Citation: “Product Profile: DF30 with COCe”. ONdrugDelivery Magazine, Issue 66 (Apr 2016), p 29.

Aptar Pharma’s new DF30 metering valve version incorporates a cyclic olefin copolymer (COC) neck gasket to enhance its performance further. It is the result of continuous improvement to today’s world-leading DF30 technology platform.

Aptar Pharma’s DF30 metering valve technology platform (Figure 1) has been the industry gold standard for more than 20 years and we are constantly striving to optimise our DF30 product offering. COC is a well-known and characterised material used for injectable drug containers. COCe is a specific version of COC that has unique elastomeric properties while being ultra-clean and inert.

Figure 1: DF30 metering valve (Image Courtesy of Aptar Pharma)

The new version of DF30 – that incorporates a neck gasket which is manufactured with COCe – offers several key benefits:

  • Step change improvement as a barrier to leakage
  • Ultra low extractible level
  • Compatibility across a wider range of drug formulations, including ethanol-containing formulations
  • Suitable for all pMDI filling technologies
  • Robust design for accurate and consistent performance.

Each year, Aptar Pharma manufactures and supplies several hundred million metering valves which are used by the world’s leaders in the pharma industry.

For more information on DF30 Technology Platform, please visit: