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PULMONARY

ISOTHERMAL DRY PARTICLE COATING – BACK TO THE FUTURE?
PULMONARY
Dr Jasdip Koner
Aston Particle Technologies
ISOTHERMAL DRY PARTICLE COATING – BACK TO THE FUTURE?
Jasdip Koner, Abdul Ershad and David Wyatt introduce Aston Particle Technologies’ novel dry powder processing technology – isothermal dry particle coating (iDPC™) – explaining how it has the capacity to enhance and broaden the scope of what dry powder formulations can achieve in respiratory medicine.
DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION
EXPERT VIEW
Matt Jones
DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION
Matt Jones and Rob Veasey consider the process of matching the drug with the right delivery device and look at the importance of due diligence when “licensing in” technology.
CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS
EXPERT VIEW
Mark Parry
CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS
Mark Parry discusses the considerations that need to be made when switching from current pressurised metered dose inhaler propellants to new alternatives with lower global warming potential, including formulation, regulatory and analytical standpoints.
ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER
CONNECTIVITY
Edgar Hernan Cuevas Brun
HCmed Innovations
ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER
Edgar Hernan Cuevas Brun and Yuan-Ming Hsu consider patient adherence and the role HCmed Innovations’ AdheResp mesh nebuliser plays in monitoring adherence.
DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS
CONNECTIVITY
Dr Haykel Ben Jamaa
Sensirion
DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS
Haykel Ben Jamaa explores why modern society needs digital health and how it is organised and implemented, with a focus on sensing technologies empowering digital health technologies.
WHY ARE INHALATION DEVICES SO DIFFICULT TO DEVELOP?
PULMONARY
Dr Orest Lastow
Iconovo
WHY ARE INHALATION DEVICES SO DIFFICULT TO DEVELOP?
Orest Lastow discusses the challenges of developing inhalation products and how best to keep costs down and prevent project delays.
CREATING A PLATFORM FOR NEBULISATION OF A WIDE RANGE OF DRUG TYPES AND FORMULATIONS
EARLY INSIGHT
Dr Elijah Nazarzadeh
Nebu~Flow
CREATING A PLATFORM FOR NEBULISATION OF A WIDE RANGE OF DRUG TYPES AND FORMULATIONS
Elijah Nazarzadeh and John Pritchard introduce Nebu~Flow – a novel class of nebuliser technology that represents a major step in the ability to deliver drugs efficiently to the lungs. overcoming the limitations of current systems and unlocking the potential of the inhalation route, including for systemic delivery.
A ROADMAP FOR DRUG-NEBULISER COMBINATION PRODUCT DEVELOPMENT
PULMONARY
Edgar Hernan Cuevas Brun
HCmed Innovations
A ROADMAP FOR DRUG-NEBULISER COMBINATION PRODUCT DEVELOPMENT
Edgar Hernan Cuevas Brun and Yuan-Ming Hsu lay out HCmed Innovations’ roadmap for the development of drug-nebuliser combination products.
AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST
SKIN
Dr Claire Authesserre
Eveon
AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST
Claire Authesserre and Florian Corne discuss the current challenges faced by the topical spray-based delivery of therapeutics and how EVEON’s Ad-Mist™ spray nozzle overcomes these challenges to harness the potential of this delivery route.
GETTING A GRIP ON FRICTION – A CRUCIAL CONSIDERATION FOR INHALER DESIGN
PULMONARY
Bryan Deacon
Celanese
GETTING A GRIP ON FRICTION – A CRUCIAL CONSIDERATION FOR INHALER DESIGN
Bryan Deacon discusses the importance of considering friction when developing a new inhaler design, providing an overview of some of the basic considerations friction raises, as well as highlighting how optimising friction early with the aid of a materials expert can reduce risk, lower cost and lead to a better product overall.
EXPLORING NEW IN VITRO TESTS TO DEMONSTRATE BIOEQUIVALENCE IN INHALATION PRODUCTS
PULMONARY
Lynn Jordan
Proveris Scientific
EXPLORING NEW IN VITRO TESTS TO DEMONSTRATE BIOEQUIVALENCE IN INHALATION PRODUCTS
Proveris Scientific looks at recent advances in in vitro testing in inhalation products to demonstrate bioequivalence and discusses the company’s INVIDA platform that replicates human usage of the device.
EXPANDING THE DESIGN OF CHARACTERISATION STUDIES FOR ACCURATE HANDLING-ERROR ASSESSMENT
EXPERT VIEW
Dr Yannick Baschung
EXPANDING THE DESIGN OF CHARACTERISATION STUDIES FOR ACCURATE HANDLING-ERROR ASSESSMENT
Yannick Baschung discusses the importance of a comprehensive and accurate assessment of patient handling errors when it comes to inhaled product development.
THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION
EXPERT VIEW
James Silk
THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION
James Silk discusses the importance of accounting for uncertainty when characterising the extractables profile of a medication, with particular reference to the ISO 10993 standard.
POWDER CHARACTERISATION FOR DPI PERFORMANCE IN CAPSULE-BASED INHALERS
PULMONARY
Dr Salvatore Pillitteri
Granutools
POWDER CHARACTERISATION FOR DPI PERFORMANCE IN CAPSULE-BASED INHALERS
Salvatore Pillitteri, Aurélien Neveu and Sarah Zellnitz-Neugebauer discuss the analysis of three powder blends of salbutamol sulphate with distinct lactose grades, using tapped density and rotating drum methods.
DELIVERING BIOLOGICS WITH SOFT MIST INHALERS – A MARKET POISED TO EXPAND
PULMONARY
Dr Philippe Rogueda
Merxin Ltd
DELIVERING BIOLOGICS WITH SOFT MIST INHALERS – A MARKET POISED TO EXPAND
Philippe Rogueda discusses the inhalable biologics market, how the introduction of soft mist inhalers represents a significant opportunity for new and old therapeutics alike, and how the market is poised for a major expansion in therapeutic application, size and value.
ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE
INDUSTRIALISATION
Drew Jelgerhuis
Scherdel Medtec North America
ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE
Drew Jelgerhuis looks at how a design-for-excellence (DFX) systematic approach can help manufacturers achieve their objectives.
HIGH-PRECISION INJECTION MOULDS FOR INHALERS: CHALLENGES AND SOLUTIONS
INDUSTRIALISATION
Rob Doorakkers
IGS GeboJagema
HIGH-PRECISION INJECTION MOULDS FOR INHALERS: CHALLENGES AND SOLUTIONS
Rob Doorakkers and Erwin van Huijksloot discuss the challenges and solutions of engineering and manufacturing high-precision injection moulds for inhalers.
CLIPhaler – INHALATION DEVICE DESIGN REDUCED TO THE MAXIMUM
EARLY INSIGHT
Dr Klaus-Dieter Beller
CLIPhaler – INHALATION DEVICE DESIGN REDUCED TO THE MAXIMUM
Klaus-Dieter Beller discusses the advantages of the inhalation route of administration, how his principle of design simplicity has informed the design of novel inhalation devices and introduces CLIPhaler, his latest and simplest device.
THE INNOVATIONS TACKLING CHALLENGES & MAXIMISING OPPORTUNITIES IN INHALATION
EXPERT VIEW
Marco Franza
THE INNOVATIONS TACKLING CHALLENGES & MAXIMISING OPPORTUNITIES IN INHALATION
Marco Franza and Nadine Khoury look at how the latest digital technologies, manufacturing techniques and packaging materials are combining to take the manufacture of inhalers to a new level.
TAKING THE STING OUT OF VACCINES
EXPERT VIEW
Dr Heather Jameson
TAKING THE STING OUT OF VACCINES
Heather Jameson, Juliette Ngan and Omar Shah discuss the potential advantages and challenges of intranasal and inhaled vaccines in the context of global respiratory pandemics.
SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS
EXPERT VIEW
Dr Paul Kippax
SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS
Paul Kippax discusses the analytical techniques used for in vitro characterisation of nasal sprays, and how their use can accelerate and de-risk both innovator and generic nasal drug development.
MAKING SUSTAINABILITY BY DESIGN THE LINTEL OF SUSTAINABLE INHALER DEVELOPMENT
SUSTAINABILITY
Phil Seeney
PA Consulting
MAKING SUSTAINABILITY BY DESIGN THE LINTEL OF SUSTAINABLE INHALER DEVELOPMENT
Phil Seeney, Philip Winkworth and Craig Nelson provide an insight into sustainability developments in the pharmaceutical industry, with a focus on inhalables.
CONSIDERING THE SUSTAINABILITY IMPACT OF CONNECTED INHALERS IN THE TREATMENT OF ASTHMA
SUSTAINABILITY
Dr Iain Simpson
Phillips-Medisize
CONSIDERING THE SUSTAINABILITY IMPACT OF CONNECTED INHALERS IN THE TREATMENT OF ASTHMA
Iain Simpson and Vinith Bhandari consider the sustainability impact of device connectivity specific to asthma inhalers through the reduction of greenhouse gas emissions.
SUSTAINABILITY MEASURES ARE THE KEY TO MEETING ESG COMMITMENTS
SUSTAINABILITY
Matthias Birkhoff
Aptar Pharma
SUSTAINABILITY MEASURES ARE THE KEY TO MEETING ESG COMMITMENTS
Matthias Birkhoff and Christophe Marie discuss the advances Aptar Pharma has made in delivering on its sustainability objectives.
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