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INDUSTRIALISATION
INJECTION
DUAL CHAMBER
FORMULATION
PFS
WEARABLES
ALL INJECTION
OCULAR
ORAL
RESPIRATORY
PULMONARY
NASAL
ALL RESPIRATORY
MORE
INTERVIEWS
EXPERT VIEWS
EARLY INSIGHTS
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OUR AUTHORS
THE MAGAZINE
EVENTS
ED CALENDAR
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OCULAR
OCULAR
EMPOWERING VISION FOR THE FUTURE: ADVANCED CONTAINMENT SOLUTIONS FOR OPHTHALMIC APPLICATIONS
Dr Linara Cornell, Dr Manali Potnis and Dr Krishnendu Khan review the current landscape and challenges associated with delivery systems for ophthalmic applications, and how West Pharmaceutical Services plays a critical role in this specialised industry by providing high quality prefilled syringe components and systems that meet the stringent requirements for these sight-saving therapies.
OCULAR
NOVELIA
®
: ENABLING THE NEXT GENERATION OF PRESERVATIVE-FREE MULTIDOSE OPHTHALMICS
Severine Duband and Natalia Zabala discuss the role of multidose preservative-free eyedroppers in the ophthalmic market, highlighting the advantages of Nemera’s Novelia
®
platform, including its non-return valve system, the sustainability of multidose delivery and the platform’s growing success within the Chinese market.
INDUSTRIALISATION
Paavo Sillanpää
UPM Adhesive Materials
CLOSING THE SAFETY GAP: WHY PHARMA-DEDICATED LABELS MATTER
Paavo Sillanpää discusses why pharma-dedicated labels matter for more challenging labelling applications as well as how to avoid potential label failure and brand risk.
OCULAR
Dr David Cottenden
TTP
THE RETINAL DELIVERY BOTTLENECK: WHY TODAY’S TOOLS WON’T SCALE
Dr David Cottenden and Benjamin Hatton examine the rapid shift towards cell and gene therapies in ophthalmology, indicated by current pharmaceutical pipelines, and reveal a potential delivery crisis – today’s surgical capacity cannot support what the pipeline demands. Considering this, they explore why a radical rethink of retinal delivery tools could unlock scalable access to the retina.
OCULAR
Dr Lorna Barron
Sanner Group
THE CHALLENGES IN DEVELOPING AND MANUFACTURING CUSTOM OPHTHALMIC INJECTOR DEVICES
Dr Lorna Barron sets out the standards that must be met for effective drug delivery to the eye, characterising both old and new delivery routes that may be used to address the unique challenges of ophthalmic disease.
OCULAR
Andreas Kalitzki
Bayer AG
SHL MEDICAL AND BAYER: A COLLABORATIVE APPROACH TO ADVANCING INTRAVITREAL PAEDIATRIC DOSING
Andreas Kalitzki, Samuel Wyler and Seda Aksel explain how Bayer and SHL Medical collaborative efforts are enhancing paediatric intravitreal injections through evidence-based dosing strategies and clinically validated therapies using SHL Medical’s Micro Dosing Device technology.
EXPERT VIEW
Gregg Draudt
INTRAVITREAL INJECTIONS – WHAT IS CAUSING PATIENTS TO DISCONTINUE THERAPY AND WHY IS IT SO HARD TO FIX?
Gregg Draudt considers the significant issue of treatment discontinuation in intravitreal therapies, digging into the root causes of poor adherence and what will be required to reverse this trend in a way that caters to the full range of stakeholders, who often have contradictory requirements.
EXPERT VIEW
Tina Rogers
WuXi AppTec
ADDRESSING OCULAR SAFETY CHALLENGES IN ADC DEVELOPMENT
Dr Tina Rogers discusses antibody-drug conjugates and their potential in direct targeting and treatment of cancers, going further to assess the risks of these treatments and how they can be mitigated.
EXPERT VIEW
Dr Max Chambers
REVEALING THE FRONTIER: DRUG DELIVERY CHALLENGES AND INNOVATIONS IN OCULAR GENE THERAPY
Dr Max Chambers discusses novel approaches for delivering ocular gene therapies, summarising the challenges and benefits of various delivery routes and exploring the devices used to successfully improve vision.
OCULAR
Dr Reza Abedian
Gerresheimer
A COMPREHENSIVE APPROACH TO ADDRESSING UNMET NEEDS IN INTRAVITREAL INJECTIONS
Dr Reza Abedian, Marie Stockton and Bernd Zeiss consider the complexities and clinical unmet needs of intravitreal injections and discuss how Gerresheimer’s syringe technology can help overcome these challenges.
OCULAR
Zoe Davidson
Nemera
GLAUCOMA IN VIEW: IMPROVING PATIENT ADHERENCE WITH MULTIDOSE EYEDROPPERS FOR PRESERVATIVE-FREE SOLUTIONS
Zoë Davidson considers the impact of glaucoma on global health and the challenges presented by the increasing prevalence of this disease in the ageing global population, discussing how Novelia®, Nemera’s multidose eyedropper for preservative-free formulations, is well-positioned to address many of the challenges presented by glaucoma treatments, from ease of use to sustainability.
EXPERT VIEW
Dr Joe Batley
GENE THERAPY IN OPHTHALMOLOGY: ADVANCES AND CHALLENGES
Joe Batley and Lorna Barron provide an overview of the latest cutting-edge ophthalmic delivery methods and discuss possible future developments.
OCULAR
Dr Anu Prabhathachandran
West Pharmaceutical Services
A NEW DELIVERY PLATFORM FOR SUPRACHOROIDAL ADMINISTRATION USING WEST’S ADVANCEABLE MICRONEEDLE DEVICE
Anu Prabhathachandran, Menachem Peretz and Manali Potnis discuss the growing need for more effective delivery of ophthalmic therapeutics to meet the needs of the ageing population, including how delivery into the suprachoroidal space may present an appealing alternative to intravitreal injection. They introduce West Pharmaceutical Service’ Suprachoroidal Advanceable Microneedle Device, which offers several advantages for overcoming the challenges with suprachoroidal space.
EXPERT VIEW
Binbin Tian
REVOLUTIONISING EYE CARE: THE POTENTIAL OF ANTISENSE OLIGONUCLEOTIDES
Binbin Tian discusses antisense oligonucleotides and considers their potential as treatments for genetic and multifactorial ophthalmic diseases previously considered untreatable. The article considers how these therapies function as treatments, their current state of development, challenges in their delivery and the evolving regulatory landscape
INJECTION
Thomas Isaac
Terumo Medical Care Solutions
INTRODUCING THE TERUMO INJECTION FILTER NEEDLE – A FIRST STEP OF THE INFINO™ DEVELOPMENT PROGRAMME
Thomas Isaac considers the issues associated with injection to highly sensitive areas, such as the vitreous body, and the potential to optimise needle design and features to address these issues, discussing the key features of Terumo’s Injection Filter Needle, indicated for hypodermic and intravitreal injections within this context.
PREFILLED SYRINGES
Dr Gautam Shetty
Congruence Medical Solutions
510(k) CLEARED, USER-FILLED MICRODOSING DEVICE FOR OPHTHALMIC AND OTHER APPLICATIONS
Gautam Shetty discusses unmet drug delivery needs in applications requiring accurate and precise microlitre-scale doses,going on to detail how the Congruence Medical’s recently cleared Microliter Dosing Syringe can bring the benefits of advanced syringe materials and performance to these applications.
OCULAR
Dr Andrea Allmendinger
ten23 health
ADDRESSING INTRAVITREAL PRODUCT MANUFACTURING AND DEVELOPMENT CHALLENGES
Andrea Allmendinger, Hanns-Christian Mahler and Philipp Behrendt discuss the challenges of filling very small volumes into syringes for intravitreal injections, and how ten23’s innovative filling technology can help combat the critical issue of air bubble formation.
INTERVIEW
Natalia Servol
Unither Pharmaceuticals
INTERVIEW: UNITHER PHARMACEUTICALS’ INNOVATIVE APPROACH TO OPHTHALMIC MANUFACTURING
Natalia Servol shares insights into Unither Pharmaceutical’s preservative-free multidose technology. With a focus on addressing patient needs and meeting industry demands, the company offers a distinctive approach to sterile manufacturing in the ophthalmic sector.
OCULAR
Rouven Kraus
Aero Pump
COMPARATIVE USABILITY STUDY OF MULTIDOSE PRESERVATIVE-FREE EYE DROP DEVICES
Rouven Kraus discusses the results of a study investigating dose accuracy and reproducibility, along with user preferences, for a variety of multidose preservative-free eye drop devices.
OCULAR
Zoe Davidson
Nemera
LISTENING TO THE PATIENT’S VOICE TO IMPROVE EYE CARE
Zoë Davidson discusses the benefits of collaborating with patients to improve eye care management.
EARLY INSIGHT
Dr Philippe Daull
Akrivision Technologies
ACCURATE DELIVERY & PRECISE DOSING OF EYE DROPS: WHAT IF WE CHANGE THE INSTILLATION PROCEDURE?
Philippe Daull and Pierre Roy discuss how changing the administration procedure for eye drops can improve the patient experience and eliminate health risks.
EXPERT VIEW
Tom Oakley
Sanner Group
DRUG DELIVERY TRENDS FOR 2024
Tom Oakley and Kamaal de Silva consider how keeping abreast of the latest trends can help the industry predict and prepare for the future and, commenting from Springboard's privileged position at the centre of many of the drug delivery sector’s most exciting developments, discuss the top trends to look out for in 2024.
SUSTAINABILITY
André Jansen
IGS GeboJagema
GREEN THINKING: HOW TO BECOME A MORE SUSTAINABLE ORGANISATION
André Jansen and Ron Cisliek describe how high-precision mould maker IGS GeboJagema is fostering a culture of “green thinking” and making sustainability a core part of its business.
EARLY INSIGHT
Dr Alex Tumlinson
ACQUIRING A LIQUID BIOPSY INCIDENTAL TO INTRAVITREAL INJECTION
Alexandre Tumlinson introduces Twenty/Twenty Therapeutics' VitreoDx injection system to address emerging trends in intravitreal therapeutics.
OCULAR
Yuki Takeuchi
Terumo Medical Care Solutions
OPTIMISING MICROLITRE DOSING: CASE STUDY WITH INTRAVITREAL INJECTION
Yuki Takeuchi and Richard Whelton discuss the challenges of delivering intravitreal injections and how the combination of Terumo’s PLAJEX™ prefillable syringes with Congruence’s Microlitre Dosing Syringe system is able to address them.
EXPERT VIEW
Dr Shiyan Chen
OVERCOMING CHALLENGES WHEN DEVELOPING OLIGONUCLEOTIDES FOR OPHTHALMIC DRUGS
Shiyan Chen and Binbin Tian discuss the use of oligonucleotides for ophthalmic applications, including their potential uses, advantages, challenges and difficulties when it comes to pharmacokinetic and drug metabolism studies.
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