Evonik

PRODUCT SHOWCASE: Optimising Gastric Resistance in Complex Oral Drug Products with Novel, Functional, Ready-To-Fill Capsules

Evonik showcases its novel, functional, ready-to-fill capsules portfolio, EUDRACAP^®, explaining how its role in optimising gastric resistance in complex oral drug products.

GI/ORAL

Dr Aruna Railkar

Quotient Sciences

STRATEGIES FOR STREAMLINING THE DEVELOPMENT OF COMPLEX ORAL DRUG PRODUCTS

Aruna Railkar presents three case studies – one involving solubility enhancement, one modified release, and a paediatric dosage form – to illustrate the formulation challenges in complex drug programmes.

EXPERT VIEW

Dr Jonathan Cape

MODIFIED-RELEASE MICROSPHERES: MAXIMISING COATING INTEGRITY AND OPTIMISING RELEASE

Jonathan Cape discusses development considerations and workflows to select optimal enteric coat weights for modified release microspheres – balancing performance considerations with API stability and the excipient burden to patients.

EXPERT VIEW

Richard Ball

INCREASE PRODUCTION SUCCESS THROUGH TABLET DESIGN TECHNIQUES

Richard Ball considers the important features of tablet design and discusses its importance to the mass production of tablets.

EXPERT VIEW

Dr Jnanadeva Bhat

HARD CAPSULES: A HOLISTIC APPROACH FOR ORAL DRUG DELIVERY AND FORMULATION

Jnanadeva Bhat and Manali Dalvi discuss how advances in capsule technology as an oral drug delivery method have opened up new avenues for the development of more effective and patient-friendly drugs.

SKIN

Dr Claire Authesserre

Eveon

AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST

Claire Authesserre and Florian Corne discuss the current challenges faced by the topical spray-based delivery of therapeutics and how EVEON’s Ad-Mist™ spray nozzle overcomes these challenges to harness the potential of this delivery route.

INDUSTRIALISATION

MG2

NEXT-GENERATION CAPSULE FILLING: MG2 AND THE DM² PROJECT

MG2 introduces the UK Made Smarter Innovation - Digital Medicine Manufacturing (DM²) Research Centre, which it has recently joined as an industrial partner, and describes how it will develop an AI-driven microscale capsule filling system for the selection of formulation and process parameters. 

ROUNDTABLE

Michael Morgan

Lonza

ROUNDTABLE: TRENDS AND INNOVATIONS IN ORAL DRUG DELIVERY

Michael Morgen of Lonza Bend, Torkel Gren of Recipharm, and Yogesh Sadhale of Metrics Contract Services, discuss the current trends and innovations influencing oral drug delivery development and what their respective companies can offer to pharma in this space.

GI/ORAL

Dr Aurelien Neveu

Granutools

INFLUENCE OF ADDITIVES ON THE ELECTROSTATIC CHARGE BUILD-UP OF EXCIPIENTS

Aurélien Neveu, Devang Patel and Filip Francqui present a study investigating the influence of additives on the tribocharging behaviour of two excipients using Granutools’ GranuCharge instrument.

GI/ORAL

Oksana Lemasson

Skyepharma Production

NANOENCAPSULATION: A NEW ERA FOR ORAL SOLID DOSAGE FORMS

Oksana Lemasson, Sandrine Bourgeois and Vanessa Bourgeaux discuss the performance of the NanoMicS platform for the oral administration of nanoparticles.

EXPERT VIEW

Rina Chokshi

FORMULATING SUPERIOR ORAL SUSPENSIONS FOR BETTER PATIENT COMPLIANCE

Rina Chokshi and Dago Caceres discuss how leveraging key ingredients in oral suspensions can enhance stability and sensory attributes, as well as encourage patient compliance.

INJECTION

Bill Welch

Picocyl

ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY

William Welch considers the evolution of compressed gas alternatives to spring power for single-use drug delivery devices.

EXPERT VIEW

Dr Jnanadeva Bhat

CAPSULES: CLASSIC DRUG DELIVERY FORM HOLDS POTENTIAL FOR SUSTAINABLE DELIVERY

Jnanadeva Bhat and Anita Solanki discuss the role that hard capsules are able to play in delivering a more sustainable pharmaceutical industry, both as an oral solid dosage form and in dry powder inhalers.

GI/ORAL

Dr Jessica Mueller-Albers

Evonik

The Secrets of Solubility Enhancement Success with EUDRAGIT^® Carriers

Jessica Mueller-Albers discusses how Evonik’s EUDRAGIT^® functional polymers can enhance drug solubility and permeability, with a focus on carriers, screening tools and manufacturing processes.

GI/ORAL

Frédérique Bordes-Picard

Lonza

REMOVING CLINICAL TRIAL BIAS WITH OVER-ENCAPSULATION

Frédérique Bordes-Picard, Julien Lamps and Stephen Rode discuss the considerations to take into account when using over-encapsulation to blind clinical trials, including the advantages of hydroxypropyl methylcellulose over gelatin as a material.

EARLY INSIGHT

Dr Sashi Kesavapany

LiberaTx

GASTRIC FLOATING MICROCAPSULES FOR THE MANAGEMENT OF PARKINSON’S DISEASE

Kaarunya Sampathkumar, Joachim Loo and Sashi Kesavapany discuss current treatments for Parkinson’s disease and introduce an extended-releasing technology for polypharmacy oral formulations.

GI/ORAL

Niklas Sandler

Nanoform

NANOPARTICLE ENGINEERING AND 3DP DELIVERY FOR GAME-CHANGING ORAL THERAPEUTICS

Niklas Sandler and Thomas West consider the technological advances in nanoparticle engineering that can improve the bioavailability and delivery of oral therapeutics.

GI/ORAL

Laura Canalejas

Qualicaps

FORMULATION SOLUTION FOR MOISTURE-SENSITIVE DRUGS

Laura Canalejas outlines the benefits of Quali-V^® Extra Dry – a hypromellose capsule designed for moisture-sensitive formulations.

GI/ORAL

Gary Pond

Colorcon

SMARTER MEDICINES TO SECURE PRODUCTS AND PROMOTE PATIENT ENGAGEMENT

Gary Pond looks at digital authentication and discusses how on-dose microtaggants can provide a high level of security in authenticating tablets and capsules in the fight against counterfeit products.

EXPERT VIEW

Dr Stephanie Emory

ADDRESSING ONGOING AND NEW BIOAVAILABILITY CHALLENGES

Stephanie Emory explores the pros and cons of various technologies for enhancing solubility and bioavailability for oral drug formulations. Further, Dr Emory draws on her experience as a reviewer at the US FDA to discuss how developers can view the FDA as a partner to aid success when leveraging innovative approaches.

GI/ORAL

Evonik

PRODUCT SHOWCASE: Evonik’s newly launched EUDRACAP™ functional, ready-to-fill capsules

Evonik introduces EUDRACAP™, its newly launched platform of functional ready-to-fill HPMC capsules, which helps optimise release profile, protects sensitive active ingredients, and speeds time to market.

EXPERT VIEW

Jamie Clayton

ANALYTICAL TECHNIQUES FOR THE FORMULATION OF GASTRORETENTIVE TABLETS

Jamie Clayton, Phil Bone and Kyu Mok Hwang discuss the value of analyses such as mercury porosimetry and powder rheology in characterising excipients for gastroretentive tablet formulation, and go on to detail a case study investigating polymer excipients for a novel bilayer floating tablet.

EXPERT VIEW

Mr John Ross

LINKING THE “D” & “M” IN CDMO

John Ross looks at the role of CDMOs in product development through to commercialisation and considers the benefits of consolidated “DM” models.

INTERVIEW

Steve Amoussou-Guenou

Roquette

INTERVIEW WITH STEVE AMOUSSOU-GUENOU, ROQUETTE

In this interview, Steve Amoussou-Guenou discusses how Roquette developed the LYCAGEL™ system and how this plant-based alternative compares with traditional gelatin softgel capsules.

SUSTAINABILITY

Jiae Kim

Roquette

INTRODUCING ISOSORBIDE: A SUSTAINABLE, SAFE, HIGH-PERFORMANCE, PLANT-BASED FEEDSTOCK FOR PACKAGING

Jiae Kim introduces isosorbide, a plant starch-derived diol made from renewable feedstock that has wide ranging applications across polymer materials for a variety of industries.

INDUSTRIALISATION

Bert Dekens

Hosokawa Micron BV

ONE-STOP SHOP FOR TOTAL MIXING SOLUTIONS FOR PHARMACEUTICAL MANUFACTURERS

Bert Dekens discusses Hosokawa Micron's offering for pharmaceutical powder mixing, including the Cyclomix high-shear mixer and the Nauta low-shear mixer, and how the company’s technology solutions take a broader approach to the full mixing process than simply providing a mixing machine.

EXPERT VIEW

Rina Chokshi

SUSTAINABLE PHARMACEUTICALS CAN OUTPERFORM THROUGH NATURALLY DERIVED INGREDIENTS & DEEP EXPERTISE

Rina Chokshi discusses the benefits of naturally derived, sustainable ingredients and their benefits to the environment and pharmaceutical industry.

SUSTAINABILITY

Dr Aline Moulin

Skyepharma Production

LEADING PHARMACEUTICAL DEVELOPMENT IN A SUSTAINABLE WAY – SKYEPHARMA’S EXAMPLE

Aline Moulin and Laurent Rigaudeau discuss how Skyepharma fulfils its sustainable development policy through its technologies and processes.

SUSTAINABILITY

Andrea Cusack

leon-nanodrugs

NANOTECHNOLOGY: A PATHWAY FOR SUSTAINABLE INNOVATION IN DRUG DEVELOPMENT

Andrea Cusack discusses how, by using bottom-up nanotechnology techniques, efficiencies can be found both in the development of new chemical entities and in the repurposing of existing drugs, and how these efficiencies translate into reduced energy requirements and therefore more sustainable industry practices.

ROUNDTABLE

Dr Jeremy Drummond

ROUNDTABLE: JEREMY DRUMMOND, MEDPHARM; STEPHEN RODE, LONZA; AND TORKEL GREN, RECIPHARM

In this roundtable discussion, Jeremy Drummond, Stephen Rode and Torkel Gren discuss trends with different drug dosage forms for different routes of administration, the rise of patient centricity including the shift from the blockbuster model to more tailored products.

COVID-19 NEWS

TFF AND UNION AGREE LICENSING PACT FOR TFF TECHNOLOGY WITH NICLOSAMIDE FOR THE TREATMENT OF COVID-19

UNION therapeutics has acquired an option to a worldwide, exclusive licence to TFF Pharmaceuticals' Thin Film Freezing (TFF) technology, in combination with niclosamide, covering oral and inhalation formulations, potentially for covid-19, as well as other niclosamide-based therapies.

GI/ORAL

Graeme Macleod

SPI Pharma

MAKING MEDICINE EASIER TO TAKE

Graeme Macleod and Wayne Camarco discuss the rational design of excipients to meet the needs of patient-centric formulations.

GI/ORAL

Sanjay Powale

ACG

FORMULATION FLEXIBILITY WITH NEW ERA HPMC CAPSULES

Sanjay Powale, Anita Solanki and Dorene Almeida discuss the benefits of HPMC capsules in overcoming challenges faced by traditional gelatin capsules.

GI/ORAL

Dr Aurelien Neveu

Granutools

THE FLOWABILITY OF LACTOSE POWDERS TO OPTIMISE TABLETING PROCESSES

Aurélien Neveu, Pauline Janssen and Geoffroy Lumay discuss how new measurement methods can help gain a better understanding of the flowability of lactose powders – a necessary step for future improvement of oral delivery systems.

GI/ORAL

Dr Satu Lakio

Nanoform

NANOPARTICLE ENGINEERING: REVOLUTIONISING ORAL DRUG DEVELOPMENT & DELIVERY

Satu Lakio and Niklas Sandler discuss the benefits of nanoparticle engineering technology as a means of improving the bioavailability and solubility of drug compounds.