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INJECTION

MORE THAN THE SUM OF ITS PARTS: HOW SUPPLIER COLLABORATION DRIVES SUCCESSFUL COMBINATION PRODUCTS
INJECTION
Bernd Zeiss
Gerresheimer
MORE THAN THE SUM OF ITS PARTS: HOW SUPPLIER COLLABORATION DRIVES SUCCESSFUL COMBINATION PRODUCTS
Bernd Zeiss, Lucy Lee and Sébastien Cordier discuss the multitudinous advantages of collaboration between suppliers and pharma partners, from boosting innovation to optimising component choices for device development early on, all while ensuring compliance with global regulatory standards.
SMARTER FOR BUDGETS & KINDER TO THE PLANET: ECOSAFE<sup>®</sup> SAFETY SYRINGE PLATFORM
SUSTAINABILITY
Tim Holden
Owen Mumford
SMARTER FOR BUDGETS & KINDER TO THE PLANET: ECOSAFE® SAFETY SYRINGE PLATFORM
Tim Holden describes the key objectives behind Owen Mumford’s 1 mL safety syringe injection platform and how the company sought to provide a single platform for all patients (able, less dexterous and needle-phobic) while minimising cost, waste and carbon footprint impact.
A NOVEL FORCE-MODELLING METHOD & SOFTWARE FOR ACCELERATING TIME TO MARKET FOR NEW INJECTION DEVICES
PREFILLED SYRINGES
Bradley Sawyer
Sanner Group
A NOVEL FORCE-MODELLING METHOD & SOFTWARE FOR ACCELERATING TIME TO MARKET FOR NEW INJECTION DEVICES
Bradley Sawyer, Elena Guss Tarazona,  Matthew Latham, Charlie Bowen, Dr Jay Sayed, and Harriet Field describe new software co-developed by Sanner Group and Pfizer to translate syringe test data into injection device performance, and to work backwards from device performance after shelf-life expiration to the maximum forces they can allow in a syringe test.
ADVANCEMENTS IN INTRADERMAL DELIVERY: FROM HISTORIC TECHNIQUES TO MODERN INNOVATIONS
INJECTION
Michele Guasti
Terumo Medical Care Solutions
ADVANCEMENTS IN INTRADERMAL DELIVERY: FROM HISTORIC TECHNIQUES TO MODERN INNOVATIONS
Michele Guasti explores the evolution of intradermal delivery methods, comparing historic methods of delivery, such as the Mantoux technique, with modern innovations, such as the Terumo Immucise™ intradermal injection system. The article goes on to discuss the expanding applications of intradermal delivery, including its potential for targeted lymph node delivery.
WHY YOU CANNOT DESIGN A PREFILLED SYRINGE SYSTEM OUT OF COMPONENTS
INJECTION
Dr Bettine Boltres
West Pharmaceutical Services
WHY YOU CANNOT DESIGN A PREFILLED SYRINGE SYSTEM OUT OF COMPONENTS
Dr Bettine Boltres unravels the complexities of bringing a new molecule to market as part of a combination product and rethinks the way that drug-device design could be tackled instead, approaching the system as a whole rather than through individual component development.
A CONFIGURABLE PATIENT-CENTRIC DELIVERY PLATFORM FOR BIOLOGICS AND HIGH CONCENTRATION FORMULATIONS
INJECTION
Asmita Khanolkar
SMC Ltd
A CONFIGURABLE PATIENT-CENTRIC DELIVERY PLATFORM FOR BIOLOGICS AND HIGH CONCENTRATION FORMULATIONS
Asmita Khanolkar and Marta Vilaplana, explore key challenges in delivering complex biologics and formulations, as well as the importance of early device involvement in preclinical development. They go on to consider how configurable platform technologies can support delivery of biologics, suspensions and high-viscosity formulations.
A HOME for Your Molecule – Lifecore Biomedical
VIDEO
Lifecore Injectables
A HOME for Your Molecule – Lifecore Biomedical
More than a parenteral CDMO, your discovery deserves a home. A home where the level of care is unmatched. Learn why Lifecore Biomedical is the right home for your molecule.
Interview: Making Dual-Chamber Systems a Viable Alternative
INTERVIEW
Laxman Halleppanavar
Credence MedSystems
Interview: Making Dual-Chamber Systems a Viable Alternative
In this exclusive interview, Laxman Halleppanavar and Guy Furness discuss industry trends and challenges with injectable delivery, and how Credence MedSystems' dual-chamber devices provide solutions to address those challenges. Mr Halleppanavar goes into details of Credence’s role in this increasingly important sector of the drug delivery market, explaining the company’s approach to device design, development and overcoming the barriers posed by supply chain management.
HIGH SPEED LASER ASSEMBLY – FLEXIBLE MACHINE CONCEPTS WITH FULL LASER INTEGRATION
INDUSTRIALISATION
Matthias Müller
Contexo
HIGH SPEED LASER ASSEMBLY – FLEXIBLE MACHINE CONCEPTS WITH FULL LASER INTEGRATION
Matthias Müller discusses the advantages of including laser technology in drug delivery device manufacturing, covering the various ways in which this technology can be applied and used to provide efficient, cost-effective and clean processes at high throughput rates.
DE-RISKING A NOVEL VALVE COMPONENT FOR USE WITH STANDARD SYRINGE AND AUTOINJECTOR PLATFORMS
DUAL CHAMBER
Marc Flippe
BD (Becton Dickinson & Company)
DE-RISKING A NOVEL VALVE COMPONENT FOR USE WITH STANDARD SYRINGE AND AUTOINJECTOR PLATFORMS
Marc Flippe and Sophie Lelias introduce a novel valve component designed to enable dual-chamber functionality within standard syringe and autoinjector platforms. Developed through a comprehensive modelling and development framework, the BD dual-injection syringe system provides a scalable solution to dual-chamber injection that reduces the burden of change by preserving compatibility with established container formats and device architectures.
IMPROVING THE SELF-ADMINISTRATION OF LYO- AND LIQUID-LIQUID FORMULATIONS
DUAL CHAMBER
Bjørn Knud Andersen
Phillips Medisize
IMPROVING THE SELF-ADMINISTRATION OF LYO- AND LIQUID-LIQUID FORMULATIONS
Bjørn Andersen and Iain Simpson explore the factors contributing to interest in lyo-liquid and liquid-liquid drug delivery, highlighting some of the current unmet needs in this space. Following this, they discuss how platform technologies, such as electromechanical drives, may help address these unmet needs.
TWO INTO ONE: SOLVING COMPLEX DRUG DELIVERY PROBLEMS WITH DUAL-CHAMBER CONTAINMENT SOLUTIONS
DUAL CHAMBER
Enrico Barichello
Stevanato Group
TWO INTO ONE: SOLVING COMPLEX DRUG DELIVERY PROBLEMS WITH DUAL-CHAMBER CONTAINMENT SOLUTIONS
Enrico Barichello and Valerio Ravazzolo describe how dual-chamber solutions ensure isolation, integrity and safety for managing lyophilised and liquid drugs. With innovative and customisable designs, these technologies improve drug delivery, reduce contamination risks and simplify complex therapies, addressing the evolving needs of both pharmaceutical industry and patients.
ADVANCING LYOPHILISED DRUG DELIVERY WITH REUNITE™: RECONSTITUTION MADE SIMPLE
DUAL CHAMBER
Dr Nina Fetz
SHL Medical
ADVANCING LYOPHILISED DRUG DELIVERY WITH REUNITE™: RECONSTITUTION MADE SIMPLE
Dr Nina Fetz introduces SHL Medical's Reunite®, the first and only commercialised dual-chamber cartridge, three-step autoinjector featuring the company’s Needle Isolation Technology. With automated reconstitution, Reunite enables reliable self-injection of lyophilised formulations, supporting home-based care models.
BEYOND THE BARREL: A DUAL-CARTRIDGE IMPROVEMENT TO TRADITIONAL DUAL-CHAMBER DEVICES
DUAL CHAMBER
Dr Brent Buchine
Windgap Medical
BEYOND THE BARREL: A DUAL-CARTRIDGE IMPROVEMENT TO TRADITIONAL DUAL-CHAMBER DEVICES
Dr Brent Buchine explores how Windgap Medical’s devices transform dual-chamber systems with a modular, scalable and remarkably simple approach to reconstitution and complex drug delivery.
FROM HOSPITAL TO HOME HEALTHCARE: ADVANCES IN LYOPHILISED PRODUCT DELIVERY
EXPERT VIEW
Edward Trappler
FROM HOSPITAL TO HOME HEALTHCARE: ADVANCES IN LYOPHILISED PRODUCT DELIVERY
Edward Trappler, Denise Miller and Michael Thomas discuss the challenges for lyophilised products and consider the role of dual-chamber devices in simplifying reconstitution, particularly for at-home healthcare products, and go on to look at how future advances in delivery devices are providing safe solutions for self-administration while improving patient adherence.
POWDER TO THE PEOPLE: ACCELERATING ACCESS TO LYOPHILISED THERAPIES
EXPERT VIEW
Kristien De Clercq
POWDER TO THE PEOPLE: ACCELERATING ACCESS TO LYOPHILISED THERAPIES
Kristien De Clercq and Dr Alex Vasiev discuss the challenges and recent advances in drying and reconstitution technologies, as well as how, while dual-chamber primary packaging offers a potential solution for simplifying reconstitution, it remains underused due to usability concerns and a prevailing industry preference for vial-based lyophilisation over alternative drying methods such as spray drying and powder filling.
ADVANCING LYOPHILISED DRUG DEVELOPMENT IN DUAL-CHAMBER SYSTEMS
DUAL CHAMBER
Dr Markus Neumeier
Vetter Pharma
ADVANCING LYOPHILISED DRUG DEVELOPMENT IN DUAL-CHAMBER SYSTEMS
Dr Markus Neumeier details the lyophilisation process and the range of elements that need to be examined for a dual-chamber system undergoing freeze-drying, while also laying out the quality control processes to conduct when transitioning from the laboratory to industrial-scale operations.
Early Insight: RETHINKING DUAL-CHAMBER SYRINGES: A LATERAL APPROACH TO FASTER, SAFER RECONSTITUTION
EARLY INSIGHT
Eric Sugalski
Ampulis
Early Insight: RETHINKING DUAL-CHAMBER SYRINGES: A LATERAL APPROACH TO FASTER, SAFER RECONSTITUTION
Eric Sugalski examines the limitations of current concentric dual-chamber syringe designs and explores a novel, lateral-chamber approach from Ampulis – the Ampulis Reconstitution Syringe.
Early Insight: DuoVIAL<sup>®</sup> – PROTECT, MIX AND DELIVER
EARLY INSIGHT
Gareth Pearce
Pacifi Ltd
Early Insight: DuoVIAL® – PROTECT, MIX AND DELIVER
Gareth Pearce introduces Pacifi's DuoVIAL® primary packaging technology for topical lyophilised formulations – a minimalist dual-chamber drug delivery system that enables safer, easier and more cost-effective reconstitution, while retaining the proven materials, formats and filling processes well established in the pharmaceutical sector.
DELIVERING COMPLEXITY: DEVICE CONSIDERATIONS FOR TWO-COMPONENT INJECTABLE FORMULATIONS
EXPERT VIEW
María FM Balson
DELIVERING COMPLEXITY: DEVICE CONSIDERATIONS FOR TWO-COMPONENT INJECTABLE FORMULATIONS
María FM Balson weighs up strengths and limitations when developing devices for lyophilised injectables, exploring their growing demand and the impacts of formulation, device type and design on the feasibility for bringing a device to market to deliver these essential therapies.
DIVERGENT DESIGN PHILOSOPHIES IN THE WEARABLE INJECTOR SEGMENT
WEARABLES
Reto Jost
Ypsomed
DIVERGENT DESIGN PHILOSOPHIES IN THE WEARABLE INJECTOR SEGMENT
Reto Jost and Daniel Käser detail how Ypsomed is approaching wearable injector design with YpsoDose and achieving large-volume requirements, consistent dosing and low residual waste, going on to explain how the company’s design choices are integrated with patient-centric features to ensure adherence and comfort.
SYMBIOZE<sup>®</sup> – THE ELECTROMECHANICAL ON-BODY DRUG DELIVERY SYSTEM FOR LARGE-VOLUME IMMUNOTHERAPIES
WEARABLES
Corinne Malica
Nemera
SYMBIOZE® – THE ELECTROMECHANICAL ON-BODY DRUG DELIVERY SYSTEM FOR LARGE-VOLUME IMMUNOTHERAPIES
Corinne Malica and Cécile Gross discuss the challenges involved in developing a wearable device for on-body drug delivery of advanced biologics, with a focus on the immunotherapy sector, and the technical solutions that can overcome them, using Nemera’s Symbioze® as an example.
ON-BODY INJECTORS: A PROMISING SOLUTION TO THE UK’S SYSTEMIC ANTI-CANCER THERAPY CRISIS
WEARABLES
Omar Rahman
Enable Injections
ON-BODY INJECTORS: A PROMISING SOLUTION TO THE UK’S SYSTEMIC ANTI-CANCER THERAPY CRISIS
Omar Rahman, Catherine Loughran and Rachel Senior consider how on-body injectors, such as Enable’s enFuse, can help to reduce the administrative burden on the healthcare system as well as giving patients more autonomy and dignity in managing their disease.
REDEFINING PATIENT-CENTRIC DRUG DELIVERY: A CLOSER LOOK AT VERTIVA<sup>®</sup> ON-BODY DELIVERY SYSTEM
WEARABLES
Anna Allegro
Stevanato Group
REDEFINING PATIENT-CENTRIC DRUG DELIVERY: A CLOSER LOOK AT VERTIVA® ON-BODY DELIVERY SYSTEM
Anna Allegro explores current challenges in wearable injectors and how the next generation of on-body delivery systems, such as Stevanato’s Vertiva® platform, aims to close the gap between technical performance and true patient centricity.
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