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INJECTION

FROM HOSPITAL TO HOME HEALTHCARE: ADVANCES IN LYOPHILISED PRODUCT DELIVERY
EXPERT VIEW
Edward Trappler
FROM HOSPITAL TO HOME HEALTHCARE: ADVANCES IN LYOPHILISED PRODUCT DELIVERY
Edward Trappler, Denise Miller and Michael Thomas discuss the challenges for lyophilised products and consider the role of dual-chamber devices in simplifying reconstitution, particularly for at-home healthcare products, and go on to look at how future advances in delivery devices are providing safe solutions for self-administration while improving patient adherence.
POWDER TO THE PEOPLE: ACCELERATING ACCESS TO LYOPHILISED THERAPIES
EXPERT VIEW
Kristien De Clercq
POWDER TO THE PEOPLE: ACCELERATING ACCESS TO LYOPHILISED THERAPIES
Kristien De Clercq and Dr Alex Vasiev discuss the challenges and recent advances in drying and reconstitution technologies, as well as how, while dual-chamber primary packaging offers a potential solution for simplifying reconstitution, it remains underused due to usability concerns and a prevailing industry preference for vial-based lyophilisation over alternative drying methods such as spray drying and powder filling.
ADVANCING LYOPHILISED DRUG DEVELOPMENT IN DUAL-CHAMBER SYSTEMS
DUAL CHAMBER
Dr Markus Neumeier
Vetter Pharma
ADVANCING LYOPHILISED DRUG DEVELOPMENT IN DUAL-CHAMBER SYSTEMS
Dr Markus Neumeier details the lyophilisation process and the range of elements that need to be examined for a dual-chamber system undergoing freeze-drying, while also laying out the quality control processes to conduct when transitioning from the laboratory to industrial-scale operations.
Early Insight: RETHINKING DUAL-CHAMBER SYRINGES: A LATERAL APPROACH TO FASTER, SAFER RECONSTITUTION
EARLY INSIGHT
Eric Sugalski
Ampulis
Early Insight: RETHINKING DUAL-CHAMBER SYRINGES: A LATERAL APPROACH TO FASTER, SAFER RECONSTITUTION
Eric Sugalski examines the limitations of current concentric dual-chamber syringe designs and explores a novel, lateral-chamber approach from Ampulis – the Ampulis Reconstitution Syringe.
Early Insight: DuoVIAL<sup>®</sup> – PROTECT, MIX AND DELIVER
EARLY INSIGHT
Gareth Pearce
Pacifi Ltd
Early Insight: DuoVIAL® – PROTECT, MIX AND DELIVER
Gareth Pearce introduces Pacifi's DuoVIAL® primary packaging technology for topical lyophilised formulations – a minimalist dual-chamber drug delivery system that enables safer, easier and more cost-effective reconstitution, while retaining the proven materials, formats and filling processes well established in the pharmaceutical sector.
DELIVERING COMPLEXITY: DEVICE CONSIDERATIONS FOR TWO-COMPONENT INJECTABLE FORMULATIONS
EXPERT VIEW
María FM Balson
DELIVERING COMPLEXITY: DEVICE CONSIDERATIONS FOR TWO-COMPONENT INJECTABLE FORMULATIONS
María FM Balson weighs up strengths and limitations when developing devices for lyophilised injectables, exploring their growing demand and the impacts of formulation, device type and design on the feasibility for bringing a device to market to deliver these essential therapies.
DIVERGENT DESIGN PHILOSOPHIES IN THE WEARABLE INJECTOR SEGMENT
WEARABLES
Reto Jost
Ypsomed
DIVERGENT DESIGN PHILOSOPHIES IN THE WEARABLE INJECTOR SEGMENT
Reto Jost and Daniel Käser detail how Ypsomed is approaching wearable injector design with YpsoDose and achieving large-volume requirements, consistent dosing and low residual waste, going on to explain how the company’s design choices are integrated with patient-centric features to ensure adherence and comfort.
SYMBIOZE<sup>®</sup> – THE ELECTROMECHANICAL ON-BODY DRUG DELIVERY SYSTEM FOR LARGE-VOLUME IMMUNOTHERAPIES
WEARABLES
Corinne Malica
Nemera
SYMBIOZE® – THE ELECTROMECHANICAL ON-BODY DRUG DELIVERY SYSTEM FOR LARGE-VOLUME IMMUNOTHERAPIES
Corinne Malica and Cécile Gross discuss the challenges involved in developing a wearable device for on-body drug delivery of advanced biologics, with a focus on the immunotherapy sector, and the technical solutions that can overcome them, using Nemera’s Symbioze® as an example.
ON-BODY INJECTORS: A PROMISING SOLUTION TO THE UK’S SYSTEMIC ANTI-CANCER THERAPY CRISIS
WEARABLES
Omar Rahman
Enable Injections
ON-BODY INJECTORS: A PROMISING SOLUTION TO THE UK’S SYSTEMIC ANTI-CANCER THERAPY CRISIS
Omar Rahman, Catherine Loughran and Rachel Senior consider how on-body injectors, such as Enable’s enFuse, can help to reduce the administrative burden on the healthcare system as well as giving patients more autonomy and dignity in managing their disease.
REDEFINING PATIENT-CENTRIC DRUG DELIVERY: A CLOSER LOOK AT VERTIVA<sup>®</sup> ON-BODY DELIVERY SYSTEM
WEARABLES
Anna Allegro
Stevanato Group
REDEFINING PATIENT-CENTRIC DRUG DELIVERY: A CLOSER LOOK AT VERTIVA® ON-BODY DELIVERY SYSTEM
Anna Allegro explores current challenges in wearable injectors and how the next generation of on-body delivery systems, such as Stevanato’s Vertiva® platform, aims to close the gap between technical performance and true patient centricity.
ADVANCING CANCER CARE THROUGH ON-BODY SUBCUTANEOUS INJECTIONS: THE ONCOLOGY COMMUNITY’S PERSPECTIVE
EXPERT VIEW
Dr Greg Moakes
ADVANCING CANCER CARE THROUGH ON-BODY SUBCUTANEOUS INJECTIONS: THE ONCOLOGY COMMUNITY’S PERSPECTIVE
Dr Greg Moakes discusses the role that on-body delivery systems have to play in modernising the delivery of oncology drugs, digging into the survey results of over 200 attendees of the American Society of Clinical Oncology 2025 Global Meeting as to their opinions on the place of this pivotal technology in oncological practice.
DEVICE DESIGN TO ADDRESS USABILITY AND MITIGATE USE-RELATED RISKS – A MEDICAL AFFAIRS AND HUMAN FACTORS PERSPECTIVE
WEARABLES
Dr Sylvine Raverdy-Wilson
BD (Becton Dickinson & Company)
DEVICE DESIGN TO ADDRESS USABILITY AND MITIGATE USE-RELATED RISKS – A MEDICAL AFFAIRS AND HUMAN FACTORS PERSPECTIVE
Dr Sylvine Raverdy-Wilson deep dives into the device constituent of drug-device combination product design and shares perspectives through the Use-Related Risk Analysis methodology with a focus on the BD Libertas™ Wearable Injector.
VISTA BY TXSPHERE: TRAVERSING THE LIMITATIONS OF SMALL-VOLUME BIOLOGICS
WEARABLES
Dr Chaoyoung Lee
TxSphere
VISTA BY TXSPHERE: TRAVERSING THE LIMITATIONS OF SMALL-VOLUME BIOLOGICS
Dr Chaoyoung Lee and Mike Stout unveil an innovative addition to TxSphere's wearable platform, Vista, designed to improve on efficiency goals, adapt to varied drug formulations and advance beyond the requirements of low-volume drug delivery.
INJECTING DRUGS DIRECTLY INTO THE BODY: HOW ON-BODY DELIVERY SYSTEMS ARE REVOLUTIONISING THERAPY
WEARABLES
Peter Schmidt
ZwickRoell
INJECTING DRUGS DIRECTLY INTO THE BODY: HOW ON-BODY DELIVERY SYSTEMS ARE REVOLUTIONISING THERAPY
Peter Schmidt discusses the advantages of on-body delivery systems and what makes them special, going on to consider the significant role that they are expected to play in the future of injection technology for the pharmaceutical and medical fields, as well as the role that comprehensive testing plays in bringing this technology to patients.
ACCELERATING DEVELOPMENT OF ELECTROMECHANICAL DELIVERY SYSTEMS VIA MODULAR INTEGRATION
WEARABLES
Nicholas Ciccarelli
Kymanox
ACCELERATING DEVELOPMENT OF ELECTROMECHANICAL DELIVERY SYSTEMS VIA MODULAR INTEGRATION
Nicholas Ciccarelli, Andrew King, Dr Marcus Herrmann and Dr Thomas Roschke, discuss the insights gained in the product development process from the recent collaboration between the two companies, with Kymanox managing the overall system integration and Johnson MedTech tackling the specific design of the drive system within the designated product specification.
SAFE AND SKIN-FRIENDLY MANUFACTURING OF MEDICAL WEARABLES WITH ULTRASONIC WELDING
EXPERT VIEW
Michael Boerner
SAFE AND SKIN-FRIENDLY MANUFACTURING OF MEDICAL WEARABLES WITH ULTRASONIC WELDING
Michael Boerner looks at the key factors for designing skin-friendly medical wearables and how to manufacture them safely, automatically and sustainably.
SELF-INJECTION DEVICE MANUFACTURING IN A DYNAMIC WORLD
INDUSTRIALISATION
Philipp Richard
Ypsomed
SELF-INJECTION DEVICE MANUFACTURING IN A DYNAMIC WORLD
Philipp Richard scrutinises the efficient production of self-injection devices in the pharma industry and describes Ypsomed’s own platforms for developing these devices, highlighting the need to be adaptable and resilient to the rapidly evolving world of drug development. He provides valuable insights into the ways in which the flexible manufacture of self-injection devices might be achieved.
Interview: SHL Advantec – SHL Medical’s New Manufacturing Equipment Sub-Group
INTERVIEW
Gilbert Fluetsch
SHL Advantec
Interview: SHL Advantec – SHL Medical’s New Manufacturing Equipment Sub-Group
Gilbert Fluetsch discusses the establishment of SHL Advantec and the foundation it has built as SHL Medical’s in-house equipment specialist. Mr Fluetsch also looks at the role of modular platforms in scaling production and how the company’s global network is designed to support the changing landscape of medical and pharma manufacturing.
FINDING COMMON GROUND: FACTORS FOR ESTABLISHING AND SAFEGUARDING SHELF LIFE IN COMBINATION PRODUCTS
INDUSTRIALISATION
Lauren Orme
West Pharmaceutical Services
FINDING COMMON GROUND: FACTORS FOR ESTABLISHING AND SAFEGUARDING SHELF LIFE IN COMBINATION PRODUCTS
Lauren Orme discusses the regulatory considerations that need to be taken into account when designing combination products. She reviews the essential testing and standards required for both drug and device when establishing their shelf life and storage in a combined product.
CDMOs AS STRATEGIC ENABLERS FOR DEVICE INDUSTRIALISATION
INDUSTRIALISATION
Adam Nightingale
Sanner Group
CDMOs AS STRATEGIC ENABLERS FOR DEVICE INDUSTRIALISATION
Adam Nightingale explores a multitude of approaches to achieving more efficient and sustainable production of medical devices when partnering with a CDMO, and demonstrates the ways in which these partnerships can offer reduced risk and comply with regulations when streamlining industrialisation.
MASTERING COMMERCIAL MANUFACTURING FOR STERILE INJECTABLES
EXPERT VIEW
Jennifer Gattari
MASTERING COMMERCIAL MANUFACTURING FOR STERILE INJECTABLES
Jennifer Gattari delves into what is required to succeed at the commercial phase of sterile injectable manufacturing, going on to explore the challenges that companies can expect and the critical strategies that can help ensure a smooth and scalable journey to market.
SMART ENOUGH: DESIGNING DRUG DELIVERY DEVICES THAT PUT PATIENTS FIRST
EXPERT VIEW
Andy Pidgeon
SMART ENOUGH: DESIGNING DRUG DELIVERY DEVICES THAT PUT PATIENTS FIRST
Andy Pidgeon  challenges the assumption that more advanced technology is always better, re-examining the design approach to connected autoinjectors from the patient perspective and highlighting the value of simplicity and usability – digging into the idea that, by investigating the real-world needs of patients, drug delivery device designers can ensure that their devices are serving those needs, rather than creating unnecessary new challenges for users.
Interview: PDA Miniverse and Trends in Injectable Drug Delivery
INTERVIEW
Mathias Romacker
Kymanox
Interview: PDA Miniverse and Trends in Injectable Drug Delivery
In this exclusive interview, Mathias Romacker and Evan Edwards talk with ONdrugDelivery’s Guy Furness about the upcoming inaugural PDA Miniverse conference in Indianapolis, and the topics and trends currently being felt across the injectable drug delivery industry.
Introducing Instron<sup>®</sup> AVE3 Advanced Video Extensometer
VIDEO
Landon Goldfarb
Instron
Introducing Instron® AVE3 Advanced Video Extensometer
This video introduces Instron’s premier extensometer solution, the AVE3. It is unrivaled in versatility, offering precision strain measurement for tensile, compression, and bend testing.
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