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PULMONARY

BENEFITS OF INNOVATIVE COMPRESSED GAS-POWERED INTRANASAL DRUG DELIVERY DEVICES
PULMONARY
Albie Lavin
Picocyl
BENEFITS OF INNOVATIVE COMPRESSED GAS-POWERED INTRANASAL DRUG DELIVERY DEVICES
Albie Lavin discusses the exciting potential of propellant-driven systems for intranasal delivery, and how Picocyl’s Pico-Cylinders provide the ideal mechanism to take advantage of this potential.
PERFECT TIMING FOR THE AUTOMATION OF OINDP TESTING
PULMONARY
Adam Smith
Copley Scientific
PERFECT TIMING FOR THE AUTOMATION OF OINDP TESTING
Adam Smith and Clair Brooks take a look at the benefits of automation, focusing on the actuation of metered dose inhalers and multidose nasal sprays/aerosols.
SPRAYTEC LASER DIFFRACTION: ROBUST, REPRODUCIBLE DROPLET SIZE DATA
PULMONARY
Dr Anne Virden
Malvern Panalytical
SPRAYTEC LASER DIFFRACTION: ROBUST, REPRODUCIBLE DROPLET SIZE DATA
Anne Virden discusses the benefits and applications of Malvern Panalytical's Spraytec laser diffraction system for the measurement of spray particles and droplets.
INTERVIEW: RDD EUROPE 2023 REVIEW & RDD 2024 PREVIEW
CONFERENCE SHOWCASE
RDD
INTERVIEW: RDD EUROPE 2023 REVIEW & RDD 2024 PREVIEW
Respiratory Drug Delivery talks with ONdrugDelivery, reviewing highlights of the successful RDD Europe 2023 event, which took place in Antibes, France last May, then describing what’s ahead for RDD 2024, which will take place in Tuscon, AZ, US, next May, including some of the key upcoming deadlines for participants.
EXPLORING THE PERFORMANCE OF LOW-GWP PROPELLANTS
SUSTAINABILITY
Grant Thurston
Proveris Scientific
EXPLORING THE PERFORMANCE OF LOW-GWP PROPELLANTS
Grant Thurston and Lynn Jordan discusses the performance of pressurised metered dose inhaler propellants with a low global warming potential.
CUSTOMISABLE MESH NEBULISER PLATFORMS: VALUE IN COMBINATION PRODUCT DEVELOPMENT
PULMONARY
Edgar Hernan Cuevas Brun
HCmed Innovations
CUSTOMISABLE MESH NEBULISER PLATFORMS: VALUE IN COMBINATION PRODUCT DEVELOPMENT
Edgar Hernan Cuevas Brun and Yuan-Ming Hsu look at the advantages of customisable nebuliser platforms for new combination products.
DEVELOPING AN INHALABLE FORMULATION OF THE FIRST GENERATIVE AI DRUG
PHARMA INSIGHT
Brita Belli
Insilico Medicine
DEVELOPING AN INHALABLE FORMULATION OF THE FIRST GENERATIVE AI DRUG
Brita Belli introduces Insilico Medecine’s inhalable formulation of its AI-designed therapy for the treatment of idiopathic pulmonary fibrosis, its progression through clinical trials and the company’s approach to generative AI in the pharmaceutical space more broadly.
THE IMPORTANCE OF THE BREATHING MANOEUVRE IN NEBULISED THERAPIES
EXPERT VIEW
Dr Carolina Dantas
THE IMPORTANCE OF THE BREATHING MANOEUVRE IN NEBULISED THERAPIES
Carolina Dantas and Ulf Krueger highlight the importance of the breathing manoeuvre in nebulised therapies – and describe a small study designed to test the effectiveness of patient feedback technology when it comes to guiding the inhalation manoeuvre. 
DRIVING SUSTAINABLE DRUG DELIVERY DEVICES WITH CONTINUOUS IMPROVEMENT PROCESSES
SUSTAINABILITY
Marc Severin
H&T Presspart
DRIVING SUSTAINABLE DRUG DELIVERY DEVICES WITH CONTINUOUS IMPROVEMENT PROCESSES
Marc Severin discusses the H&T Excellence programme and how it has been expanded to include methods and training to help H&T Presspart identify environmental impact at a product group level and take co-ordinated action to reduce carbon emissions across the organisation.
“A CHILD IS NOT A SMALL ADULT”: CHALLENGES AND SOLUTIONS IN DEVELOPING DRUG DELIVERY DEVICES FOR CHILDREN
EXPERT VIEW
Tom Oakley
“A CHILD IS NOT A SMALL ADULT”: CHALLENGES AND SOLUTIONS IN DEVELOPING DRUG DELIVERY DEVICES FOR CHILDREN
Tom Oakley and Heather Jameson consider the main differences in developing therapies and drug delivery devices for children and babies when compared with adults.
THE POTENTIAL OF CONNECTIVITY AND MONITORING IN MESH NEBULISERS
EXPERT VIEW
Dr Carolina Dantas
THE POTENTIAL OF CONNECTIVITY AND MONITORING IN MESH NEBULISERS
Carolina Dantas and Ulf Krueger review the current connectivity and remote monitoring capabilities in mesh nebulisers – and their potential to impact patients’ healthcare journeys and the clinical development of inhaled therapies.
NAVIGATING pMDI REFORMULATION 2.0
SUSTAINABILITY
Chris Baron
Aptar Pharma
NAVIGATING pMDI REFORMULATION 2.0
Chris Baron and William Ganley examine possible responses to the environmental impact of pressurised metered dose inhalers use and consider alternative inhaler types, with a focus on the strategies and support that can accelerate the development of the next generation of pMDIs.
THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES
PULMONARY
Dr Marie-Christine Klein
URSATEC
THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES
Marie-Christine Klein, Andreas Bilstein and Caroline Hoffmann discuss the underlying techniques involved in the use of metered pump-based soft mist devices and their application diversity.
NOVEL INDUSTRIAL-SCALE ELECTROSTATIC CHARGE ELIMINATION METHOD FOR INHALATION PRODUCTS
PULMONARY
Dr Orest Lastow
Iconovo
NOVEL INDUSTRIAL-SCALE ELECTROSTATIC CHARGE ELIMINATION METHOD FOR INHALATION PRODUCTS
Orest Lastow describes a novel technique for removing the built-up charge from dry powder inhaler components, offering a potential solution to the issues caused by static charges in these devices, including decreased performance, altered powder properties and increased variability in delivered dose.
DEVELOPMENT APPROACH FOR A HIGH-PERFORMANCE CAPSULE-BASED DPI
PULMONARY
Dr Mirjam Kobler
H&T Presspart
DEVELOPMENT APPROACH FOR A HIGH-PERFORMANCE CAPSULE-BASED DPI
Mirjam Kobler, Ameet Sule and Sunita Sule look at the factors affecting the performance of dry powder inhalers and discuss the company’s development of high-performance prototypes.
ARE YOU STRUGGLING TO PUT DIFFICULT POWDERS INTO CAPSULES?
PULMONARY
Andy Cleall
3P Innovation
ARE YOU STRUGGLING TO PUT DIFFICULT POWDERS INTO CAPSULES?
Andy Cleall and Ben Smith discuss process optimisation and cutting-edge technology for powder filling, including how 3P’s R500 and R1000 robotic capsule fillers are pushing the boundaries of optimal filling and how its Fill2Weight technology enables increased filling accuracy and improved yields.
CAPSULE FILLING FOR DPIs – LINKING PROCESS SCALES THROUGH ADVANCED CHARACTERISATION AND QUALITY BY DESIGN
PULMONARY
Dr Rui Churro
Hovione
CAPSULE FILLING FOR DPIs – LINKING PROCESS SCALES THROUGH ADVANCED CHARACTERISATION AND QUALITY BY DESIGN
 Rui Churro, Carolina Lopes and João Pires discuss the value of rheological characterisation of powders to expedite and de-risk the scale-up of DPI capsule-filling processes.
ISOTHERMAL DRY PARTICLE COATING – BACK TO THE FUTURE?
PULMONARY
Dr Jasdip Koner
Aston Particle Technologies
ISOTHERMAL DRY PARTICLE COATING – BACK TO THE FUTURE?
Jasdip Koner, Abdul Ershad and David Wyatt introduce Aston Particle Technologies’ novel dry powder processing technology – isothermal dry particle coating (iDPC™) – explaining how it has the capacity to enhance and broaden the scope of what dry powder formulations can achieve in respiratory medicine.
DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION
EXPERT VIEW
Matt Jones
DCA
DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION
Matt Jones and Rob Veasey consider the process of matching the drug with the right delivery device and look at the importance of due diligence when “licensing in” technology.
CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS
EXPERT VIEW
Mark Parry
CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS
Mark Parry discusses the considerations that need to be made when switching from current pressurised metered dose inhaler propellants to new alternatives with lower global warming potential, including formulation, regulatory and analytical standpoints.
ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER
CONNECTIVITY
Edgar Hernan Cuevas Brun
HCmed Innovations
ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER
Edgar Hernan Cuevas Brun and Yuan-Ming Hsu consider patient adherence and the role HCmed Innovations’ AdheResp mesh nebuliser plays in monitoring adherence.
DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS
CONNECTIVITY
Dr Haykel Ben Jamaa
Sensirion
DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS
Haykel Ben Jamaa explores why modern society needs digital health and how it is organised and implemented, with a focus on sensing technologies empowering digital health technologies.
WHY ARE INHALATION DEVICES SO DIFFICULT TO DEVELOP?
PULMONARY
Dr Orest Lastow
Iconovo
WHY ARE INHALATION DEVICES SO DIFFICULT TO DEVELOP?
Orest Lastow discusses the challenges of developing inhalation products and how best to keep costs down and prevent project delays.
CREATING A PLATFORM FOR NEBULISATION OF A WIDE RANGE OF DRUG TYPES AND FORMULATIONS
EARLY INSIGHT
Dr Elijah Nazarzadeh
Nebu~Flow
CREATING A PLATFORM FOR NEBULISATION OF A WIDE RANGE OF DRUG TYPES AND FORMULATIONS
Elijah Nazarzadeh and John Pritchard introduce Nebu~Flow – a novel class of nebuliser technology that represents a major step in the ability to deliver drugs efficiently to the lungs. overcoming the limitations of current systems and unlocking the potential of the inhalation route, including for systemic delivery.
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