ONdrugDelivery - ONdrugDelivery - drug delivery industry specialised b2b information

ENABLING LARGE-DOSE, HIGH-VOLUME SUBCUTANEOUS AUTOINJECTION WITH CARTRIDGE-BASED TECHNOLOGY

Michael McGowan examines the emerging interest in autoinjectors that are capable of delivering higher injection volumes into the subcutaneous space and considers the potential benefits of SHL Medical’s cartridge-based 3 and 5 mL Maggie^® autoinjectors

PATIENT-CENTRIC DESIGN CAN BE A FASTER PATH TO MARKET

Brent Buchine considers a faster path to market for automated and easy-to-use reconstitution devices through simplification of the delivery systems.

AN INTUITIVE ALL-IN-ONE AUTOINJECTOR: EMBEDDED MIXING & INJECTION TECHNOLOGIES SIMPLIFY DAY-TO-DAY LIFE

Benjamin Morel and Gladys Corrons-Bouis, discuss the challenges faced by the injectable drug delivery industry and present EVEON’s solution – the INTUITY^® Ject MX platform.

NEXT-GENERATION AUTOINJECTOR PLATFORM FOR HIGH-DOSE DRUGS

Richard Whelton

Congruence Medical Solutions

NEXT-GENERATION AUTOINJECTOR PLATFORM FOR HIGH-DOSE DRUGS

Richard Whelton introduces the new Congruence Autoinjector, a next-generation disposable autoinjector platform, which leverages a compressed-gas power source and has significant advantages over currently available legacy devices, including the ability to deliver higher viscosity and larger volume drugs, easier customisation and enhanced usability that addresses well-known user errors.

OPPORTUNITIES FOR INNOVATION WITH BIOSIMILARS

PREFILLED SYRINGES

Dr Iain Simpson

Phillips-Medisize

OPPORTUNITIES FOR INNOVATION WITH BIOSIMILARS

Iain Simpson and George Spooner investigate the use of drug delivery systems that support self-administration of biologic drugs, and specifically biosimilars, for the treatment of chronic diseases. This article is based on research conducted by both authors as part of the MPhil in Therapeutic Sciences at the University of Cambridge (UK) and supported by Phillips-Medisize.

Pro-Tects – A NOVEL SOLUTION TO THE CHALLENGE OF BIOLOGIC INSTABILITY

Glycome BioPharma

Pro-Tects – A NOVEL SOLUTION TO THE CHALLENGE OF BIOLOGIC INSTABILITY

Shane Smith, Eoin Scanlan and Paula Colavita discusses the difficulty inherent in developing parenteral biologic products due to the challenge of creating a stable formulation in the face of surface-mediated protein aggregation and introduces Pro-Tects – Glycome’s patented surface-treatment technology platform that offers a solution to this critical issue without introducing further development challenges.

ENABLING DRUG DEVELOPMENT THROUGH DRUG DELIVERY MANUFACTURING

Dr Andrei Yosef

ENABLING DRUG DEVELOPMENT THROUGH DRUG DELIVERY MANUFACTURING

Andrei Yosef looks at the role of manufacturing in the development of drug delivery devices and highlights the benefits of the company’s Sorrel device, which enables pharma companies to experiment during clinical trials to ensure that drugs produced are safe and cost-effective.

PRODUCT SHOWCASE: New Requirements for Injection Devices Make Advanced Testing Solutions Necessary

INDUSTRIALISATION

PRODUCT SHOWCASE: New Requirements for Injection Devices Make Advanced Testing Solutions Necessary

ZwickRoell showcases its advanced testing solutions for injection devices including pens, autoinjectors and on-body delivery systems.

OXYCAPT: SUPERIOR PRIMARY CONTAINERS FOR BIOLOGICS AND GENE AND CELL THERAPIES

PREFILLED SYRINGES

Dr Yasuaki Yoshimura

Mitsubishi Gas Chemical

OXYCAPT: SUPERIOR PRIMARY CONTAINERS FOR BIOLOGICS AND GENE AND CELL THERAPIES

Yasuaki Yoshimura and Tomohiro Suzuki review the advantages that OXYCAPT, the company’s multilayer material for vials, offers to biologics and gene and cell therapies, and discuss the results of recent tests into low temperature storage and dimethyl sulfoxide resistance.

Interview: Kymanox Executive Advisors Mathias Romacker, Fran DeGrazio & Paul Jansen

Interview: Kymanox Executive Advisors Mathias Romacker, Fran DeGrazio & Paul Jansen

Mathias Romacker, Fran DeGrazio and Paul Jansen sit down with Guy Furness, to discuss what it is that has driven Kymanox’s rapid rise in the drug delivery space and what makes the consulting company’s model so successful, as well as to share their expertise on a variety of topics in an illuminating discussion, including connectivity, how large and small drug developers engage with consultancies, 5 mL autoinjectors and the interface between drug primary packaging and delivery devices.

SILICONE-OIL-FREE PREFILLED SYRINGE SYSTEMS – GUIDANCE FOR SELECTING THE APPROPRIATE PACKAGING MATERIALS AND FOR SILICONISATION

PREFILLED SYRINGES

SILICONE-OIL-FREE PREFILLED SYRINGE SYSTEMS – GUIDANCE FOR SELECTING THE APPROPRIATE PACKAGING MATERIALS AND FOR SILICONISATION

Bernd Zeiss addresses the influence of silicone oil on syringe systems and highlights the advantages and possibilities of novel silicone-oil-free prefillable syringes, both for glass and for plastic syringes.

Interview: Gabriel Zenker, Aptar Pharma

Interview: Gabriel Zenker, Aptar Pharma

Gabriel Zenker talks with ONdrugDelivery about Aptar Pharma’s ambitions for the parenterals sector. Mr Zenker explains how Aptar, already a major player in the pulmonary, nasal, ophthalmic and dermal markets, is undertaking a major expansion of its facilities, boosting the company’s capacity, capabilities and technologies, to provide its extensive service and product offering to the exciting injectables space.

ACCELERATING NOVEL THERAPIES TO THE CLINIC – CUSTOM SOLUTIONS

PREFILLED SYRINGES

Asmita Khanolkar

ACCELERATING NOVEL THERAPIES TO THE CLINIC – CUSTOM SOLUTIONS

Asmita Khanolkar discusses the key offerings necessary to accelerate “speed to clinic” for custom manufacturing solutions.

THE OPERATIONS PERSPECTIVE: BEST PRACTICES FROM 70 YEARS IN INJECTION DEVICE MANUFACTURING

THE OPERATIONS PERSPECTIVE: BEST PRACTICES FROM 70 YEARS IN INJECTION DEVICE MANUFACTURING

John Swift looks at how the company has evolved over 70 years, introduces its latest disposable autoinjector, Aidaptus, and considers how it plans to actively reduce risk in its supply chain.

LOW-COMPLEXITY, EASY-TO-USE WEARABLE INJECTION PLATFORM

LOW-COMPLEXITY, EASY-TO-USE WEARABLE INJECTION PLATFORM

Jesper Roested discusses the increasing prevalence of biologics formulated for large-volume injections in drug development and how wearable devices, including Subcuject’s offering, may be a better solution for delivering these drugs than scaled-up conventional autoinjectors.

REDUCE PHARMA DEVELOPMENT TIME: LARGE-VOLUME SUBCUTANEOUS DELIVERY WITH THE ENFUSE<sup>®</sup>

Enable Injections

REDUCE PHARMA DEVELOPMENT TIME: LARGE-VOLUME SUBCUTANEOUS DELIVERY WITH THE ENFUSE^®

Mehul Desai discusses how Enable Injections' enFuse^® delivery system provides a flexible alternative for subcutaneous administration of high-volume therapeutics.

ANTICIPATING & MITIGATING CHALLENGES IN THE COMMERCIALISATION OF PREFILLED SYRINGES & INJECTION DEVICES – A TECHNICAL DRUG PRODUCT PERSPECTIVE

PREFILLED SYRINGES

Dr Andrea Allmendinger

ANTICIPATING & MITIGATING CHALLENGES IN THE COMMERCIALISATION OF PREFILLED SYRINGES & INJECTION DEVICES – A TECHNICAL DRUG PRODUCT PERSPECTIVE

Andrea Allmendinger and Hanns-Christian Mahler both at ten23 health, provide an insight into the challenges of integrated development of drug product and device design and fill-finish manufacturing operations.

A TALE OF TWO SPRINGS

PREFILLED SYRINGES

Sebastian Block

Scherdel Medtec North America

A TALE OF TWO SPRINGS

Sebastian Block and Drew Jelgerhuis introduce two types of springs and highlight their important role in drug delivery devices.

ENGINEERING ADVANCES IN NEEDLE GEOMETRY TO ACCOMMODATE VISCOUS BIOLOGICS

Stevanato Group

ENGINEERING ADVANCES IN NEEDLE GEOMETRY TO ACCOMMODATE VISCOUS BIOLOGICS

Silvia Gallina discusses the challenges faced in administering highly viscous biologics to patients via subcutaneous injection, and how Stevanato Group’s new special thin-wall needles are able to tackle them.

BEING PREPARED FOR PHARMA INNOVATION IS KEY IN 2023

Victoria Morgan

West Pharmaceutical Services

BEING PREPARED FOR PHARMA INNOVATION IS KEY IN 2023

Victoria Morgan and Ana Marques Kuschel discuss three recent innovations that West Pharmaceutical Services has introduced to enable its partners to respond to specific market-driven challenges, from pandemic-driven pressures on fill-finish productivity to the underlying shift towards biologics and the accelerated growth of home-based treatment.

EXTRACTABLES/LEACHABLES TESTING CONSIDERATIONS FOR SINGLE-USE SYSTEMS

EXTRACTABLES/LEACHABLES TESTING CONSIDERATIONS FOR SINGLE-USE SYSTEMS

Sandi Schaible discusses testing considerations for extractables and leachables along with the regulatory environment for single-use systems.

Pharmapack Expert Panel on Patient-Centric Digital Health: Interview with Ben Cox, Team Consulting

Team Consulting

Pharmapack Expert Panel on Patient-Centric Digital Health: Interview with Ben Cox, Team Consulting

With Pharmapack returning to its traditional February timing in 2023, Team Consulting will be chairing a Day 1 expert panel discussion on patient-centric digital health solutions. Interviewed here, Ben Cox provides insight into trends the panel will discuss, lays out the current status of the industry with respect to digital health and considers what to look forward to at Pharmapack this year.

DESIGNING EFFECTIVE AND ENGAGING DIGITAL SOLUTIONS TO DRIVE ADHERENCE

Florian Krummenacher

DESIGNING EFFECTIVE AND ENGAGING DIGITAL SOLUTIONS TO DRIVE ADHERENCE

Florian Krummenacher and Philippe Müller discuss the effectiveness of combining connected injection devices with digital solutions to drive therapy outcomes.

Connected Drug Delivery – Is the Near-Term Opportunity in Clinical Development? – an Interview with Oliver Eden

Jabil Healthcare

Connected Drug Delivery – Is the Near-Term Opportunity in Clinical Development? – an Interview with Oliver Eden

Oliver Eden of Jabil Healthcare looks at the factors influencing the return on investment metrics in clinical development and introduces Jabil’s autoinjector platform Qfinity™ and its connected version, Qfinity+™.

ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER

Edgar Hernan Cuevas Brun

HCmed Innovations

ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER

Edgar Hernan Cuevas Brun and Yuan-Ming Hsu consider patient adherence and the role HCmed Innovations’ AdheResp mesh nebuliser plays in monitoring adherence.

DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS

Dr Haykel Ben Jamaa

DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS

Haykel Ben Jamaa explores why modern society needs digital health and how it is organised and implemented, with a focus on sensing technologies empowering digital health technologies.

COULD VIVERA BE THE NEXT MEDTECH UNICORN START-UP?

Amanda Whitcroft

Vivera Pharmaceuticals

COULD VIVERA BE THE NEXT MEDTECH UNICORN START-UP?

Few technology companies reach unicorn status. US medtech company Vivera is hoping to be the next one, with its innovative approach to prescription drug delivery that aims to increase patient adherence and stop prescription drug abuse.

STEPS TO SUCCESS IN NOSE-TO-BRAIN DRUG DELIVERY

STEPS TO SUCCESS IN NOSE-TO-BRAIN DRUG DELIVERY

Reenal Gandhi and Gemma Budd consider the multiple hurdles associated with developing nasal drug delivery solutions, current understanding of the associated biology and the advantages of alternative device designs and state-of-the-art formulation practice.

CREATING A PLATFORM FOR NEBULISATION OF A WIDE RANGE OF DRUG TYPES AND FORMULATIONS

Dr Elijah Nazarzadeh

CREATING A PLATFORM FOR NEBULISATION OF A WIDE RANGE OF DRUG TYPES AND FORMULATIONS

Elijah Nazarzadeh and John Pritchard introduce Nebu~Flow – a novel class of nebuliser technology that represents a major step in the ability to deliver drugs efficiently to the lungs. overcoming the limitations of current systems and unlocking the potential of the inhalation route, including for systemic delivery.

A ROADMAP FOR DRUG-NEBULISER COMBINATION PRODUCT DEVELOPMENT

Edgar Hernan Cuevas Brun

HCmed Innovations

A ROADMAP FOR DRUG-NEBULISER COMBINATION PRODUCT DEVELOPMENT

Edgar Hernan Cuevas Brun and Yuan-Ming Hsu lay out HCmed Innovations’ roadmap for the development of drug-nebuliser combination products.

AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST

Dr Claire Authesserre

AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST

Claire Authesserre and Florian Corne discuss the current challenges faced by the topical spray-based delivery of therapeutics and how EVEON’s Ad-Mist™ spray nozzle overcomes these challenges to harness the potential of this delivery route.

GETTING A GRIP ON FRICTION – A CRUCIAL CONSIDERATION FOR INHALER DESIGN

GETTING A GRIP ON FRICTION – A CRUCIAL CONSIDERATION FOR INHALER DESIGN

Bryan Deacon discusses the importance of considering friction when developing a new inhaler design, providing an overview of some of the basic considerations friction raises, as well as highlighting how optimising friction early with the aid of a materials expert can reduce risk, lower cost and lead to a better product overall.

EXPLORING NEW IN VITRO TESTS TO DEMONSTRATE BIOEQUIVALENCE IN INHALATION PRODUCTS

Proveris Scientific

EXPLORING NEW IN VITRO TESTS TO DEMONSTRATE BIOEQUIVALENCE IN INHALATION PRODUCTS

Proveris Scientific looks at recent advances in in vitro testing in inhalation products to demonstrate bioequivalence and discusses the company’s INVIDA platform that replicates human usage of the device.

EXPANDING THE DESIGN OF CHARACTERISATION STUDIES FOR ACCURATE HANDLING-ERROR ASSESSMENT

Dr Yannick Baschung

EXPANDING THE DESIGN OF CHARACTERISATION STUDIES FOR ACCURATE HANDLING-ERROR ASSESSMENT

Yannick Baschung discusses the importance of a comprehensive and accurate assessment of patient handling errors when it comes to inhaled product development.

THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION

THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION

James Silk discusses the importance of accounting for uncertainty when characterising the extractables profile of a medication, with particular reference to the ISO 10993 standard.

POWDER CHARACTERISATION FOR DPI PERFORMANCE IN CAPSULE-BASED INHALERS

Dr Salvatore Pillitteri

POWDER CHARACTERISATION FOR DPI PERFORMANCE IN CAPSULE-BASED INHALERS

Salvatore Pillitteri, Aurélien Neveu and Sarah Zellnitz-Neugebauer discuss the analysis of three powder blends of salbutamol sulphate with distinct lactose grades, using tapped density and rotating drum methods.

DELIVERING BIOLOGICS WITH SOFT MIST INHALERS – A MARKET POISED TO EXPAND

Dr Philippe Rogueda

DELIVERING BIOLOGICS WITH SOFT MIST INHALERS – A MARKET POISED TO EXPAND

Philippe Rogueda discusses the inhalable biologics market, how the introduction of soft mist inhalers represents a significant opportunity for new and old therapeutics alike, and how the market is poised for a major expansion in therapeutic application, size and value.

HIGH-PRECISION INJECTION MOULDS FOR INHALERS: CHALLENGES AND SOLUTIONS

INDUSTRIALISATION

HIGH-PRECISION INJECTION MOULDS FOR INHALERS: CHALLENGES AND SOLUTIONS

Rob Doorakkers and Erwin van Huijksloot discuss the challenges and solutions of engineering and manufacturing high-precision injection moulds for inhalers.

CLIPhaler – INHALATION DEVICE DESIGN REDUCED TO THE MAXIMUM

Dr Klaus-Dieter Beller

CLIPhaler – INHALATION DEVICE DESIGN REDUCED TO THE MAXIMUM

Klaus-Dieter Beller discusses the advantages of the inhalation route of administration, how his principle of design simplicity has informed the design of novel inhalation devices and introduces CLIPhaler, his latest and simplest device.

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