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INDUSTRIALISATION
INJECTION
DUAL CHAMBER
FORMULATION
PFS
WEARABLES
ALL INJECTION
OCULAR
ORAL
RESPIRATORY
PULMONARY
NASAL
ALL RESPIRATORY
MORE
INTERVIEWS
EXPERT VIEWS
EARLY INSIGHTS
COMPANY LISTINGS
OUR AUTHORS
THE MAGAZINE
EVENTS
ED CALENDAR
CONTRIBUTE
MEDIA PACK
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GI/ORAL
EARLY INSIGHT
Sarah Trenfield
FabRx
PERSONALISING DRUG PRODUCTS USING 3D PRINTING
Sarah Trenfield and Abdul Basit look at the potential applications of 3D-printing technology to create personalised drug therapies in fields such as multiple drug therapy and paediatric/geriatric care and introduce FabRx’s 3D-printing system, which can produce formulations to suit a variety of situations.
EXPERT VIEW
Jamie Clayton
3D PRINTING DRUGS: LEARNING FROM THE PIONEERS
Jamie Clayton reviews the potential of 3D printing as a pharmaceutical production method and looks at the associated implications for formulation development, focusing on powder-based printing. He examines what leading experts now understand about how to specify powder feeds for 3D printing.
EXPERT VIEW
Dr Aline Moulin
COMPACTION SIMULATION / INDUSTRIAL PRESS CORRELATION: TWO CASE STUDIES
Aline Moulin and Lucile Kowalski examine two case studies comparing compaction simulation with industrial compression.
INDUSTRIALISATION
Jose Luis Encinas
Qualicaps
QUALI-V EXTRA DRY: A NOVEL CAPSULE FOR DELIVERING HYGROSCOPIC FORMULATIONS
Jose Luis Encinas and Susana Ecenarro explore how the use of Quali-V
®
Extra Dry capsules can help improve product stability and, crucially, lead to efficiencies and savings in drug product manufacture.
EXPERT VIEW
Dr Nidhi Prakash Sapkal
ORAL THIN FILMS: NOVEL TECHNOLOGY & ITS CHALLENGES
Presented from both the technology and formulation perspectives, Nidhi Prakash Sapkal and Anwar Siraj Daud discuss the challenges of industrialising oral thin films, a promising but difficult dosage form.
INDUSTRIALISATION
Hugues Benevent
Unither Pharmaceuticals
THE ODTECH PLATFORM: A RANGE OF READY-TO-USE ORAL FORMS
Hugues Benevent and Nathalie Masson introduce the ODtech™ platform technology for oral medications, designed to provide an easy-to-use and ready-to-industrialise solution for tackling the human factors issues of standard oral pills.
EXPERT VIEW
Jonathan Gaik
GO WITH THE FLOW – SOLVING POWDER FLOW CHALLENGES BEFORE PRODUCTION
Jonathan Gaik discusses the various problems in tablet compression that can be caused by not giving due care to powder flow in the development stage and how, by doing so, what would be serious problems at the industrial scale can be solved in advance.
EXPERT VIEW
Dr Damon C Smith
PREVENTION NOT CURE: AVOIDING A EUROPEAN PRESCRIPTION OPIOID EPIDEMIC
Damon Smith, Richard Dart and Christopher Hirst discuss the causes and possible solutions to the prescription opioid epidemic, as well as whether or not Europe is likely to face a similar fate.
GI/ORAL
Cécile Morin
HIGH SHEAR COATING: A VERSATILE TASTE-MASKING PROCESS
Cécile Morin and Yvonne Rosiaux discuss taste-masking, covering the advantages of Precirol
®
ATO 5 and how Gattefossé’s high shear coating process presents an appealing alternative to standard fluid bed techniques.
EXPERT VIEW
Rob Davidson
ORAL FILMS – A MULTI-FACETED DRUG DELIVERY SYSTEM AND DOSAGE FORM
Oral films are a relative newcomer to the drug delivery space, though one with considerable potential. Rob Davidson and Jessica Rousset give an overview of this dosage form, from formulation through manufacturing to future outlook.
GI/ORAL
Dr Anna Malori
Bormioli Pharma
ORAL DRUG RECONSTITUTION: MAKING IT EASY AND ACCURATE VIA PACKAGING INNOVATION
Anna Malori discusses the oft overlooked challenges and difficulties of standard packaging systems for oral medications requiring reconstitution before use.
EXPERT VIEW
Rashmi Nair
THE SCIENCE OF SOLUBILITY AND THE SUCCESS OF AMORPHOUS SOLID DISPERSIONS
Rashmi Nair discusses the persistent challenge presented by poorly soluble drug formulations in oral drug delivery. Furthermore, she goes on to highlight the promise shown by amorphous solid dispersions, despite the difficulties they present.
GI/ORAL
Dr Michael Baumann
EXCIPIENT INNOVATION REQUIRES CLOSE COLLABORATION
Michael Baumann discusses the need for novel excipients in new drug development, the regulatory difficulties inherent to developing novel excipients and methods of innovation using current compendial excipients.
GI/ORAL
Dr Maria Montero Mirabet
Evonik
ADVANCED APPROACHES FOR DELAYED-RELEASE FORMULATIONS
Maria Montero Mirabet and Brigitte Skalsky, both of Evonik Health Care, review advances in delayed-release technology including advances in enteric-coating applications and the use of pulsatile technology to provide tailored lag times.
GI/ORAL
Don Barbieri
MEETING THE CHALLENGES OF PAEDIATRIC DOSING
Although paediatric drugs are traditionally administered in a liquid formulation, recent studies suggest that orally disintegrating mini-tablets may be a more accurate, convenient and less messy dosage form. Don Barbieri explores this method and reviews two case studies looking at whether quality standards can be met and the importance of taste in paediatric formulations.
EXPERT VIEW
Dr S Mohan Mohanraj
EVALUATING A NEW MICROSPHERE BASED CONTROLLED-RELEASE DELIVERY SYSTEM
S Mohan Mohanraj and Meir Kende discuss the development of a microsphere based delivery system for an orally administered anthrax vaccine.
GI/ORAL
Aia Malik
THE PRESCRIPTION ABUSE EPIDEMIC: DESIGNING A SOLUTION
Aia Malik and Gemma Budd discuss the journey behind Lucideon’s proprietary iCRTdeter technology which provides tamper-proofing and enhanced safety of pharmaceuticals. It has been used to give abuse-deterrent features to formulations of opioids and highly potent compounds.
GI/ORAL
Dr Carmen Popescu
Roquette
ORALLY DISINTEGRATING FILMS FOR THE DELIVERY OF BIOTHERAPEUTICS & NANO / MICROPARTICLE FORMULATIONS
Carmen Popescu summarises the benefits and applications of orally dissolving film dosage forms, with claims supported by two case studies, one demonstrating the suitability of ODFs for the delivery of micro and nanoparticles, the other showing how this property of ODFs exhibits promise as a next-generation immunisation system.
GI/ORAL
Dr Nathan Dormer
SINGLE-STEP FUNCTIONAL COATINGS FOR INCREASED EFFICIENCIES
In this article about oral drug innovation, Cory Berkland and Nathan Dormer focus on how enterics and reverse enterics are applied into dosage forms, and discuss the future of this class of drug formulation technology.
GI/ORAL
Dr Sejal R Ranmal
OPPORTUNITIES & INNOVATIONS IN COLONIC DRUG DELIVERY
Sejal R Ranmal, Vipul Yadav and Abdul W Basit describe recent insights into the physiology of the colon, advantages of targeting drug release to the colon and introduce Phloral®, Intract’s unique system for achieving drug release in the colon successfully and consistently.
EXPERT VIEW
Dr Nozer Mehta
TECHNOLOGIES & CLINICAL STUDIES FOR THE ORAL DELIVERY OF CALCITONIN
Nozer Mehta, James P Gilligan and William Stern summarise the different technologies that have been in development for oral delivery of peptides through the gastro-intestinal mucosal surfaces via the transcellular or the paracellular pathways and describe the results of several long-term clinical studies on the oral delivery of salmon calcitonin.
EXPERT VIEW
Stephen Tindal
SELECTING OPTIMAL FORMULATION TECHNOLOGY FOR BETTER TREATMENT
Stephen Tindal provides reviews strategies for oral formulation selection which can lower attrition rates, and therefore development costs and time to market.
GI/ORAL
Dr David Beach
ACCU-BREAK’S INNOVATIVE TABLET TECHNOLOGY – 2016 ADVANCEMENTS
David Beach provides a run-down of Accu-Break Pharmaceuticals’ tablet technologies which, among other benefits, allow patients to split tablets readily and reliably.
GI/ORAL
Hans Baer
Evonik
AN INNOVATIVE SMART ORAL DELIVERY TECHNOLOGY FOR PROTEINS AND PEPTIDES
Andrea Engel, Anne Benedikt and Hans Baer explain how their recently introduced new modular platform technology for improving the oral bioavailability of peptides may offer a feasible solution to the problem of compliance with peptide drugs.
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