Industrialising Drug Delivery110

Issue No #110 Aug 2020 August 28th, 2020

Inside the magazine

INNOVATION AND AUTOMATION IN TOPICAL FORMULATION DEVELOPMENT

INDUSTRIALISATION

Prof Marc Brown

INNOVATION AND AUTOMATION IN TOPICAL FORMULATION DEVELOPMENT

Marc Brown, Jon Lenn and Charles Evans discuss the challenges faced by the pharmaceutical industry during the development of topical delivery formulations, and how MedPharm’s performance testing models help identify and mitigate risks during the process.

FROM FORMULATION TO MANUFACTURING: LIPID NANOPARTICLE mRNA VACCINES, GENE THERAPIES & OTHER NANOMEDICINES

INDUSTRIALISATION

FROM FORMULATION TO MANUFACTURING: LIPID NANOPARTICLE mRNA VACCINES, GENE THERAPIES & OTHER NANOMEDICINES

Stephen Allan reviews the history and formulation advantages of lipid nanoparticles (LNPs) and addresses factors that should be considered by pharmaceutical companies during the CDMO selection process to help reduce regulatory risk, improve product performance and accelerate speed to market.

INTERVIEW WITH AARON MANN, CHIEF EXECUTIVE OFFICER, KINDEVA

INTERVIEW WITH AARON MANN, CHIEF EXECUTIVE OFFICER, KINDEVA

In this exclusive interview with ONdrugDelivery, Aaron Mann discusses how Kindeva is positioned to move forward as a major CDMO specialising in inhalation and transdermal dosage forms, having been formed from 3M’s drug delivery in May 2020. We also cover the impact of Covid-19, environmental sustainability, and current challenges faced by the pharmaceutical industry.

ROUNDTABLE: JEREMY DRUMMOND, MEDPHARM; STEPHEN RODE, LONZA; AND TORKEL GREN, RECIPHARM

Dr Jeremy Drummond

ROUNDTABLE: JEREMY DRUMMOND, MEDPHARM; STEPHEN RODE, LONZA; AND TORKEL GREN, RECIPHARM

In this roundtable discussion, Jeremy Drummond, Stephen Rode and Torkel Gren discuss trends with different drug dosage forms for different routes of administration, the rise of patient centricity including the shift from the blockbuster model to more tailored products.

ADVANCED CAPSULE TECHNOLOGIES: DRY POWDER INHALERS TO TARGET DISEASE

Frédérique Bordes-Picard

ADVANCED CAPSULE TECHNOLOGIES: DRY POWDER INHALERS TO TARGET DISEASE

Frédérique Bordes-Picard and Julien Lamps discuss the value of capsule-based dry powder inhalers in the modern respiratory market, the factors driving development in this area and considerations for matching a capsule to a device and formulation.

CUSTOMISING PLATFORM DEVICES: CHALLENGES & CONSIDERATIONS

INDUSTRIALISATION

CUSTOMISING PLATFORM DEVICES: CHALLENGES & CONSIDERATIONS

How do you choose the best delivery system for your drug? Doug Boyd explores the pros and cons of a cost-effective, off-the-shelf platform versus a custom drug delivery device, and discusses the challenges and considerations of customising an existing platform device.

MEETING QUALITY DEMANDS THROUGH INTEGRATED PRODUCTS & SERVICES

INDUSTRIALISATION

Lars Keinicke Hansen

Stevanato Group

MEETING QUALITY DEMANDS THROUGH INTEGRATED PRODUCTS & SERVICES

Lars Keinicke Hansen; Chiara Mussoi and Odra Pinato describe how the streamlining of processes and harmonisation of products and services can better serve pharmaceutical companies. A case study highlights how a unique combination of expertise in automation and glass primary packaging benefited pharma giant Merck Serono in a recent project.

INTEGRATING DESIGN AND INDUSTRIALISATION TO OPTIMISE COST, QUALITY & TIME

INDUSTRIALISATION

INTEGRATING DESIGN AND INDUSTRIALISATION TO OPTIMISE COST, QUALITY & TIME

Pete Evans and Meredith Canty explore how integrating design and industrialisation teams can optimise the cost, quality and time of developing a novel drug delivery system.

MEETING DEMAND BY BRINGING MANUFACTURING IN-HOUSE

INDUSTRIALISATION

MEETING DEMAND BY BRINGING MANUFACTURING IN-HOUSE

Bentsi Algazi and Anna Kalika-Rodin discuss the process of developing and implementing in-house production facilities at Sorrel Medical, including cleanroom facilities. The authors discuss the regulatory requirements involved, practical considerations of the design and construction, and the benefits the establishment of in-house facilities confers to Sorrel and its pharmaceutical partners.

APPLICATIONS OF DEEP LEARNING IN MEDICAL DEVICE MANUFACTURING

INDUSTRIALISATION

Frederick Gertz

APPLICATIONS OF DEEP LEARNING IN MEDICAL DEVICE MANUFACTURING

Frederick Gertz and Gilbert Fluetsch look at how deep learning can be leveraged in a medical device manufacturing environment.

THE FUTURE OF SMART FILL-AND-FINISH

INDUSTRIALISATION

THE FUTURE OF SMART FILL-AND-FINISH

Diana Löber discusses new developments in digitised pharmaceutical manufacturing and the role SCHOTT’s Smart Containers can play in traceability along the entire value chain.

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