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INJECTION
DUAL CHAMBER
FORMULATION
PFS
WEARABLES
ALL INJECTION
OCULAR
ORAL
RESPIRATORY
PULMONARY
NASAL
ALL RESPIRATORY
SKIN
SUSTAINABILITY
MORE
INTERVIEWS
EXPERT VIEWS
EARLY INSIGHTS
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OUR AUTHORS
THE MAGAZINE
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ED CALENDAR
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DUAL CHAMBER
DUAL CHAMBER
Enrico Barichello
Stevanato Group
TWO INTO ONE: SOLVING COMPLEX DRUG DELIVERY PROBLEMS WITH DUAL-CHAMBER CONTAINMENT SOLUTIONS
Enrico Barichello and Valerio Ravazzolo describe how dual-chamber solutions ensure isolation, integrity and safety for managing lyophilised and liquid drugs. With innovative and customisable designs, these technologies improve drug delivery, reduce contamination risks and simplify complex therapies, addressing the evolving needs of both pharmaceutical industry and patients.
DUAL CHAMBER
Dr Nina Fetz
SHL Medical
ADVANCING LYOPHILISED DRUG DELIVERY WITH REUNITE™: RECONSTITUTION MADE SIMPLE
Dr Nina Fetz introduces SHL Medical's Reunite
®
, the first and only commercialised dual-chamber cartridge, three-step autoinjector featuring the company’s Needle Isolation Technology. With automated reconstitution, Reunite enables reliable self-injection of lyophilised formulations, supporting home-based care models.
DUAL CHAMBER
Dr Brent Buchine
Windgap Medical
BEYOND THE BARREL: A DUAL-CARTRIDGE IMPROVEMENT TO TRADITIONAL DUAL-CHAMBER DEVICES
Dr Brent Buchine explores how Windgap Medical’s devices transform dual-chamber systems with a modular, scalable and remarkably simple approach to reconstitution and complex drug delivery.
EXPERT VIEW
Edward Trappler
FROM HOSPITAL TO HOME HEALTHCARE: ADVANCES IN LYOPHILISED PRODUCT DELIVERY
Edward Trappler, Denise Miller and Michael Thomas discuss the challenges for lyophilised products and consider the role of dual-chamber devices in simplifying reconstitution, particularly for at-home healthcare products, and go on to look at how future advances in delivery devices are providing safe solutions for self-administration while improving patient adherence.
EXPERT VIEW
Kristien De Clercq
POWDER TO THE PEOPLE: ACCELERATING ACCESS TO LYOPHILISED THERAPIES
Kristien De Clercq and Dr Alex Vasiev discuss the challenges and recent advances in drying and reconstitution technologies, as well as how, while dual-chamber primary packaging offers a potential solution for simplifying reconstitution, it remains underused due to usability concerns and a prevailing industry preference for vial-based lyophilisation over alternative drying methods such as spray drying and powder filling.
DUAL CHAMBER
Dr Markus Neumeier
Vetter Pharma
ADVANCING LYOPHILISED DRUG DEVELOPMENT IN DUAL-CHAMBER SYSTEMS
Dr Markus Neumeier details the lyophilisation process and the range of elements that need to be examined for a dual-chamber system undergoing freeze-drying, while also laying out the quality control processes to conduct when transitioning from the laboratory to industrial-scale operations.
EARLY INSIGHT
Eric Sugalski
Ampulis
Early Insight: RETHINKING DUAL-CHAMBER SYRINGES: A LATERAL APPROACH TO FASTER, SAFER RECONSTITUTION
Eric Sugalski examines the limitations of current concentric dual-chamber syringe designs and explores a novel, lateral-chamber approach from Ampulis – the Ampulis Reconstitution Syringe.
EARLY INSIGHT
Gareth Pearce
Pacifi Ltd
Early Insight: DuoVIAL
®
– PROTECT, MIX AND DELIVER
Gareth Pearce introduces Pacifi's DuoVIAL
®
primary packaging technology for topical lyophilised formulations – a minimalist dual-chamber drug delivery system that enables safer, easier and more cost-effective reconstitution, while retaining the proven materials, formats and filling processes well established in the pharmaceutical sector.
EXPERT VIEW
María FM Balson
DELIVERING COMPLEXITY: DEVICE CONSIDERATIONS FOR TWO-COMPONENT INJECTABLE FORMULATIONS
María FM Balson weighs up strengths and limitations when developing devices for lyophilised injectables, exploring their growing demand and the impacts of formulation, device type and design on the feasibility for bringing a device to market to deliver these essential therapies.
INTERVIEW
Mathias Romacker
Kymanox
Interview: PDA Miniverse and Trends in Injectable Drug Delivery
In this exclusive interview, Mathias Romacker and Evan Edwards talk with ONdrugDelivery’s Guy Furness about the upcoming inaugural PDA Miniverse conference in Indianapolis, and the topics and trends currently being felt across the injectable drug delivery industry.
INJECTION
Vetter Pharma
COMPANY SHOWCASE: VETTER PHARMA
Vetter is a CDMO that offers services for pharma and biotech firms of all sizes and locations and holds numerous patents, including technologies for protection against tampering and counterfeiting. Its expertise ranges from lyophilisation (freeze-drying) to siliconisation and more.
DUAL CHAMBER
Dr Brent Buchine
Windgap Medical
DESIGNING FOR SUCCESS: CHOOSING THE RIGHT PRIMARY DRUG CONTAINER FOR PREFILLED DELIVERY DEVICES
Brent Buchine and Jason Durkin reflect on the motivations and lessons from Windgap’s journey to design patient-centric, prefilled autoinjectors around custom and standard primary drug containers.
EARLY INSIGHT
Dr Phil Green
Capa Valve
CAPA VALVE’S PATENTED TECHNOLOGY TRANSFORMS ANY SYRINGE INTO A DCD
Phil Green, Dale Charlton and Kevin Abbott introduce Capa Valve’s novel valve system for converting standard syringes into prefilled dual-chamber devices, capable of simplifying and improving the delivery of liquid-liquid and liquid-powder drug products, including reconstitution of lyophilised powders.
INTERVIEW
Dr Doug Bryans
Bryllan
INTERVIEW: DOUG BRYANS, BRYLLAN & JOHN MERHIGE, CREDENCE
Douglas Bryans and John Merhige discuss the changing needs of drug developers around novel dual-chamber and ready-to-use drug delivery devices, capacity and the delivery of complete solutions from CDMOs and device developers, anchored around the recently announced partnership between Credence MedSystems and Bryllan to provide these critical services.
DUAL CHAMBER
Dr Brent Buchine
Windgap Medical
IN THE THICK OF IT: ACCELERATING THE MIXING AND DELIVERY OF HIGH-VISCOSITY INJECTABLES
Brent Buchine, Miriam Silton, Jameson Woods and Andrew Ryan explore how the combination of gas power and a side-by-side cartridge configuration increases the working viscosity range for the mixing and delivery of complex injectable formulations.
WEARABLES
Dr Mehul Desai
Enable Injections
A NEW FRONTIER: SELF-ADMINISTRATION OF LYOPHILISED, LARGE-VOLUME SUBCUTANEOUS BIOLOGICS
Mehul Desai and Daniel Waites discuss the pros and cons of lyophilisation for biologic injectable drugs, and how Enable Injections’ enFuse device can provide an answer to the challenges of self-injection of large-volume and lyophilised biologics.
INJECTION
Dr Brent Buchine
Windgap Medical
PATIENT-CENTRIC DESIGN CAN BE A FASTER PATH TO MARKET
Brent Buchine considers a faster path to market for automated and easy-to-use reconstitution devices through simplification of the delivery systems.
DUAL CHAMBER
Dr Fred Metzmann
Haselmeier
ADVANCED DELIVERY DEVICE TECHNOLOGY TO SIMPLIFY THE RECONSTITUTION OF LYOPHILISED DRUGS
Fred Metzmann and Chris Muenzer present Haselmeier’s innovative approach to the development of reconstitution devices that allow easy and convenient administration of freeze-dried biologics.
DUAL CHAMBER
Dr Brent Buchine
Windgap Medical
IT’S TIME TO LEVEL UP LYO – INTRODUCING A SWIFT SHIFT IN DUAL-CHAMBER AUTOINJECTOR TECHNOLOGY
Brent Buchine discusses the need for automated, easy-to-use reconstitution devices, especially in lyophilised medications, and introduces Windgap Medical’s technology platforms, which rise to the challenge.
PREFILLED SYRINGES
Michelle Deutsch
SCHOTT Pharma
TAKING INTEGRATED NEEDLE SAFETY SYSTEMS FOR PREFILLED SYRINGES TO THE NEXT LEVEL
Michelle Deutsch and John Merhige discuss the needle safety requirements of prefilled syringes and consider how SCHOTT TOPPAC
®
and syriQ
®
PFS with Credence Companion
®
technology combine to meet these challenges, while ensuring the device meets sustainability demands.
INJECTION
Dr Dave Seaward
3P Innovation
DRIVERS FOR CHANGE IN ASEPTIC AUTOMATION
Dave Seaward and David Phasey discuss the factors that have led to recent growth in aseptic automation within the pharmaceutical industry.
FORMULATION
Caroline Zakrzewski
Cambridge Design Partnership
FORMULATION & DEVICE DEVELOPMENT: A SYMBIOTIC RELATIONSHIP
Caroline Zakrzewski considers the interaction between formulation and device development and the challenges that drive innovation in the field. Her work frequently sits in the overlap between formulation and device development, navigating the interwoven steps that lead to the sweet spot, where formulation and a device work in tandem, providing safe and effective delivery of the drug.
INTERVIEW
John Merhige
Credence MedSystems
JOHN A MERHIGE, CREDENCE MEDSYSTEMS
John Merhige discusses Credence’s Companion Safety Syringe System, new advances in the product development pipeline, customer/market driven feedback from user studies and exciting developments planned for 2018 that will take the company on to the next major phase in its growth.
PREFILLED SYRINGES
Dr Menachem Zucker
A REVIEW OF REUSABLE AUTO-INJECTORS FOR BIOLOGICAL & BIOSIMILAR DRUGS
From the perspective of the growing biologics and emerging biosimilars markets, Menachem Zucker showcases E3D – Elcam Drug Delivery Devices' mechanical and electronic auto-injector platforms, both of which are reusable devices with disposable cassettes.
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