Latest Issue

Prefilled Syringes & Injection Devices166

Issue No #166 Oct 2024 October 4th, 2024

Inside the magazine

SUBCUTANEOUS DRUG DELIVERY: ADAPTING TO HIGH-VISCOSITY, LARGE-VOLUME DEMANDS

Thomas Fontanellaz

SUBCUTANEOUS DRUG DELIVERY: ADAPTING TO HIGH-VISCOSITY, LARGE-VOLUME DEMANDS

Thomas Fontanellaz, Reto Jost and Andreas Schneider discuss how Ypsomed is addressing the growing need for subcutaneous injections that accommodate higher volumes and viscosities, with innovative self-injection devices designed to enhance patient comfort and adherence.

STREAMLINING THE TESTING PROCESS FOR AUTOINJECTOR DEVICES

Landon Goldfarb

STREAMLINING THE TESTING PROCESS FOR AUTOINJECTOR DEVICES

Landon Goldfarb highlights the challenges of autoinjector testing and the importance of drawing on the experience of customers when it comes to drug delivery device innovation.

INTERVIEW with Scott Ariagno, EdgeOne Medical

EdgeOne Medical

INTERVIEW with Scott Ariagno, EdgeOne Medical

Scott Ariagno talks exclusively with ONdrugDelivery's Guy Furness about the role that contract development organisations play in the drug delivery industry ecosystem and how independent expertise can enable companies like EdgeOne Medical to troubleshoot and accelerate product development.

SHL MEDICAL’S ELEXY™: REDEFINING POSSIBILITIES

Vince Masciopinto

SHL MEDICAL’S ELEXY™: REDEFINING POSSIBILITIES

Vince Masciopinto introduces Elexy™ SHL's new reusable electromechanical autoinjector, highlighting the various advantages that the device platform offers at preclinical, clinical and commercial stages due to its ability to deliver a variety of injection profiles from different primary containers without requiring any mechanical reconfiguration of the device.

SPRINGS: THE KEY TO ADVANCED AUTOINJECTOR AND PEN INJECTOR PERFORMANCE

SPRINGS: THE KEY TO ADVANCED AUTOINJECTOR AND PEN INJECTOR PERFORMANCE

Emilie Aranda and Fernando González discuss the crucial role of spring mechanisms and other metal parts in autoinjectors and pen injectors.

THE RISE OF THE NEXT-GEN CDMO: STRATEGIES FOR REDUCING RISK AND TIME TO MARKET

INDUSTRIALISATION

THE RISE OF THE NEXT-GEN CDMO: STRATEGIES FOR REDUCING RISK AND TIME TO MARKET

Alex Vasiev discusses how next-generation CDMOs can ensure the successful commercialisation of new combination products by mitigating development risks, accelerating time to market and helping to avoid costly changes late in the development process.

FLUROTEC<sup>®</sup> PREFILLABLE SYRINGE PLUNGERS: A SOLUTION FOR LOW-TEMPERATURE STORAGE

Christa Janssen-Otten

West Pharmaceutical Services

FLUROTEC^® PREFILLABLE SYRINGE PLUNGERS: A SOLUTION FOR LOW-TEMPERATURE STORAGE

Christa Jansen-Otten discusses how West Pharmaceutical Services' FluroTec plungers for prefilled syringe solutions can cope with cold storage conditions to extend drug shelf life and preserve integrity.

NOLATO’S VIRTUAL FACTORY

INDUSTRIALISATION

Patrik Ingvarsson

NOLATO’S VIRTUAL FACTORY

Patrik Ingvarsson, showcases the Nolato's virtual factory, highlighting the advantages of virtual tools for product development in the medical device industry.

OXYCAPT VIAL’S CONTAINER CLOSURE INTEGRITY WITH DRY ICE AFTER FREEZING AND THAWING

Hiroki Hasegawa

Mitsubishi Gas Chemical

OXYCAPT VIAL’S CONTAINER CLOSURE INTEGRITY WITH DRY ICE AFTER FREEZING AND THAWING

Hiroki Hasegawa and Tomohiro Suzuki review the benefits of MGC’s multilayer plastic OXYCAPT™ vials and discuss a recent experiment comparing the ability of OXYCAPT and COP vials to resist permeation by CO₂ upon thawing after being stored below -60°C.

ROUNDTABLE: DISCUSSION ON ANTI-OBESITY TREATMENTS

ROUNDTABLE: DISCUSSION ON ANTI-OBESITY TREATMENTS

Stephen M Perry, Mathias Romacker and Andreas Schneider tackle the subject of GLP-1s and related obesity-targeted injectable therapeutics and the enormous impact they are having and are expected still to have on drug delivery and the wider pharmaceutical sector.

COMPANY SHOWCASE: PCI PHARMA SERVICES

INDUSTRIALISATION

PCI Pharma Services

COMPANY SHOWCASE: PCI PHARMA SERVICES

As a trusted partner, PCI offers expertise and solutions in sterile fill-finish and specialist final assembly and packaging of advanced drug delivery and drug-device combination products, including seamless end-to-end injectable solutions.

FUTURE TRENDS FOR NOVEL INJECTABLE DRUG DELIVERY

Chris Hurlstone

FUTURE TRENDS FOR NOVEL INJECTABLE DRUG DELIVERY

Chris Hurlstone looks at the increasing demand for novel injectable devices and summarises the areas we can expect to see significant development activities in injectable technologies.

A NEW DIMENSION: BALANCING BIOLOGIC LIMITATIONS AND PATIENT PERCEPTIONS FOR AN ENHANCED INJECTION EXPERIENCE

Enrico Barichello

Stevanato Group

A NEW DIMENSION: BALANCING BIOLOGIC LIMITATIONS AND PATIENT PERCEPTIONS FOR AN ENHANCED INJECTION EXPERIENCE

Enrico Barichello and Carlo Valbonesi discuss the need to harmonise the formulation parameters with patient convenience and comfort for injections, and demonstrate how Stevanato Group has solved this issue through innovation in injector components.

THE PERFORMANCE OF EUROJECT – A BFS-BASED INJECTION DEVICE

PREFILLED SYRINGES

Nourhène Esseghir

Unither Pharmaceuticals

THE PERFORMANCE OF EUROJECT – A BFS-BASED INJECTION DEVICE

Nourhène Esseghir, Alexandre Fontayne and Laury Livemont discuss the performance and benefits of Unither's Euroject^® injection system.

ALTAVISC: EXPANDING THE DELIVERY WINDOW FOR HIGH-VISCOSITY & HIGH-VOLUME DRUGS

Nelson Quintana

ALTAVISC: EXPANDING THE DELIVERY WINDOW FOR HIGH-VISCOSITY & HIGH-VOLUME DRUGS

Nelson Quintana discusses how Altaviz's AltaVISC delivery technology reaps the benefits of gas-powered drive systems over traditional spring-based systems for autoinjectors to offer a highly flexible platform technology for drug developers, allowing them to optimise their formulations within a wider range of delivery device specifications.

BEYOND PROBABILITY: CHOOSING DETERMINISTIC METHODS FOR RELIABLE CONTAINER CLOSURE INTEGRITY TESTING

Antonio Scatena

Gateway Analytical

BEYOND PROBABILITY: CHOOSING DETERMINISTIC METHODS FOR RELIABLE CONTAINER CLOSURE INTEGRITY TESTING

Antonio Scatena answers some of the most common questions regarding the container closure integrity testing methods used to detect leaks and defects – and discusses how the industry can meet the updated expectations set by regulatory bodies.

COMPREHENSIVE TESTING PROVES DESIGN CONCEPT OF NOVEL AUTOINJECTOR PLATFORM

Dr Farid Seddighi

COMPREHENSIVE TESTING PROVES DESIGN CONCEPT OF NOVEL AUTOINJECTOR PLATFORM

Farid Seddighi, Sigrid Saaler-Reinhardt and Daniel Primavessy discuss the critical importance of testing at an early stage of medical device development, presenting an overview of the results that confirm the technical performance and usability of the novel Gx Inbeneo^® autoinjector.

DEFINING HIGH-VISCOSITY, LARGE-VOLUME DRUG DELIVERY SYSTEMS

DEFINING HIGH-VISCOSITY, LARGE-VOLUME DRUG DELIVERY SYSTEMS

Kyle Toole, Blair Hutton and James McLusky discuss the value that mathematical modelling can provide in the early stages of injectable drug delivery device development, especially when coupled with appropriate empirical testing in a laboratory setting.

IT’S TIME TO CONSIDER INTRADERMAL DELIVERY

Dr Nicky Bertollo

IT’S TIME TO CONSIDER INTRADERMAL DELIVERY

Nicky Bertollo, Adam Rock and Saidhbh O’Callaghan discuss the progress Pharma Latch’s intradermal drug delivery platform is making towards realising the potential the intradermal route offers to drug developers, especially for vaccines.

NAVIGATING THE AI REVOLUTION IN THE MEDICAL DEVICES SECTOR: BETWEEN INNOVATION AND REGULATION

NAVIGATING THE AI REVOLUTION IN THE MEDICAL DEVICES SECTOR: BETWEEN INNOVATION AND REGULATION

Timothy Bubb discusses the potential impact of artificial intelligence and machine learning on the healthcare and drug delivery industries, with an overview of the differing regulatory approaches taken by the EU, US FDA and UK MHRA towards this novel area of digital health.

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