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INDUSTRIALISATION

FAST-TO-MARKET DEVELOPMENT OF A NOVEL NASAL SPRAY WITH SIMULTANEOUS ENGINEERING
NASAL
Matthias Müller
Contexo
FAST-TO-MARKET DEVELOPMENT OF A NOVEL NASAL SPRAY WITH SIMULTANEOUS ENGINEERING
Matthias Müller details how a close collaboration between Contexo and a pharmaceutical manufacturer led to the rapid development of a novel nasal spray product, taking the project from prototyping to market within 14 months, shaving 10 months off the anticipated launch date.
ADVANCING ELASTOMER SEAL SOLUTIONS FOR THE PRESSURISED METERED DOSE INHALER MARKET
INDUSTRIALISATION
Nathan Sowder
Parker O-Ring & Engineered Seals Division
ADVANCING ELASTOMER SEAL SOLUTIONS FOR THE PRESSURISED METERED DOSE INHALER MARKET
Nathan Sowder discusses Parker O-Ring & Engineered Seals Division’s role and history in providing advanced elastomer seals and components to the drug delivery industry, with a particular emphasis on pressurised metered dose inhalers.
FACILITY SPOTLIGHT: UK-BASED CAPABILITIES IN INHALED AND NASAL DRUG-DEVICE PRODUCT DEVELOPMENT
RESPIRATORY
Ross Errington
Bespak
FACILITY SPOTLIGHT: UK-BASED CAPABILITIES IN INHALED AND NASAL DRUG-DEVICE PRODUCT DEVELOPMENT
Ross Errington introduces Bespak’s Holmes Chapel (UK) site, which is equipped to support device development programmes from early-stage formulation to large-scale manufacture.
A BREATH OF FRESH AIR: PHARMA’S PUSH FOR SUSTAINABLE pMDIs
SUSTAINABILITY
Andy Burns
Kindeva
A BREATH OF FRESH AIR: PHARMA’S PUSH FOR SUSTAINABLE pMDIs
Andy Burns considers the driving factors for the transition to more sustainable propellants, as well as explaining the benefits and challenges of these next-generation propellants in terms of compatibility, performance, safety and global warming potential.
SCALING LOW-CARBON pMDI PRODUCTION WITHOUT DISRUPTING PATIENT ACCESS
SUSTAINABILITY
Simon Gardner
Bespak
SCALING LOW-CARBON pMDI PRODUCTION WITHOUT DISRUPTING PATIENT ACCESS
Simon Gardner looks at how the pharmaceutical industry is scaling up production of low-carbon pressurised metered dose inhalers to cut emissions without disrupting patient care. The article considers the challenges faced by the industry, as well as the role of CDMOs in creating sustainable, scalable solutions.
INFLUENCE OF MACHINE CONCEPTS ON OVERALL EQUIPMENT EFFECTIVENESS
INDUSTRIALISATION
Dr Carsten Köhler
BBS Automation
INFLUENCE OF MACHINE CONCEPTS ON OVERALL EQUIPMENT EFFECTIVENESS
Carsten Köhler provides an overview of the key metrics that contribute to overall equipment effectiveness for manufacturing drug delivery devices, detailing some of the options available when considering large-scale, high-volume manufacture.
NOLATO’S VIRTUAL FACTORY IN ACTION: ACCELERATING DRUG DELIVERY INNOVATION
INDUSTRIALISATION
Patrik Ingvarsson
Nolato Group
NOLATO’S VIRTUAL FACTORY IN ACTION: ACCELERATING DRUG DELIVERY INNOVATION
Patrik Ingvarsson discusses Nolato’s virtual factory methodology, wherein embedded technical experts help drug delivery device developers reduce risk, costs and time to market through intelligent application of simulations to facilitate smoother and more robust development cycles with fewer iterations required.
FROM CARTRIDGE TO COMMERCIALISATION – UNDERSTANDING THE FILL-FINISH PROCESS
PREFILLED SYRINGES
Chelsea Keeton
Grand River Aseptic Manufacturing
FROM CARTRIDGE TO COMMERCIALISATION – UNDERSTANDING THE FILL-FINISH PROCESS
Chelsea Keeton digs into the challenging yet often overlooked process of fill-finish, discussing the particular hurdles and considerations that come with filling drug products into primary containers, with an emphasis on cartridges and their role in an injectables landscape increasingly influenced by the needs of biologics.
HIGH-SPEED ASSEMBLY OF NEEDLE SHIELDS FOR PREFILLED SYRINGES
INDUSTRIALISATION
Matthias Müller
Contexo
HIGH-SPEED ASSEMBLY OF NEEDLE SHIELDS FOR PREFILLED SYRINGES
Matthias Müller discusses the factors that set exceptional manufacturing equipment apart from the rest and how Contexo's new machine for assembling needle shields with prefilled syringes meets all these expectations.
INSIDE A TRACK-AND-TRACE SYSTEM FOR MEDICAL MOULDS: A MODEL FOR HEALTHCARE MANUFACTURING
INDUSTRIALISATION
Twan Mertens
IGS GeboJagema
INSIDE A TRACK-AND-TRACE SYSTEM FOR MEDICAL MOULDS: A MODEL FOR HEALTHCARE MANUFACTURING
Twan Mertens and Floor Verhorst-Willems  explore how IGS GeboJagema provides comprehensive visibility into every aspect of its operations with a 100% control track-and-trace process, spanning from initial sales discussions through to final validation and beyond.
A HOME for Your Molecule – Lifecore Biomedical
VIDEO
Lifecore Injectables
A HOME for Your Molecule – Lifecore Biomedical
More than a parenteral CDMO, your discovery deserves a home. A home where the level of care is unmatched. Learn why Lifecore Biomedical is the right home for your molecule.
HIGH SPEED LASER ASSEMBLY – FLEXIBLE MACHINE CONCEPTS WITH FULL LASER INTEGRATION
INDUSTRIALISATION
Matthias Müller
Contexo
HIGH SPEED LASER ASSEMBLY – FLEXIBLE MACHINE CONCEPTS WITH FULL LASER INTEGRATION
Matthias Müller discusses the advantages of including laser technology in drug delivery device manufacturing, covering the various ways in which this technology can be applied and used to provide efficient, cost-effective and clean processes at high throughput rates.
INJECTING DRUGS DIRECTLY INTO THE BODY: HOW ON-BODY DELIVERY SYSTEMS ARE REVOLUTIONISING THERAPY
WEARABLES
Peter Schmidt
ZwickRoell
INJECTING DRUGS DIRECTLY INTO THE BODY: HOW ON-BODY DELIVERY SYSTEMS ARE REVOLUTIONISING THERAPY
Peter Schmidt discusses the advantages of on-body delivery systems and what makes them special, going on to consider the significant role that they are expected to play in the future of injection technology for the pharmaceutical and medical fields, as well as the role that comprehensive testing plays in bringing this technology to patients.
SELF-INJECTION DEVICE MANUFACTURING IN A DYNAMIC WORLD
INDUSTRIALISATION
Philipp Richard
Ypsomed
SELF-INJECTION DEVICE MANUFACTURING IN A DYNAMIC WORLD
Philipp Richard scrutinises the efficient production of self-injection devices in the pharma industry and describes Ypsomed’s own platforms for developing these devices, highlighting the need to be adaptable and resilient to the rapidly evolving world of drug development. He provides valuable insights into the ways in which the flexible manufacture of self-injection devices might be achieved.
Interview: SHL Advantec – SHL Medical’s New Manufacturing Equipment Sub-Group
INTERVIEW
Gilbert Fluetsch
SHL Advantec
Interview: SHL Advantec – SHL Medical’s New Manufacturing Equipment Sub-Group
Gilbert Fluetsch discusses the establishment of SHL Advantec and the foundation it has built as SHL Medical’s in-house equipment specialist. Mr Fluetsch also looks at the role of modular platforms in scaling production and how the company’s global network is designed to support the changing landscape of medical and pharma manufacturing.
FINDING COMMON GROUND: FACTORS FOR ESTABLISHING AND SAFEGUARDING SHELF LIFE IN COMBINATION PRODUCTS
INDUSTRIALISATION
Lauren Orme
West Pharmaceutical Services
FINDING COMMON GROUND: FACTORS FOR ESTABLISHING AND SAFEGUARDING SHELF LIFE IN COMBINATION PRODUCTS
Lauren Orme discusses the regulatory considerations that need to be taken into account when designing combination products. She reviews the essential testing and standards required for both drug and device when establishing their shelf life and storage in a combined product.
Interview From Pilot to Scale Manufacturing
INTERVIEW
Glenn Svedberg
Nolato Group
Interview From Pilot to Scale Manufacturing
In this second exclusive interview with ONdrugDelivery, Glenn Svedberg talks with Guy Furness about Nolato’s role as a strategic partner for design, development and industrialisation within the pharmaceutical sector. In an engaging conversation, Mr Svedberg covers a wide range of subjects about Notalo, including the company’s virtual factory, decentralised structure, approach to scaling up from single-cavity moulds to commercial production, regulatory expertise and global footprint, discussing how the company can use each of these elements to support its partners’ device development and industrialisation programmes.
SHORTENING AND DECARBONISING THE INHALATION SUPPLY CHAIN
INDUSTRIALISATION
Louise Righton
Bespak
SHORTENING AND DECARBONISING THE INHALATION SUPPLY CHAIN
Louise Righton examines the potential for reducing emissions across the pMDI supply chain, considering the localisation of suppliers to shorten supply chains as well as strong partnerships for developing novel, low-carbon alternatives to current high-emission pMDI manufacturing processes.
CDMOs AS STRATEGIC ENABLERS FOR DEVICE INDUSTRIALISATION
INDUSTRIALISATION
Adam Nightingale
Sanner Group
CDMOs AS STRATEGIC ENABLERS FOR DEVICE INDUSTRIALISATION
Adam Nightingale explores a multitude of approaches to achieving more efficient and sustainable production of medical devices when partnering with a CDMO, and demonstrates the ways in which these partnerships can offer reduced risk and comply with regulations when streamlining industrialisation.
Interview: Phillips Medisize Grows its Capabilities with Vectura
INTERVIEW
Brian Thompson
Phillips Medisize
Interview: Phillips Medisize Grows its Capabilities with Vectura
In this exclusive interview with ONdrugDelivery’s Guy Furness, Brian Thompson and Dave Thoreson discuss Phillips Medisize’s expanded capabilities as a result of its recent acquisition of Vectura, bringing extensive expertise and experience in the inhalation sector within the global CDMO. The discussion covers how Phillips Medisize organises its global operations, the opportunities that the acquisition of Vectura represents and where the company goes next.
MASTERING COMMERCIAL MANUFACTURING FOR STERILE INJECTABLES
EXPERT VIEW
Jennifer Gattari
MASTERING COMMERCIAL MANUFACTURING FOR STERILE INJECTABLES
Jennifer Gattari delves into what is required to succeed at the commercial phase of sterile injectable manufacturing, going on to explore the challenges that companies can expect and the critical strategies that can help ensure a smooth and scalable journey to market.
PRESSURE ON THE SUPPLY CHAIN: TARIFFS, REGULATIONS AND TRANSPARENCY
EXPERT VIEW
Jacob Tyson
PRESSURE ON THE SUPPLY CHAIN: TARIFFS, REGULATIONS AND TRANSPARENCY
Jacob Tyson and Jon Lawrence consider the changes in the regulatory landscape for medical device manufacturers; the critical role that suppliers, distributors and importers play in ensuring effective post-market surveillance; and the technologies that companies are adopting to support traceability solutions.
HARNESSING X-RAY AND AI FOR A NEW ERA OF QUALITY CONTROL
EXPERT VIEW
Dr Richard Parmee
HARNESSING X-RAY AND AI FOR A NEW ERA OF QUALITY CONTROL
Dr Richard Parmee discusses the multitudinous applications of X-ray inspection technology for high-speed pharmaceutical production lines, covering the value of introducing artificial intelligence and machine learning techniques to enhance detection and improve safety.
Introducing Instron<sup>®</sup> AVE3 Advanced Video Extensometer
VIDEO
Landon Goldfarb
Instron
Introducing Instron® AVE3 Advanced Video Extensometer
This video introduces Instron’s premier extensometer solution, the AVE3. It is unrivaled in versatility, offering precision strain measurement for tensile, compression, and bend testing.
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