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PULMONARY

AN OVERVIEW OF DRY POWDER INHALATION FOR SYSTEMIC DRUG DELIVERY
PULMONARY
Brian E Jones
Qualicaps
AN OVERVIEW OF DRY POWDER INHALATION FOR SYSTEMIC DRUG DELIVERY
Brian Jones and Susana Ecenarro Probst discuss the growing interest in using inhaled APIs to treat systemic conditions. Furthermore, they review some of the methods used to engineer molecules to be suitable for DPI capsules and look to the possibility of administering biomolecules via the pulmonary route.
DEVELOPING EFFECTIVE TRAINING DEVICES FOR THE PULMONARY HEALTHCARE MARKET
PULMONARY
Joe Reynolds
Noble
DEVELOPING EFFECTIVE TRAINING DEVICES FOR THE PULMONARY HEALTHCARE MARKET
Pulmonary drug delivery is an effective route of pharmaceutical administration but research has shown that a large majority of patients fail to use their devices properly, training devices can help address this problem. Joe Reynolds looks at the design challenges that need to be addressed as well as some of the latest features that can be incorporated to develop optimal training devices for patients.
A NOVEL POWDER FILLING TECHNOLOGY TO REDUCE DEVELOPMENT COSTS & TIMELINES
PULMONARY
Simon Strothers
3P Innovation
A NOVEL POWDER FILLING TECHNOLOGY TO REDUCE DEVELOPMENT COSTS & TIMELINES
Simon Strothers and Dave Seaward discuss the evolution of filling technology in the inhaled world, including a new technology and approach to filling which offers significant advantages over conventional filling systems.
KEY CONSIDERATIONS FOR NON-CLINICAL SAFETY ASSESSMENT OF INHALED BIOPHARMACEUTICALS
EXPERT VIEW
Dr Simon Moore
KEY CONSIDERATIONS FOR NON-CLINICAL SAFETY ASSESSMENT OF INHALED BIOPHARMACEUTICALS
Simon Moore, Kirsty Haprer and Sylwia Marshall highlight some of the key considerations for the development of inhaled biopharmaceuticals, including non-clinical safety assessment.
WHAT IS QUALITY BY DESIGN AND WHY SHOULD YOU CARE?
PULMONARY
Proveris Scientific
WHAT IS QUALITY BY DESIGN AND WHY SHOULD YOU CARE?
Proveris Scientific explains quality by design (QbD), a scientific approach that formalises product design, automates manual testing, and streamlines troubleshooting.
THE IMPORTANCE OF SPRING AND STAMPING QUALITY IN INHALER SAFETY
PULMONARY
Bergdis Vogt
Baumann Medical
THE IMPORTANCE OF SPRING AND STAMPING QUALITY IN INHALER SAFETY
Frank Reiss and Bergdis Sigurdardottir explain how medical competence in spring and stamping manufacturing may prove critical for the developers of inhalers.
TRAINING DEVICE OPPORTUNITIES
PULMONARY
Joe Reynolds
Noble
TRAINING DEVICE OPPORTUNITIES
Joe Reynolds outlines the increasing range of options available for helping patients learn how to use their devices correctly and maximise the effectiveness of their treatments.
DIMITRI GRASSWILL, NEMERA
INTERVIEW
Dimitri Grasswill
Nemera
DIMITRI GRASSWILL, NEMERA
Dimitri Grasswill speaks with ONdrugDelivery Magazine, in the context of the changing market and technology around inhalation devices.
PRODUCT SHOWCASE: APTAR PHARMA’S MDI eDOSE COUNTER
PULMONARY
Aptar Pharma
PRODUCT SHOWCASE: APTAR PHARMA’S MDI eDOSE COUNTER
Aptar Pharma, will unveil its latest innovation, the eDose Counter for metered dose inhalers (MDIs), at the RDD Europe scientific conference in Antibes, France, on April 25-28, 2017.
DOSE COUNTERS & INDICATORS – MEETING A REAL PATIENT NEED
PULMONARY
Inga Meyer
H&T Presspart
DOSE COUNTERS & INDICATORS – MEETING A REAL PATIENT NEED
Inga Meyerand Kyle Wilson explain how their dose counter-enabled inhaler development work has led to the production of a system that accurately indicates the end of life of a device.
BILL WELCH, PHILIPS-MEDISIZE
INTERVIEW
Bill Welch
Phillips Medisize
BILL WELCH, PHILIPS-MEDISIZE
Mr Welch gives ONdrugDelivery Magazine an exclusive preview of Phillips-Medisize’s forthcoming workshop, “Realizing the Benefits of Connected Health in Respiratory Drug Delivery”.
INTEGRATED DESIGN SPACE TO DEVELOP BETTER DPI FORMULATIONS
PULMONARY
Dr Filipa Maia
Hovione
INTEGRATED DESIGN SPACE TO DEVELOP BETTER DPI FORMULATIONS
Filipa Maia and Maria Palha report a study whose objective was to establish relationships between blend rheology, product performance and capsule filling process efficiency.
THE 21ST INTERNATIONAL SOCIETY FOR AEROSOLS IN MEDICINE CONGRESS
CONFERENCE SHOWCASE
Dr Philip Kuehl
THE 21ST INTERNATIONAL SOCIETY FOR AEROSOLS IN MEDICINE CONGRESS
The International Society for Aerosols in Medicine (ISAM) is a scientific society focused on all areas of aerosols including health effects of aerosols and pulmonary drug delivery.
ASSURE INHALER SAFETY & PERFORMANCE: POLYMERS, COLOUR & ADDITIVES
EXPERT VIEW
Stephen Duckworth
ASSURE INHALER SAFETY & PERFORMANCE: POLYMERS, COLOUR & ADDITIVES
Stephen J Duckworth describes some of the application of polymer colourants and additives in respiratory drug delivery devices, highlighting the strict regulatory environment.
PRODUCT SHOWCASE: BIOCORP’S INSPAIR<sup>™</sup>
PULMONARY
Jean Vuillecard
Biocorp
PRODUCT SHOWCASE: BIOCORP’S INSPAIR™
Inspair™ is a sensing technology able to measure inhalation metrics and therefore provide an accurate insight into actual doses consumed.
SELECTION OF EXCIPIENTS FOR DRY POWDER INHALERS
EXPERT VIEW
Harry Peters
SELECTION OF EXCIPIENTS FOR DRY POWDER INHALERS
Harry Peters and Gerald Hebbink explain how, because dry powder inhalers need a carrier to help with ensuring the drug is effectively delivered, interest has been focused on developing inhalation-grade lactose for this purpose.
LEVERAGE TECH TO OVERCOME PULMONARY DELIVERY BARRIERS
PULMONARY
Jean Vuillecard
Biocorp
LEVERAGE TECH TO OVERCOME PULMONARY DELIVERY BARRIERS
Jean Vuillecard and Eric Dessertenne define the limitations of traditional strategies to train, educate and track adherence with inhaled therapeutics and show how connectivity and other add-on digital tech can support these strategies healthcare providers require.
PATIENT PREFERENCE: DEVICE TRAINING & EDUCATION TOOLS
PULMONARY
Paul Sullivan
Noble
PATIENT PREFERENCE: DEVICE TRAINING & EDUCATION TOOLS
Paul Sullivan and Craig Baker point out that most patients with asthma do not use their inhaler properly, and review evidence from a trial of five different methods designed to improve inhaler use. They conclude that training devices could be effective tools to increase patient confidence and reduce anxiety.
AN ENVIRONMENTALLY FRIENDLY & EFFICIENT DOSAGE FORM
PULMONARY
Susana Ecenarro
Qualicaps
AN ENVIRONMENTALLY FRIENDLY & EFFICIENT DOSAGE FORM
Susana Ecenarro Probst presents evidence, set against the backdrop of environmental concerns over HFC propellants in MDIs, supporting the adoption of dry-powder inhalers as an attractive alternative.
LEARNING TO WALK BEFORE WE RUN
EXPERT VIEW
David Harris
LEARNING TO WALK BEFORE WE RUN
David Harris highlights basic problems with inhalers that persist today, and describes why - as the industry looks increasingly towards developing "smart" and connected inhalers - it is important to remember to solve these basic problems.
SCALING-UP FOR HIGH DOSE DELIVERY TO THE LUNGS
PULMONARY
Dr João Ventura Fernandes
SCALING-UP FOR HIGH DOSE DELIVERY TO THE LUNGS
João Ventura Fernandes, Gonçalo Rebelo de Andrade and Peter Villax describe the scaling up of the currently marketed TwinCaps® inhaler into the new TwinMax™ design for high-dose delivery of challenging drug-alone formulations in single to short-term treatments and emergency situations.
GENERIC NEBULISER BIOEQUIVALENCE: OPTIMISING ANALYTICAL STRATEGIES
PULMONARY
Déborah Le Pennec
Malvern Panalytical
GENERIC NEBULISER BIOEQUIVALENCE: OPTIMISING ANALYTICAL STRATEGIES
Déborah Le Pennec, Laurent Vecellio, Paul Kippax and Stephane Rouquette look at the optimal application of laser diffraction and automated imaging within the context of the US FDA guidance for the in vitro demonstration of bioequivalence in a generic nebuliser.
ADDING COLOUR & FUNCTIONALITY TO PLASTICS USED IN MEDICAL DEVICES
EXPERT VIEW
Stephen Duckworth
ADDING COLOUR & FUNCTIONALITY TO PLASTICS USED IN MEDICAL DEVICES
Stephen Duckworth explains how – with an emphasis on the importance of complying with stringent and changing pharmaceutical regulations – advanced additives in plastics used to make drug delivery devices can significantly enhance the product.
ENHANCING THE PERFORMANCE OF DRY POWDER INHALERS: BREATH ACTUATED MECHANISMS
PULMONARY
Alan Tweedie
ENHANCING THE PERFORMANCE OF DRY POWDER INHALERS: BREATH ACTUATED MECHANISMS
David Lewis and Alan Tweedie explain how BAMs work and present experimental data demonstrating their ability to control dose delivery.
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