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TRANSDERMAL

THE FOURTH INDUSTRIAL REVOLUTION – ROBOTICS AND THE LABORATORY
INDUSTRIALISATION
Prof Marc Brown
MedPharm
THE FOURTH INDUSTRIAL REVOLUTION – ROBOTICS AND THE LABORATORY
Marc Brown and Jon Lenn look at MedPharm’s implementation of automated robotic systems in enhancing workflow and the company’s plans for the future implementation of robotics in formulation development.
PRODUCT SHOWCASE: Logan Instruments’ Transdermal Testing Portfolio
TRANSDERMAL
Jensen Lee
PRODUCT SHOWCASE: Logan Instruments’ Transdermal Testing Portfolio
Logan Instruments, a provider of laboratory instrumentation to the global pharmaceutical and cosmetics industries, with a focus on physical, dissolution and transdermal testing systems, showcases its pioneering transdermal testing system offering.
MEDICSEN: NEEDLE-FREE SMARTPATCH FOR PAINLESS DRUG DELIVERY
EARLY INSIGHT
Dr Eduardo Jorgensen
MEDICSEN: NEEDLE-FREE SMARTPATCH FOR PAINLESS DRUG DELIVERY
Eduardo W Jørgensen, Juan César de Mercado and José Carlos Montesinos describe the Smartpatch, a novel technology for subcutaneous delivery of drugs via a comfortable, pain-free patch using sonophoresis, based on Medicsen’s patented miniaturised ultrasound technology.
INTERVIEW WITH AARON MANN, CHIEF EXECUTIVE OFFICER, KINDEVA
INTERVIEW
Aaron Mann
INTERVIEW WITH AARON MANN, CHIEF EXECUTIVE OFFICER, KINDEVA
In this exclusive interview with ONdrugDelivery, Aaron Mann discusses how Kindeva is positioned to move forward as a major CDMO specialising in inhalation and transdermal dosage forms, having been formed from 3M’s drug delivery in May 2020. We also cover the impact of Covid-19, environmental sustainability, and current challenges faced by the pharmaceutical industry.
SYNERGISING EXCIPIENTS TO BOOST SKIN DELIVERY
SKIN
Cécile Morin
SYNERGISING EXCIPIENTS TO BOOST SKIN DELIVERY
Cécile Morin and Delphine Marchaud discuss combining polar and apolar excipients in topical formulations in order produce synergies that maximise the performance of the drug.
SILICA NANO-SOLUTIONS FOR SKIN DELIVERY
SKIN
Dr Aparajita Khatri
SILICA NANO-SOLUTIONS FOR SKIN DELIVERY
Aparajita Khatri and Christophe A Barbé outline the growth of the dermal delivery market, as well as the challenges it faces. The authors go on to detail a nanocomposite lidocaine patch.
COST-EFFECTIVE APPROACHES FOR SUCCESSFUL GENERIC DERMAL DRUG PRODUCT AUTHORISATIONS
SKIN
Prof Marc Brown
MedPharm
COST-EFFECTIVE APPROACHES FOR SUCCESSFUL GENERIC DERMAL DRUG PRODUCT AUTHORISATIONS
Marc Brown, Jon Lenn and Jeremy Dummond discuss various methods and advantages of in vitro bioequivalence studies for topical skin application, and how MedPharm’s unique technologies and experience can be invaluable in the effective development of generics in this field.
QUALITY BY DESIGN IN TDS DEVELOPMENT: BENEFIT OR BUREAUCRATIC BURDEN?
EXPERT VIEW
Petra Botzem
QUALITY BY DESIGN IN TDS DEVELOPMENT: BENEFIT OR BUREAUCRATIC BURDEN?
Petra Botzem and Thomas Hille discuss the Quality-by-Design approach to the development of transdermal drug delivery systems as laid out in ICH guideline Q8.
THE CRITICALITY OF ADHESIVE SELECTION FOR OPTIMAL TRANSDERMAL DRUG DELIVERY SYSTEMS
TRANSDERMAL
Megan Greth
THE CRITICALITY OF ADHESIVE SELECTION FOR OPTIMAL TRANSDERMAL DRUG DELIVERY SYSTEMS
Megan Greth and Gozde Karabiyik discuss why selecting the right adhesive for body-worn drug delivery systems – be they transdermal patches or wearable injection devices or pumps – is critical for a successful outcome.
OPTIMISING <i>IN VITRO</i> TESTING FOR TRANSDERMAL AND TOPICAL DRUG PRODUCTS
TRANSDERMAL
Tony Copley
Copley Scientific
OPTIMISING IN VITRO TESTING FOR TRANSDERMAL AND TOPICAL DRUG PRODUCTS
Tony Copley examines the regulatory framework for transdermal and topical products and popular, effective and cost-efficient in vitro testing techniques for quantifying their release characteristics.
NEW RESEARCH TOOLS FOR TOPICAL & TRANSDERMAL DEVELOPMENT
TRANSDERMAL
Prof Marc Brown
MedPharm
NEW RESEARCH TOOLS FOR TOPICAL & TRANSDERMAL DEVELOPMENT
Marc Brown, Rob Turner and James Gibbons provide a view on the current topical and transdermal market, elaborate on some of the common approaches to product development in this area, and reveal the company’s newest model, the MedFlux-HT™ system.
MICROBRISTLE APPLICATOR (MBA™) SYSTEMS FOR TOPICAL AND TRANSDERMAL DRUG APPLICATION
TRANSDERMAL
Pierre Michelet
MICROBRISTLE APPLICATOR (MBA™) SYSTEMS FOR TOPICAL AND TRANSDERMAL DRUG APPLICATION
Pierre Michelet, Karl Hartstock-Martin, and Moritz Beyhl present the innovative technology of microbristle applicators (MBA™) for a more precise and hygienic application within topical and transdermal treatment. MBA™ comprises a platform of moulded, pure plastic applicators with very fine bristles to apply liquid and semi-liquid formulations.
MEETING EVOLVING BIOLOGICS & SMALL MOLECULES NEEDS
MICRONEEDLES
Dr Lisa A Dick
MEETING EVOLVING BIOLOGICS & SMALL MOLECULES NEEDS
Lisa A Dick provides a run-down of the concept, design and development of the company’s microneedle drug delivery platform, both hollow and solid needle arrays, including recent clinical trials of the hollow-needle device.
AQUARMED™: TRANSDERMAL DELIVERY USING NOVEL COMPONENTS
TRANSDERMAL
Prof Marc Brown
MedPharm
AQUARMED™: TRANSDERMAL DELIVERY USING NOVEL COMPONENTS
Marc Brown, Adrian Williams and James Gibbons explain how the company has developed AquaRMed and describe the potential benefits it could offer patients and companies alike.
Q&A: SUCCESSFUL MASS PRODUCTION OF AN INNOVATIVE DRUG DELIVERY TECHNOLOGY
MICRONEEDLES
Dr Jung Dong Kim
Q&A: SUCCESSFUL MASS PRODUCTION OF AN INNOVATIVE DRUG DELIVERY TECHNOLOGY
Jung Dong Kim answers questions about the company, its capabilities, and the mass production of an innovative dissolving microstructure drug delivery technology.
HIGHLY CUSTOMISABLE HOLLOW POLYMER MICRONEEDLE SOLUTIONS
MICRONEEDLES
Dr Marion Sausse Lhernould
HIGHLY CUSTOMISABLE HOLLOW POLYMER MICRONEEDLE SOLUTIONS
Marion Sausse Lhernould, Serge Tailler, Michel Deleers and Alain Delchambre present a hollow microneedle delivery device manufactured using a novel proprietary process.
NOVEL TRANSDERMAL DELIVERY SYSTEMS FOR TREATMENT OF DIABETES
TRANSDERMAL
Dr Alan Smith
NOVEL TRANSDERMAL DELIVERY SYSTEMS FOR TREATMENT OF DIABETES
Alan Smith outlines the stages of Type 2 diabetes treatment, progressing to extenatide and insulin injections, and makes the case, using clinical data, for the transdermal route as a viable alternative to injections.
TRANSDERMAL DELIVERY DEVICE DESIGN
EXPERT VIEW
Bruce K Redding
TRANSDERMAL DELIVERY DEVICE DESIGN
Bruce K Redding Jnr gives an overview of the different types of transdermal patch design, as well as the various methods of getting through the skin.
TRANSDERMAL DELIVERY AS A NEW SOURCE FOR BIOPHARMA INNOVATION
EXPERT VIEW
Dr Kevin Pang
TRANSDERMAL DELIVERY AS A NEW SOURCE FOR BIOPHARMA INNOVATION
Kevin Pang discusses the potential of transdermal delivery, how it has thus far failed to live up to it and how a combination of formulation and electronic advancements mean it could soon be realised.
DESIGNING AN ULTRASOUNDENABLED PATCH FOR INSULIN
TRANSDERMAL
Bruce K Redding
DESIGNING AN ULTRASOUNDENABLED PATCH FOR INSULIN
Bruce K Redding Jr tells the story of the design and development of the U-Strip™ Insulin Transdermal Delivery System.
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