PULMONARY

PULMONARY

PERFECT TIMING FOR THE AUTOMATION OF OINDP TESTING

Adam Smith and Clair Brooks take a look at the benefits of automation, focusing on the actuation of metered dose inhalers and multidose nasal sprays/aerosols.

PULMONARY

CUSTOMISABLE MESH NEBULISER PLATFORMS: VALUE IN COMBINATION PRODUCT DEVELOPMENT

Edgar Hernan Cuevas Brun and Yuan-Ming Hsu look at the advantages of customisable nebuliser platforms for new combination products.

PULMONARY

Carolyn Berg

Catalent

SMART SCALING FOR SUCCESSFUL CAPSULE-BASED DRY POWDER INHALER FILLING USING DRUM TECHNOLOGIES

Carolyn Berg, William Chin and Patrick Goncalves discuss the considerations for filling capsules for dry powder inhalers across the various stages of clinical trials and commercialisation, and how to tackle the challenges of scaling up filling processes.

PULMONARY

Gladys Corrons-Bouis

Eveon

SPRAY DELIVERY: TARGETING PATIENT NEEDS AND EXPECTATIONS WITH PRECISION

Gladys Corrons-Bouis and Cyril Le Loc’h discuss the use of spray delivery for precise targeting of patient medication.

EXPERT VIEW

Ross Errington

FUTURE-PROOFING pMDI DESIGN TO FIT A CHANGING MARKET

Ross Errington explores how pharmaceutical companies can evolve their pMDI drug products to make them fit for the future considering the several recent regulatory changes that are transforming the landscape of inhalation drugs.

EXPERT VIEW

Finn Heraghty

THE END OF THE ROAD FOR pMDIs?

Finn Heraghty and Heather Jameson explore the extent to which the healthcare needs of a population could be covered by the combined use of soft mist inhalers and dry powder inhalers, and discuss the factors that will impact the continued importance of pressurised metered dose inhalers going forward.

PULMONARY

Albie Lavin

Picocyl

BENEFITS OF INNOVATIVE COMPRESSED GAS-POWERED INTRANASAL DRUG DELIVERY DEVICES

Albie Lavin discusses the exciting potential of propellant-driven systems for intranasal delivery, and how Picocyl’s Pico-Cylinders provide the ideal mechanism to take advantage of this potential.

PULMONARY

Dr Anne Virden

Malvern Panalytical

SPRAYTEC LASER DIFFRACTION: ROBUST, REPRODUCIBLE DROPLET SIZE DATA

Anne Virden discusses the benefits and applications of Malvern Panalytical's Spraytec laser diffraction system for the measurement of spray particles and droplets.

CONFERENCE SHOWCASE

RDD

INTERVIEW: RDD EUROPE 2023 REVIEW & RDD 2024 PREVIEW

Respiratory Drug Delivery talks with ONdrugDelivery, reviewing highlights of the successful RDD Europe 2023 event, which took place in Antibes, France last May, then describing what’s ahead for RDD 2024, which will take place in Tuscon, AZ, US, next May, including some of the key upcoming deadlines for participants.

SUSTAINABILITY

Grant Thurston

Proveris Scientific

EXPLORING THE PERFORMANCE OF LOW-GWP PROPELLANTS

Grant Thurston and Lynn Jordan discusses the performance of pressurised metered dose inhaler propellants with a low global warming potential.

PHARMA INSIGHT

Brita Belli

Insilico Medicine

DEVELOPING AN INHALABLE FORMULATION OF THE FIRST GENERATIVE AI DRUG

Brita Belli introduces Insilico Medecine’s inhalable formulation of its AI-designed therapy for the treatment of idiopathic pulmonary fibrosis, its progression through clinical trials and the company’s approach to generative AI in the pharmaceutical space more broadly.

EXPERT VIEW

Carolina Dantas

THE IMPORTANCE OF THE BREATHING MANOEUVRE IN NEBULISED THERAPIES

Carolina Dantas and Ulf Krueger highlight the importance of the breathing manoeuvre in nebulised therapies – and describe a small study designed to test the effectiveness of patient feedback technology when it comes to guiding the inhalation manoeuvre. 

SUSTAINABILITY

Marc Severin

H&T Presspart

DRIVING SUSTAINABLE DRUG DELIVERY DEVICES WITH CONTINUOUS IMPROVEMENT PROCESSES

Marc Severin discusses the H&T Excellence programme and how it has been expanded to include methods and training to help H&T Presspart identify environmental impact at a product group level and take co-ordinated action to reduce carbon emissions across the organisation.

EXPERT VIEW

Tom Oakley

“A CHILD IS NOT A SMALL ADULT”: CHALLENGES AND SOLUTIONS IN DEVELOPING DRUG DELIVERY DEVICES FOR CHILDREN

Tom Oakley and Heather Jameson consider the main differences in developing therapies and drug delivery devices for children and babies when compared with adults.

EXPERT VIEW

Carolina Dantas

THE POTENTIAL OF CONNECTIVITY AND MONITORING IN MESH NEBULISERS

Carolina Dantas and Ulf Krueger review the current connectivity and remote monitoring capabilities in mesh nebulisers – and their potential to impact patients’ healthcare journeys and the clinical development of inhaled therapies.

SUSTAINABILITY

Chris Baron

Aptar Pharma

NAVIGATING pMDI REFORMULATION 2.0

Chris Baron and William Ganley examine possible responses to the environmental impact of pressurised metered dose inhalers use and consider alternative inhaler types, with a focus on the strategies and support that can accelerate the development of the next generation of pMDIs.

PULMONARY

Dr Marie-Christine Klein

URSATEC

THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES

Marie-Christine Klein, Andreas Bilstein and Caroline Hoffmann discuss the underlying techniques involved in the use of metered pump-based soft mist devices and their application diversity.

PULMONARY

Dr Orest Lastow

Iconovo

NOVEL INDUSTRIAL-SCALE ELECTROSTATIC CHARGE ELIMINATION METHOD FOR INHALATION PRODUCTS

Orest Lastow describes a novel technique for removing the built-up charge from dry powder inhaler components, offering a potential solution to the issues caused by static charges in these devices, including decreased performance, altered powder properties and increased variability in delivered dose.

PULMONARY

Dr Mirjam Kobler

H&T Presspart

DEVELOPMENT APPROACH FOR A HIGH-PERFORMANCE CAPSULE-BASED DPI

Mirjam Kobler, Ameet Sule and Sunita Sule look at the factors affecting the performance of dry powder inhalers and discuss the company’s development of high-performance prototypes.

PULMONARY

Andy Cleall

3P Innovation

ARE YOU STRUGGLING TO PUT DIFFICULT POWDERS INTO CAPSULES?

Andy Cleall and Ben Smith discuss process optimisation and cutting-edge technology for powder filling, including how 3P’s R500 and R1000 robotic capsule fillers are pushing the boundaries of optimal filling and how its Fill2Weight technology enables increased filling accuracy and improved yields.

PULMONARY

Dr Rui Churro

Hovione

CAPSULE FILLING FOR DPIs – LINKING PROCESS SCALES THROUGH ADVANCED CHARACTERISATION AND QUALITY BY DESIGN

 Rui Churro, Carolina Lopes and João Pires discuss the value of rheological characterisation of powders to expedite and de-risk the scale-up of DPI capsule-filling processes.

PULMONARY

Dr Jasdip Koner

Aston Particle Technologies

ISOTHERMAL DRY PARTICLE COATING – BACK TO THE FUTURE?

Jasdip Koner, Abdul Ershad and David Wyatt introduce Aston Particle Technologies’ novel dry powder processing technology – isothermal dry particle coating (iDPC™) – explaining how it has the capacity to enhance and broaden the scope of what dry powder formulations can achieve in respiratory medicine.

EXPERT VIEW

Matt Jones

DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION

Matt Jones and Rob Veasey consider the process of matching the drug with the right delivery device and look at the importance of due diligence when “licensing in” technology.

EXPERT VIEW

Mark Parry

CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS

Mark Parry discusses the considerations that need to be made when switching from current pressurised metered dose inhaler propellants to new alternatives with lower global warming potential, including formulation, regulatory and analytical standpoints.

CONNECTIVITY

Edgar Hernan Cuevas Brun

HCmed Innovations

ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER

Edgar Hernan Cuevas Brun and Yuan-Ming Hsu consider patient adherence and the role HCmed Innovations’ AdheResp mesh nebuliser plays in monitoring adherence.

CONNECTIVITY

Dr Haykel Ben Jamaa

Sensirion

DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS

Haykel Ben Jamaa explores why modern society needs digital health and how it is organised and implemented, with a focus on sensing technologies empowering digital health technologies.

PULMONARY

Dr Orest Lastow

Iconovo

WHY ARE INHALATION DEVICES SO DIFFICULT TO DEVELOP?

Orest Lastow discusses the challenges of developing inhalation products and how best to keep costs down and prevent project delays.

EARLY INSIGHT

Dr Elijah Nazarzadeh

Nebu~Flow

CREATING A PLATFORM FOR NEBULISATION OF A WIDE RANGE OF DRUG TYPES AND FORMULATIONS

Elijah Nazarzadeh and John Pritchard introduce Nebu~Flow – a novel class of nebuliser technology that represents a major step in the ability to deliver drugs efficiently to the lungs. overcoming the limitations of current systems and unlocking the potential of the inhalation route, including for systemic delivery.

PULMONARY

Edgar Hernan Cuevas Brun

HCmed Innovations

A ROADMAP FOR DRUG-NEBULISER COMBINATION PRODUCT DEVELOPMENT

Edgar Hernan Cuevas Brun and Yuan-Ming Hsu lay out HCmed Innovations’ roadmap for the development of drug-nebuliser combination products.

SKIN

Dr Claire Authesserre

Eveon

AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST

Claire Authesserre and Florian Corne discuss the current challenges faced by the topical spray-based delivery of therapeutics and how EVEON’s Ad-Mist™ spray nozzle overcomes these challenges to harness the potential of this delivery route.

PULMONARY

Bryan Deacon

Celanese

GETTING A GRIP ON FRICTION – A CRUCIAL CONSIDERATION FOR INHALER DESIGN

Bryan Deacon discusses the importance of considering friction when developing a new inhaler design, providing an overview of some of the basic considerations friction raises, as well as highlighting how optimising friction early with the aid of a materials expert can reduce risk, lower cost and lead to a better product overall.

PULMONARY

Lynn Jordan

Proveris Scientific

EXPLORING NEW IN VITRO TESTS TO DEMONSTRATE BIOEQUIVALENCE IN INHALATION PRODUCTS

Proveris Scientific looks at recent advances in in vitro testing in inhalation products to demonstrate bioequivalence and discusses the company’s INVIDA platform that replicates human usage of the device.

EXPERT VIEW

Dr Yannick Baschung

EXPANDING THE DESIGN OF CHARACTERISATION STUDIES FOR ACCURATE HANDLING-ERROR ASSESSMENT

Yannick Baschung discusses the importance of a comprehensive and accurate assessment of patient handling errors when it comes to inhaled product development.

EXPERT VIEW

James Silk

THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION

James Silk discusses the importance of accounting for uncertainty when characterising the extractables profile of a medication, with particular reference to the ISO 10993 standard.

PULMONARY

Dr Salvatore Pillitteri

Granutools

POWDER CHARACTERISATION FOR DPI PERFORMANCE IN CAPSULE-BASED INHALERS

Salvatore Pillitteri, Aurélien Neveu and Sarah Zellnitz-Neugebauer discuss the analysis of three powder blends of salbutamol sulphate with distinct lactose grades, using tapped density and rotating drum methods.

PULMONARY

Dr Philippe Rogueda

Merxin

DELIVERING BIOLOGICS WITH SOFT MIST INHALERS – A MARKET POISED TO EXPAND

Philippe Rogueda discusses the inhalable biologics market, how the introduction of soft mist inhalers represents a significant opportunity for new and old therapeutics alike, and how the market is poised for a major expansion in therapeutic application, size and value.

INDUSTRIALISATION

Drew Jelgerhuis

Scherdel Medtec North America

ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE

Drew Jelgerhuis looks at how a design-for-excellence (DFX) systematic approach can help manufacturers achieve their objectives.

INDUSTRIALISATION

Rob Doorakkers

IGS GeboJagema

HIGH-PRECISION INJECTION MOULDS FOR INHALERS: CHALLENGES AND SOLUTIONS

Rob Doorakkers and Erwin van Huijksloot discuss the challenges and solutions of engineering and manufacturing high-precision injection moulds for inhalers.