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INJECTION

ENABLING A NEW PARADIGM FOR PEPTIDE DRUG DEVELOPMENT
FORMULATION
Michael Neely
Xeris Pharmaceuticals
ENABLING A NEW PARADIGM FOR PEPTIDE DRUG DEVELOPMENT
 Michael Neely reviews peptide formulations and introduces Xeris's XeriSol™ technology and its potential paradigm-changing capabilities.
RECENT TRENDS & DEVELOPMENTS IN INJECTABLE FORMULATION & DELIVERY
EXPERT VIEW
Dr Martin Gonzalez
RECENT TRENDS & DEVELOPMENTS IN INJECTABLE FORMULATION & DELIVERY
Martin Gonzalez details current trends in sterile injectable formulations and their delivery devices, and the challenges pharma and its contract development and manufacturing company partners face in bringing emerging breakthroughs to market.
INTERVIEW: STEVEN KAUFMAN, STEVANATO GROUP, & MICHAEL EARL, OWEN MUMFORD
INTERVIEW
Steven Kaufman
Stevanato Group
INTERVIEW: STEVEN KAUFMAN, STEVANATO GROUP, & MICHAEL EARL, OWEN MUMFORD
In this exclusive interview, Steven Kaufman of Stevanato Group, and Michael Earl of Owen Mumford, talked with us about their companies' recent major agreement for the manufacturing and provision of prefillable syringes for the advanced two-step, single-use autoinjector, Aidaptus®.
SUSTAINABILITY: WHAT CAN THE HEALTHCARE SECTOR LEARN FROM CONSUMER DESIGN?
SUSTAINABILITY
Fran Pencliffe
Cambridge Design Partnership
SUSTAINABILITY: WHAT CAN THE HEALTHCARE SECTOR LEARN FROM CONSUMER DESIGN?
Fran Penrose considers the lessons the healthcare sector can draw from the fast-moving consumer sector when designing for sustainability and asks, “Can we go even further?”
SMART SOLUTIONS TO REDUCE CARBON FOOTPRINT
SUSTAINABILITY
Rob Doorakkers
IGS GeboJagema
SMART SOLUTIONS TO REDUCE CARBON FOOTPRINT
Rob Doorakkers and Geert van Amstel discuss why the company decided to become carbon neutral, how it is working to make injection moulding more sustainable and how the organisation is minimising its impact on the environment.
DESIGNING DRUG DELIVERY DEVICES TO MEET EMERGING NEEDS AND SUSTAINABILITY GOALS
SUSTAINABILITY
Dr Pierre Moulinie
Covestro LLC
DESIGNING DRUG DELIVERY DEVICES TO MEET EMERGING NEEDS AND SUSTAINABILITY GOALS
Pierre Moulinié, Isaac Platte and Lauren Zetts discuss how polycarbonate-based materials deliver value to emerging drug delivery devices.
SUSTAINABILITY WITH THE ARIA AUTOINJECTOR: THE ROUTE TO FURTHER IMPROVEMENTS
SUSTAINABILITY
Emil Fraenkel
Phillips Medisize
SUSTAINABILITY WITH THE ARIA AUTOINJECTOR: THE ROUTE TO FURTHER IMPROVEMENTS
Emil Fraenkel and Bjarne Sørensen investigate the route to further sustainability improvements for the Aria autoinjector. This article is a sequel to a benchmark study on the environmental impact of Aria presented by Phillips-Medisize in ONdrugDelivery Issue 126 (Oct/Nov 2021).
SUSTAINABILITY CONSIDERATIONS FOR END-TO-END DRUG DELIVERY DEVICE SOLUTIONS
SUSTAINABILITY
Barbara Lead
SMC Ltd
SUSTAINABILITY CONSIDERATIONS FOR END-TO-END DRUG DELIVERY DEVICE SOLUTIONS
Barbara Lead outlines the sustainability efforts undertaken by SMC Group associated companies, including facilitating the transition from hospital to at-home treatment and investment in greener facilities.
HOW TEN23 HEALTH IS MEETING DEVELOPMENTAL CHALLENGES FOR INTRAVITREAL PRODUCTS
OCULAR
Dr Andrea Allmendinger
ten23 health
HOW TEN23 HEALTH IS MEETING DEVELOPMENTAL CHALLENGES FOR INTRAVITREAL PRODUCTS
Andrea Allmendinger and Hanns-Christian Mahler highlight new regulatory and quality requirements for intravitreal applications and discuss technical challenges during drug product technical development and manufacturing.
ENVISIONING NEW HORIZONS IN OCULAR DRUG DELIVERY
EXPERT VIEW
Dr Jay S Duker
ENVISIONING NEW HORIZONS IN OCULAR DRUG DELIVERY
Jay S Duker discusses the history and future of ocular drug delivery, with a special focus on posterior segment diseases and the battle to overcome significant patient and caregiver burdens.
OPHTHALMIC INJECTION OF VISCOUS FORMULATIONS – WHY UNIQUE NEEDS REQUIRE A NOVEL DELIVERY APPROACH
OCULAR
Dr Gautam Shetty
Congruence Medical Solutions
OPHTHALMIC INJECTION OF VISCOUS FORMULATIONS – WHY UNIQUE NEEDS REQUIRE A NOVEL DELIVERY APPROACH
Guatam Shetty and Richard Whelton outline the key considerations related to ophthalmic injection of viscous formulations and propose an innovative, user-validated and fully mechanical device-based solution.
A VIEW ON THE USE OF APROTIC SOLVENTS IN PARENTERAL DRUG FORMULATIONS
EXPERT VIEW
Michael Neely
A VIEW ON THE USE OF APROTIC SOLVENTS IN PARENTERAL DRUG FORMULATIONS
Michael Neely presents a review and discussion of the status of aprotic solvents as a solubilising vehicle for parenteral drug formulations in the context of the industry’s increasing interest in biologic drugs.
HOW MODEL BASED DEFINITION REVOLUTIONISES THE PRODUCTION OF MEDICAL DEVICES
INDUSTRIALISATION
Rob Doorakkers
IGS GeboJagema
HOW MODEL BASED DEFINITION REVOLUTIONISES THE PRODUCTION OF MEDICAL DEVICES
Rob Doorakkers looks at the advantages of the IGS GeboJagema’s Model Based Definition process and its ability to improve the quality of medical device production.
COMPUTATIONAL MODELLING OF INJECTION-RELATED TISSUE RESPONSES IN DRUG DELIVERY
INJECTION
Asmita Khanolkar
SMC Ltd
COMPUTATIONAL MODELLING OF INJECTION-RELATED TISSUE RESPONSES IN DRUG DELIVERY
Olivia Jefferies, Elizabeth Margerison and Asmita Khanolkar introduce Oval’s work on using ultrasound scanning and finite element analysis to construct a model of how tissue compresses under use of an autoinjector across patient demographics, and how this may provide insights into improved autoinjector design for more accurate injection depths, improving patient outcomes.
DRUG DELIVERY DEVICE TRENDS FOR 2022
EXPERT VIEW
Tom Oakley
DRUG DELIVERY DEVICE TRENDS FOR 2022
Tom Oakley looks at some of the current trends in the drug delivery industry and projects some of the key factors that will influence drug delivery decision making in 2022.
SO FAR SO GOOD: MAINTAINING THE MOMENTUM OF PROGRESS FOR SUSTAINABLE POLICIES
SUSTAINABILITY
Michael Earl
Owen Mumford
SO FAR SO GOOD: MAINTAINING THE MOMENTUM OF PROGRESS FOR SUSTAINABLE POLICIES
Michael Earl discusses the highlights of a review undertaken by Owen Mumford into how the pharmaceutical industry is faring on environmental, social and governance standards, noting that while the industry is performing above average overall, there remain some key areas for improvement.
VOICE-ACTIVATED USER INTERFACES IN DRUG DELIVERY DEVICES CAN ENHANCE COMPLIANCE AND OUTCOMES
EXPERT VIEW
Salvatore Forte
VOICE-ACTIVATED USER INTERFACES IN DRUG DELIVERY DEVICES CAN ENHANCE COMPLIANCE AND OUTCOMES
Salvatore Forte looks at the evolution of voice-activated interfaces in medical devices, particularly autoinjectors, and the advantages for patient compliance and quality of care.
MDR COMPLIANCE: PLANNING FOR POST-MARKET CLINICAL FOLLOW-UP
EXPERT VIEW
Dr Celeste Maksim
MDR COMPLIANCE: PLANNING FOR POST-MARKET CLINICAL FOLLOW-UP
Celeste Maksim discusses best practices for drug delivery device manufacturers when conducting post-market clinical follow-up activities, as mandated by the EU Medical Device Regulation.
TAKING INTEGRATED NEEDLE SAFETY SYSTEMS FOR PREFILLED SYRINGES TO THE NEXT LEVEL
PREFILLED SYRINGES
Michelle Deutsch
SCHOTT Pharma
TAKING INTEGRATED NEEDLE SAFETY SYSTEMS FOR PREFILLED SYRINGES TO THE NEXT LEVEL
Michelle Deutsch and John Merhige discuss the needle safety requirements of prefilled syringes and consider how SCHOTT TOPPAC® and syriQ® PFS with Credence Companion® technology combine to meet these challenges, while ensuring the device meets sustainability demands.
NEW BD SCF™ PREMIUMCOAT<sup>®</sup> 1MLL PLUNGER STOPPER: GLIDING TOWARDS DE-RISKED COMBINATION PRODUCT DEVELOPMENT
PREFILLED SYRINGES
Victoria Meyer
BD (Becton Dickinson & Company)
NEW BD SCF™ PREMIUMCOAT® 1MLL PLUNGER STOPPER: GLIDING TOWARDS DE-RISKED COMBINATION PRODUCT DEVELOPMENT
Victoria Meyer introduces the BD SCF™ PremiumCoat® 1mlL Plunger Stopper and explains how the product’s role is critical in determining combination products’ exposure to extractables and leachables.
FROM VIAL TO PREFILLED SYRINGE: MIGRATING A DRUG PRODUCT PRESENTATION
PREFILLED SYRINGES
Dr Martin Gonzalez
Pfizer CentreOne
FROM VIAL TO PREFILLED SYRINGE: MIGRATING A DRUG PRODUCT PRESENTATION
Martin Gonzalez discusses some of the most relevant engineering activities that are necessary to transfer a product successfully from a vial into a prefilled syringe presentation.
PHOTO-STABILITY TESTS OF EPINEPHRINE
PREFILLED SYRINGES
Yoshiko Sakuma
Mitsubishi Gas Chemical
PHOTO-STABILITY TESTS OF EPINEPHRINE
Yoshiko Sakuma and Tomohiro Suzuki provide an overview of OXYCAPT multilayer vial and syringe, with a particular emphasis on the advantages of OXYCAPT as a container for adrenaline, as demonstrated by recent studies conducted by MGC.
HOW MINIATURISED LIQUID FLOW SENSORS ARE REVOLUTIONISING SUBCUTANEOUS DRUG DELIVERY
CONNECTIVITY
Dr Andreas Alt
Sensirion
HOW MINIATURISED LIQUID FLOW SENSORS ARE REVOLUTIONISING SUBCUTANEOUS DRUG DELIVERY
Andreas Alt and Susanne Pianezzi describe the drivers accelerating industry trends towards both wearable subcutaneous injection devices and connecting such devices to monitor patient dosing, providing a number of benefits.
MATERIAL SELECTION FOR NEXT-GENERATION CONNECTED MEDICAL ELECTRONICS
CONNECTIVITY
Miriam Kingsley
Victrex
MATERIAL SELECTION FOR NEXT-GENERATION CONNECTED MEDICAL ELECTRONICS
Miriam Kingsley, Marcus Jarman-Smith and Thomas Billings highlight the growing array of applications for high-performance polymers in electronic and connected medical devices and how proper material selection is crucial, providing a guide to successful material selection, going on to showcase its APTIV™ PEEK polymer film, which is well suited to meet the specific demands of next-generation connected medical devices.
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